Sentences with phrase «within tumor microenvironments»
Learn how dendritic cells maintain a local antitumor immune response within the tumor microenvironment
http://www.sciencemag.org/
For instance, we previously demonstrated that DGKζ - deficient T cells demonstrate partial insensitivity to several important mediators of immune inhibition within the tumor microenvironment, including PGE2 (12), adenosine (12), TGF - β (13), and PD - L1 (10).
The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.
The earliest came from a landmark study in 1998 by Haruo Ohtani, M.D., who demonstrated that the presence and location of CD8 + killer T cells within the tumor microenvironment (aka «tumor - infiltrating lymphocytes,» or TILs) correlated with better outcomes in colon cancer.
Levels of viral replication and evidence of viral - induced immune activation within the tumor microenvironment were monitored.
Not exact matches
Recently, there has been progress in the treatment of patients with malignancy through targeting receptors on the surface of CD8 + T cells that inhibit their activity within the highly suppressive tumor microenvironment.
Microenvironment - Driven Shift of Cohesion / Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma.
Several soluble factors released by stromal cells within the bone microenvironment promote tumor growth and survival (27).
These data suggest that ABL kinases promote breast cancer metastasis to bone in part by increasing tumor cell survival within the bone microenvironment.
The Vaccine & Immunotherapy Center brings together many outstanding researchers within the Institute to focus on new immune based approaches to induce protective tumor immunity, to control the tumor microenvironment, and to use humoral and cellular immunity to control or eliminate cancer.