Sentences with phrase «with wild type»

p - Values for pairwise comparison with wild type unless indicated otherwise.

«Recent data have described a correlation between the levels of activated Notch1 and poor prognosis in a cohort of NSCLC patients, but only in patients with wild type p53,» a group that they wrote represents about half of all NSCLC patients.

We observed that Erk phosphorylation was modestly enhanced in Cbl - b − / − CD8 + T cells when compared with wild type (WT) T cells but was greatly enhanced in DGKζ − / − and DKO CD8 + T cells when compared either with Cbl - b − / − or WT CD8 + T cells (Fig. 1A).

Like bsl1 - 1, spikelets appeared to form in place of bristles; however, by 18 DAS, bristles were differentiated in bsl1 - 2, but fewer compared with the wild type (Supplemental Figures 3C and 3H).

Deletion of DGKζ or Cbl - b comparably enhanced CD8 + T cell functional responses, such as proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type T cells.

Morphological analysis of spikelet - to - bristle ratios in bsl1 mutants compared with the wild type.

Our RNA - seq analyses showed that SvBd1 (Sevir.2 G437800), encoding the ortholog of a conserved AP2 - ERF TF, which specifies SM identity in maize and other grasses (Chuck et al., 2002), was expressed at substantially higher levels in the bsl1 - 1 mutant compared with the wild type, consistent with increased production of spikelets in place of bristles (Table 2).

As with most other observed phenotypes, spikelet - to - bristle ratio was intermediate in the bsl1 - 2 mutant compared with the wild type and bsl1 - 1 (Supplemental Figure 4).

For example, vemurafenib is more effective in melanoma containing BRAFV600E mutation, than melanoma cells with wild type BRAF protein.

All clones with the wild type Tyr302, including the Envs from the viral innoculum and two Envs from X4 - ZFN mice utilized CXCR4 approximately 1000-fold more efficiently than CCR5 and comparably to the X4 - tropic control TYBE (Figure 6C).

The Kansas Department of Agriculture reports that a horse in northeast Kansas has been confirmed positive with a wild type of non-neurotropic case of equine herpes virus, or EHV - 1.

Not exact matches

I have a soft spot in my heart for plucky li» l Natsume, and I think two of its SNES games would help to round out the lineup here and add in some two - player goodness: Wild Guns is a cooperative shooting - gallery type game with a Western aesthetic, and Pocky is an adorable top - down scrolling shooter starring a priestess and her tanuki pal.

One wild card option — that's still not a full Internet alternative (yet)-- is to use a different type of network that's being engineered with privacy in mind.

At least in part to deal with such points, Eigen more recently pointed out that each biological genome is not a single sequence of bases on DNA (a unique «point in sequence space») but rather a fairly large number of variant sequences that have quite similar — even indistinguishable — biological functions.11 b, 11 c Most of these functionally similar sequences differ from the «wild - type» sequence in only one or a few locations, but some have fairly large discrepancies.

Rather than being a point in sequence - space, each such quasi-species» may be regarded as a cloud of such points, with high density in the region of the wild - type but with significant, long extensions in several directions.

I am not thrilled with the idea of a «wild» Jesus either, though I do think He was not the docile, soft - spoken type of man we most often portray Him to be.

Wild type chili pepper with piercing pungency which comes down quite quickly.

An interesting, quite hot wild pepper with a piercing pungency type.

-LSB-...] And then there was Friday evening... this one was your typical Thanksgiving feast; with turkey and ham, mashed potatoes and gravy, stuffing, corn, carrots, two types of green bean casserole, pumpkin bread, a veggie tray, cranberry salad, pumpkin pie, apple pie, wild berry pie, the excess pie crust baked off with some cinnamon and sugar (a very rare indulgence), and I made an amazingly rich and delicious pecan pie without the crust (only because I was in a rush) from Predominantly Paleo.

I used wild nori here, but feel free to experiment with different types of seaweed - also, feel free to play with the amount of seaweed you use, I could certainly imagine using more in this particular salad.You can make certain components ahead of time - the dressing and tofu, and the rice.

And I usually make this with brown or wild rice, but any type of steamed rice will do, just as long as it's day - old or cold.

I've made this with both wild rice and brown rice, but you could easily use other types of whole grains - farro, millet and quinoa all work.

While I stuck with cremini mushrooms for today, this dish is also a fun way to highlight different types of wild mushrooms.

Due to my history with candida and yeast overgrowth in the body, I don't tolerate any type of yeast - based probiotic that is made from wild - fermented yeast foods, like kombucha or yeasts in bread, etc..

In fact, just today I was looking into different types of wild rice to use with it.

We talk a lot about cooking times on this site, and as with most grains (or grain - like ingredients), cooking time can vary greatly from rice to rice depending on the type of wild rice you buy, when it was harvested, and so on - so keep that in mind as you go into any recipe that features wild rice.

The type of election that coincides with or follows a special is a wild card.

«The problem with plasma cell - free liquid biopsy in particular is that the amount of wild - type [DNA] can be very, very high, and so keeping that really rare signal from being swamped out by the wild - type... is key,» says Dawne Shelton, R&D manager for in vitro diagnostic products at Bio-Rad in Hercules, California.

In addition, RNA that hybridizes with probes made from the clone is detected in wild - type S49 cells; however, cyc - S49 cells, which are deficient in Gs alpha activity, are devoid of this messenger RNA.

The fish were maintained under three conditions: individual fish housed alone with no exposure to others; fish cohoused in groups of either immune - compromised members or wild - type individuals; or mixed groups of fish with both immune - compromised and wild - type individuals together.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

«The Eliminate Dengue Program is doing field experiments to see, will we be able to replace wild - type, existing populations of mosquitoes with these Wolbachia - infected ones and does it block dengue transmission?»

Yeast grow on an agar plate in the form of the microbe's chromosomes, with colors representing whether a chromosome exists in a synthetic form (yellow) or just wild - type (orange).

The material describing wild - type development will be of lasting value to anyone working with Arabidopsis, while that describing mutant development will be a good starting place for those who are identifying new mutants.

Subsequent labeling experiments using the stable carbon isotope 13C demonstrated that wild - type L. japonicus hosts indeed directly provide the fungus with the required lipids.

Using tissue samples from five wild Amur tigers that died or were destroyed due to neurological disease in 2001, 2004, or 2010, McAloose and her colleagues proved that infection with CDV, a type of morbillivirus, is to blame for the deaths of two of the tigers and caused a serious infection in a third.

What surprised us most was that the virus replicated in the vagina of wild - type mice with intact interferon response,» said Iwasaki.

Mice with two copies of this mutation (one on each chromosome) are white; those with just one copy are significantly lighter than wild - type mice.

Results suggest tumours with multiple wild - type KRAS, NRAS, BRAF and PIK3CA genes are likely to benefit from chemotherapy plus cetuximab and to demonstrate significantly better progression - free survival, response rate and overall survival than with chemotherapy alone,» commented Ciardiello.

NGS was possible in 117 (76.5 %) patients and revealed that 66 patients had «all RAS» wild - type tumours with no mutations in KRAS; NRAS; BRAF; or PIK3CA genes and 51 patients had tumours harbouring a mutation in at least one of these genes.

However, a majority of patients with advanced NSCLC worldwide do not have tumors with these mutations (known as wild - type [WT]; no mutation detected within the gene).

While biofilm formation was abundant if the wild - type yeast was used, it was substantially reduced in animals infected with the mutant strain.

CAPRI - GOIM is a non-profit, academic, phase II trial enrolling 340 patients with mCRC and KRAS exon 2 wild - type tumours, according to local molecular pathology laboratory assessment.

Prof Andrés Cervantes, Biomedical Research Institute, INCLIVA, University of Valencia, Spain, ESMO spokesperson, not involved in the study, commented: «This is a new understanding of how to treat a select group of patients that are wild - type for the KRAS, NRAS, BRAF and PIK3CA genes who can be treated with the same anti-EGFR antibody and a change in chemotherapy following progression.

When animals were infected with both S. mutans and either the wild type or defective mutant yeast strains, the researchers observed clear differences.

This is because, on treating with the antibiotic ampicillin, no inflammation was observed in wild - type SPF mice with the induction of TH1 cells as described above, but it was caused in IL (interleukin)-10-deficient SPF mice.

Biotechnologist James Dale and colleagues at Queensland University of Technology in Brisbane, Australia, cloned a resistance gene named RGA2 from a type of wild banana that's impervious to TR4 and inserted it into the Cavendish, creating six lines with varying numbers of RGA2 copies.

In neurons of DIXDC1 mutant mice (center) the dendrites — neural antennae that receive input from other brain cells — have fewer of the dendritic spines (white with red arrows)-- the receiving half of most synaptic inputs — compared to dendrites in wild type mice (left).

Domain recombination also led to changes in mating phenotype, including recombinants with increased mating efficiency over the wild type.

The three molecular super clusters of lower grade gliomas have either: • Wild - type IDHI1 and IDH2 with no mutations.