Sentences with phrase «within cells and tissues»

The joint pain and muscle soreness you feel is due to boating within your cells and tissues.

It is therefore not wise to «provoke» the body to rapidly dump mercury, lead and other toxic metals out of their hidey holes deep within the cells and tissues.

This chemical technique allows us to visualize the expression levels and distribution of specific proteins within cells and tissues.

Not exact matches

The building block electronic and protonic actual occasions are, in the case of human beings, swept into vastly more complex, Chinese box - like sets of containing societies within which there are social levels that can be identified with cells, others which answer to Aristotle's levels of tissues and organs, and which finally are presided over by what Whitehead refers to as the regnant nexus, a social thread of complex temporal inheritance which, Whitehead suggests, wanders from part to part of the brain, is the seat of conscious direction of the organism as a whole, and answers to what in Plato and Aristotle is called the soul.

Intermittent fasting allows the body to shed off inferior cells and dump toxins out of the fat cells and deep within organ tissues.

The fields within biology are further divided based on the scale at which organisms are studied and the methods used to study them: biochemistry examines the fundamental chemistry of life; molecular biology studies the complex interactions of systems of biological molecules; cellular biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms interrelate.

Researchers at the Center for Engineering MechanoBiology (CEMB), an NSF Science and Technology Center at the University of Pennsylvania, study plants like this Arabidopsis thaliana to learn how molecules, cells and tissues integrate mechanics within plant and animal biology, with the aim of creating new materials, biomedical therapies and agricultural technologies.

The technique examines the small molecules, or metabolites, within cells, bio-fluids, tissue, or organisms and their interactions within the larger system, called a metabolome.

Despite being trapped and baked within a polymer, cell staining shows that the cultured cells remained alive, says Fernandez, an obvious necessity if they are to be used for artificial tissues.

The term «in situ» means that the cancerous cells are contained within the breast's milk ducts and have not invaded the surrounding tissue.

«We looked microscopically at the lung tissue of horses that died during or just after races, and quantified the inflammatory cells within their airways,» said Prof. Luis Arroyo, Department of Clinical Studies.

Information encoded within these structures helps cells recognize each other and relay messages in virtually every tissue

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

Researchers are already using single - cell analysis to identify genetic variations within tumors and tissues, and Langsdorff says the technique is quickly establishing a foothold in microbiology as well.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils.

This «wound - healing» aspect of the immune response stimulates growth of new cells within damaged tissue and brings extra nutrients and oxygen into the injured tissue.

Within a few weeks, the mesenchymal stem cells have been modified to form cartilage tissue, and within months, the site becomes calcified, forming natural bone containing bone marrow Within a few weeks, the mesenchymal stem cells have been modified to form cartilage tissue, and within months, the site becomes calcified, forming natural bone containing bone marrow within months, the site becomes calcified, forming natural bone containing bone marrow cells.

This similarity suggests that the proteins could promote cell growth and development in target tissue within the female's body and as a result influence female reproductive behaviour.

Interdisciplinary research at the University of Pennsylvania is showing how cells interact over long distances within fibrous tissue, like that associated with many diseases of the liver, lungs and other organs.

Therefore, these «self - reactive» T cells survive destruction within an organ called the thymus, the central immune organ in which T - cells mature, and attack healthy cells and tissues, including melanocytes.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weeks.

The natural structures that exist either between cells or within cells are damaged during the freeze - thaw process and hence the flavor or texture of the tissue is altered.

The ability of cancer cells to change position within body tissues through cell migration and invasion represents the biggest threat of cancer to human health.

The cells originate outside the central nervous system in the ectoderm of the body wall and appear to migrate to their final locations within the central nervous system by crawling along strands of connective tissue.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

One theory has been that calorie restriction slows age - related degeneration and enables more efficient tissue function by influencing the integrity and activity of adult stem cells, the precursor cells that dwell within specific tissues and give rise to the diversity of cell types that compose that tissue.

«By looking comprehensively at gene expression within cells, we can now spot numerous important differences in complex tissues like the brain that are invisible today,» said George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School.

«We designed a technique able to image molecular organization in cells and tissues that can ultimately let us see the early stage of this detachment and how lipids are organized within this myelin sheath,» said Brasselet.

This process requires a fundamental change in the character of cells within the primary tumor, insofar as members of a localized cell mass must be converted into actively migrating cells that invade into the surrounding tissue and blood vessels, and finally settle in distant tissues.

They observed similar results in ART - controlled, HIV - infected patients who had undergone elective abdominal surgery: their SVF samples are positive for HIV DNA, and the researchers could show the presence of infected and virus - producing cells within the patients» adipose tissue and more specifically among adipose CD4 + T cells.

Low temperatures activate the brown - fat thermogenesis process via the sympathetic nervous system: Nerve ends in brown fat tissue release the neurotransmitter norepinephrine, and that triggers a shift in metabolism within the brown fat cells, which are densely packed with tiny biological energy reactors called mitochondria.

Previous reports suggest that obesity alters the mononuclear phagocytic cell content in the circulation and within adipose tissue.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

The safe use of a stem - cell - based therapy against brain metastasis would require preventing the engineered cells from persisting within the brain, where they could affect normal tissue and possibly give rise to new tumors.

According to the researchers, these findings suggest that differences in shape from cell - to - cell within a tissue are key to their ability to jam and unjam — and that this process appears to drive biological events including embryonic development, wound healing, and, potentially, cancer cell invasion.

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

Figure 2 shows sets of results for four areas of human corneal endothelial tissue; central endothelium (defined by endothelial cells within a 4 mm trephined boundary), central - intermediate endothelium (defined by endothelial cells within an 8 mm trephined boundary), intermediate - peripheral endothelium (defined by endothelial cells between the 4 mm trephine edge and 12 mm from the center of the corneal endothelium), and the peripheral endothelium (defined by the 8 mm trephined edge and 12 mm from the center of the corneal endothelium).

We use physiology, histology, and molecular biology to understand development and disease on a holistic basis, all the way from the individual to the organ to the tissue and finally to the molecules within cells.

We will also utilize laser capture of encysted parasites within neuronal cells in human brain and eye tissue to characterize mRNA transcriptomes of parasites, host and contiguous cells in situ.

«Human cells are unlikely to behave entirely normally within a chimera,» said Knoepfler; cells from the host species are far more prevalent, providing the blood supply and connective tissue, for instance.

Participation of Ukraine and in particular the Institute of Cell Therapy in the implementation of the international scientific project THYMISTEM within the prestigious framework of the EU is the sign of very high achievements of our scientists in the field of cryobiology, immunology, tissue engineering.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

The encapsulation of pancreatic islets within mainly alginate - based macro - or microcapsules with various physical configurations may allow protecting the islet graft without the need for immunosuppressive agents and moreover expanding the donor pool to animal tissue and novel insulin - producing cells.

With the award - winning work, Sebastian Zeißig's group demonstrated that bacteria within the normal gut microbiota can invade the intestinal tissue and activate an enzyme in stem cells that facilitates stem cell growth and cancer development.

Researchers have for the first time been able to measure directly how a compound interacts with its target within the cell and even within patient tissue.

This might be feasible for muscle, where there are stem cells that are responsible for cell turnover within the tissue, but it will be very difficult for heart and brain cells, where cell turnover is very low or non-existent.

Cells and tissues acquire complex morphological and functional polarity features, which, remarkably, are highly precisely positioned within the general body landmarks.

The aim is to provide new insights into heterogeneity and division of labor within tissues or communities of cells from all domains of life.