Sentences with phrase «with upregulation»

Consistent with having a lower temperature tolerance, longfin smelt exhibited a pronounced cellular stress response, with an upregulation of heat shock proteins, after exposure to 20 °C that was not observed in delta smelt.

CBX2 overexpression in breast tumors was associated with the upregulation of genes involved in cell cycle progression and is associated with poorer 5 - year survival.

Inhibitory effects of antagonists of growth hormone releasing hormone on experimental prostate cancers are associated with upregulation of wildtype p53 and decrease in p21 and mutant p53 proteins.

Not exact matches

The roadmap outlines future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, the coordination of regenerative and ablative technologies, and methods of slowing metabolic activity while preserving cognitive function.

The immune activation from the CAR cells was also met with resistance mechanisms, including an upregulation of immunosuppressive pathways which may work against the patient and for the tumor, the researchers found.

The researchers from the study group were able to show that upregulation of the growth factor VEGF - B, which is related to VEGF - A, in the primary tumor in the bowel prior to treatment was associated with a poorer prognosis, whereas upregulation of VEGF - B in the liver metastases after treatment was associated with a better prognosis.

On November 10th, the SMA Foundation held a meeting with over 100 SMA researchers, clinicians, and patient advocacy group representatives to discuss the potential impact of SMN upregulation outside of the central nervous system (CNS).

Notably, they observed that MITF expression correlates with CDK2 upregulation in patients; thus, dinaciclib would warrant consideration for treatment of patients unresponsive to BRAF ‐ MEK and / or Hsp90 inhibitors and / or harboring MITF amplification / overexpression.

Glennie et al 134 have shown that T cells stimulated in co-cultures with MSC exhibit an extensive inhibition of cyclin D2 and upregulation of the cyclin dependent kinase inhibitor p27kip1.

The Horch lab previously correlated upregulation of sema2a — the gene that codes for a diffusible semaphorin protein in invertebrates — with this compensatory growth.

In accordance with in vitro data, upregulation of H3K4me3 was more significant in the combination treatment group than in the single - agent and the untreated group (Figure 4E).

It was also suggested that more manifestations outside of the nervous system may be observed as severe Type I patients survive longer with SMN upregulation in the CNS only.

Accordingly, p - ERK upregulation was observed not only in tumor samples of PTCL - NOS patients with KMT2D mutations, but also in those of xenografted T - lymphoma mice bearing KMT2D V5486M mutants, the latter being inhibited by combined treatment with chidamide and decitabine (Figure 5F, G).

Their gene expression analysis throughout the protocol matched that of a previously published profile for hESCs [24], which included the significant upregulation of mesodermal and chondrogenic markers (PDGFRB, SOX6, SOX9, ACAN, COL2A1 types A and B), with the more mature COL2A1 type B splice variant [42] being more highly expressed by the end of stage 3.

Since TNFα is such a potent inducer of apoptosis through TNFR1 death domain signaling, and amiodarone treatment results in the down regulation of TNFα with concomitant upregulation in TNFR2 signaling in NSC alone, it is possible that amiodarone selectively kills NSCs by lowering the threshold of TNFα required to trigger apoptosis in NSCs via upregulation of TNFR2 pathways in NSCs and not dopaminergic neurons.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

Although LPS causes CCR7 upregulation on splenic DCs and promotes their movement to the T zone (De Becker et al., 2000; De Trez et al., 2005; Seul et al., 2012) we found that LPS - mediated repositioning happened more slowly and with a more uniform distribution of DCs through the T zone than occurred following SRBC immunization.

In the absence of the natural upregulation and downregulation of the TSH, the feedback mechanism regulating thyroid hormone levels may become inefficient with disuse.

With IF, you get increased enzymatic activity of fat burning enzymes and upregulation of carbohydrate storage enzymes.

Because the further improvement in muscle glucose transport in the combined group was not associated with additional upregulation of GLUT - 4 protein or a further reduction in oxidative stress, the mechanism for this interaction must be due to additional, as yet unidentified, factors.