«This is the very first time researchers have looked at the proportions of mutations
within different cancer types and assigned them to these three factors,» said lead author Cristian Tomasetti, assistant professor of biostatistics at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins Bloomberg School of Public Health, referring to heredity, environmental and random factors.
Not exact matches
Even
within the same
cancer type,
different tumors can respond differently to
cancer drugs, and some tumors do not respond at all.
The study analyzed data from The
Cancer Genome Atlas (TCGA), a research program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of c
Cancer Genome Atlas (TCGA), a research program supported by the National
Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of c
Cancer Institute and National Human Genome Research Institute
within the National Institutes of Health that is looking at genomic changes in more than 20
different types of
cancercancer.
We see extensive variability in genomes among tumours of
different tissue
types, among
different patients
within a tissue
type and among subclones
within a given patient's
cancer.
• Detect Zika virus in blood and urine samples
within hours and distinguish between its African and American strains • Distinguish between Zika and dengue • Discriminate
different types of bacteria, like E. coli • Detect
cancer cell mutations • Detect antibiotic resistance genes • Read human genetic information from saliva sample
Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between
different cell
types found
within tumors, or to study tumor evolution during
cancer development or after
cancer treatment.
It means that
cancers are not the same — between
types of
cancers, between
cancers in
different individuals, even between
cancer cells
within the same person.