Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going
on within tumor cells.
The discovery of an unexpected biochemical
link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human studies, the researchers said.
He is investigating the possibility that the vaccine induces chromosomal
change within those tumor cells that manage to escape the immune attack, and that the change makes remaining tumor cells more vulnerable to chemotherapy.
Selectivity of the therapeutic approach is achieved by producing an enzyme called E. coli purine nucleoside phosphorylase (PNP)
directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself.
Developing strategies to inhibit this
signaling within tumor cells could help restore T cell access and enhance the potential of immune - mediated cancer treatment.»
Revealed that the loss of the human leukocyte antigen (HLA) locus in lung cancers is a way these tumors evade the immune system and allow mutation expansion and branched evolution within tumor cells
So we were surprised to discover that immune cells follow the same signals of blood vessels and nerves to position
themselves within the tumor cell and, in doing so, contribute to tumor growth.