Not exact matches
But as the research in Yaniv's lab progressed, it became clear that scientists on both sides of the argument had been right: Lymphatic
cells do indeed grow from veins, but they originate from a
niche within the vein that harbors angioblasts.
Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature — the small blood vessels that transport blood
within tissues — as a
niche where dormant cancer
cells reside.
Understanding the role of the
niche requires identifying the key
cell types that regulate the numerous processes that take place
within the
niche.
Stem
cell populations reside in areas called
niches deep
within different types of organs.
But how the production of daughter
cells from the different stem
cell types is coordinated
within a single
niche is virtually unknown.
Her goal is to define the molecular architecture and functional significance of a
niche, determine how tumor growth impacts the
niche, learn how benign and malignant
cells compete
within a
niche, and use this knowledge to design precisely targeted anti-cancer treatments that spare normal bone marrow and improve the efficacy of stem
cell - based therapies.
In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «
niches,»
within the bone marrow and how normal, healthy hematopoietic stem
cells, which give rise to the many kinds of blood
cells, compete with malignant
cells to occupy these coveted
niches.