Compared to children whose mothers did not have epilepsy, the risk of autism was seven times higher in
those with valproate exposure.
In patients who have a «Met» variant of COMT, rising levels of proline appeared to do the exact opposite: these patients had more or worse negative symptoms, and the symptoms did not improve
with valproate.
Among those patients who were being treated
with valproate (approximately one - third of the schizophrenia patients), negative symptoms were more severe in those with the Met / Met gene than in those with the Val / Val gene.
The researchers also evaluated negative symptoms in 43 patients with bipolar disorder, about half of whom were treated
with valproate.
Not exact matches
The study helps determine the effects of CBD in combination
with common AEDs, including carbamazepine,
valproate, levetiracetam, clobazam and lacosamide.
«This information may help to determine which patients may be most likely to benefit from treatment
with mood stabilizers such as
valproate that are known to modulate proline levels.»
The authors conclude that
valproate may be effective for treating negative symptoms in psychiatric patients
with two copies of the «Val» variant of the COMT gene, which breaks down dopamine in the brain.
Of these 171 women, 42 had taken levetiracetam, 27 had taken topirimate and 47 had taken
valproate while pregnant — an additional control group of women
with similarly - aged children who had not taken any antiepileptic drug while pregnant was also included in the study.
In the roughly 40 percent of patients
with this genotype, higher levels of proline (a neuromodulator that is increased by
valproate), correlated
with fewer negative symptoms.
Valproate, one of the most commonly prescribed antiepileptic medications, has been associated in the past
with birth defects and developmental problems.
The study of 6,671 individuals found lower rates of self - harm and unintentional injuries among those patients taking lithium compared
with those prescribed
valproate, olanzapine or quetiapine.
A common mood - stabilizing drug,
valproate, is found to control manic - like behavior induced in mice
with an extra copy of a gene called SHANK3
Neural tube malformations are most common
with the use of
Valproate, a folic acid antagonist.
Study of the effect of
valproate on pulmonary cancer cells, in combination
with chemotherapy agents.
By Kate Stinchfield MONDAY, Dec. 1, 2008 (Health.com)-- Pregnant women who take the epilepsy drug
valproate may be more likely to have a child
with autism than those who don't take the seizure - controlling drug, according to a study published Monday in the journal Neurology.
Patients
with bipolar disorder were being treated
with mood stabilizing agents (i.e., lithium,
valproate, or lamotrigine)
with or without atypical antipsychotics.
Valproate reduces alcohol consumption in people
with comorbid alcohol dependency and bipolar disorder