Sentences with phrase «within photoreceptor»

Not exact matches

They found that the neural synapses within the retina began to deteriorate even before the photoreceptors started to die.

The illness occurs when a DNA mutation within one of the genes affects the normal ocular development or induces photoreceptor — the cones and rods - degeneration.

While preservation of the ONL is evidence for a neuroprotective role for hNPCctx and GDNF within the retina, maintenance of visual function at the level observed in this study suggests at least partial retention of photoreceptor structure necessary for visual processing, particularly that associated with cones.

(E) Low power view of a retina section obtained from the same eye used in panel A showing extensive rescue of photoreceptors within the outer nuclear layer (ONL) after subretinal injection of hNPCctx — GDNF.

Both unmodified and genetically modified groups were found to have cells that migrated and survived in two distinct locations: (i) as a separate, nearly continuous, subretinal layer lying between the host RPE and photoreceptors, and (ii) as individual cells distributed throughout the neurosensory retina, especially within the inner retinal layers (Figure 5A).

Human neural progenitors survive as two distinct populations within the retina and promote photoreceptor rescue.

Importantly, akin to HESC - RPE in vivo, cells at the outside edge of the iPS - RPE cell bolus could phagocytose photoreceptor outer segments from the RCS rat, as indicated by the presence of rhodopsin - positive photoreceptor material within the cellular membrane of iPS - RPE labelled with HSM (Fig. 5E).

Phagocytosis of photoreceptor outer segments was defined by the inclusion of rhodopsin - labelled material within the TRA -1-85-bordered intracellular compartment of grafted human iPS - RPE cells.

Within this broad topic we are particularly interested in characterising (i) the molecular mechanism by which these photoreceptors mediate light - dependent entrainment of the circadian clock, (ii) the components mediating, in a light - quality - dependent fashion, nucleocytoplasmic partitioning of phytochromes and UVR8, (iii) how phosphorylation and sumoylation of these photorecepors and other signalling components modulate red / far - red and UVB - induced signalling, and (iv) to what extent intercellular and cell - autonomous events contribute to phytochrome and UVR8 regulated photomorphogenesis.

However, the evidence from the past decade or so has revealed a third class of photoreceptor within the eye; intrinsically photosensitive retinal ganglion cells (ipRGCs), which express their own distinct opsin — melanopsin [6,7].

To further examine the morphology of cells and the localization of protein expression within the retina, immunohistochemical staining of both paraffin and OCT retinal sections was performed with the following antibodies (Table S1): human cone arrestin (for cone photoreceptors), rhodopsin (for rod photoreceptors), RPE65 (for the retinal pigment epithelium, RPE), glial fibrillary acidic protein (GFAP, for astrocytes and Müller cells), glutamine synthetase (for Müller cells) and G0alpha (for ON bipolar cells).

(D) Accumulation of autofluorescent material (green) within the RPE can also be seen in a well preserved region of a 13 - year old Stage - 2 affected retina (arrow), possibly indicating that increased autofluorescence may precede loss of photoreceptors.

(C) At the transition between relatively well preserved and completely absent (*) retinal architecture, loss of photoreceptors (cones are labeled red with hCAR antibody) is associated with accumulation of autofluorescent material (green) in the subretinal space and within the RPE (arrows).