Sentences with phrase «with zonisamide»

UPDRS Part III scores were significantly lower with zonisamide than with placebo (weighted mean difference [WMD], — 2.56; 95 % confidence interval [CI]; — 4.20 to — 0.92; p = 0.002).

Not exact matches

Of those treated with a single medication, nearly all were treated with one of five medicines: Levetiracetam, oxcarbazepine, phenobarbital, topiramate and zonisamide.

Further, zonisamide significantly decreased the wearing - off time compared with placebo (standardized mean difference, — 0.24; 95 % CI, — 0.39 to — 0.09; p = 0.001).

Risk may be higher with long - term treatment (12) and concurrent use of carbonic anhydrase inhibitors such as topiramate or zonisamide (24).

Zonisamide can be prescribed as a lone therapy, but it is most commonly given as an add - on medication with either phenobarbital or potassium bromide.

Zonisamide can be used by itself as well as combined with other anticonvulsant medications.

Zonisamide can be used alone or in combination with Phenobarbital and / or potassium bromide for treating seizures.

As with most anticonvulsant drugs, however, Zonisamide can cause drowsiness, incoordination (loss of muscle control), and a depressed appetite in dogs.

While Zonisamide appears to be relatively safe for dogs, is effective in controlling seizures, and is well - tolerated, many veterinarians are still concerned that we may not know the entire range of side effects possible with the drug because its use has been somewhat limited so far.