Sentences with phrase «within tumors»

Viruses have been found within these tumors in some cats but, as far as we are aware, they do not cause the tumors.

Bottom row shows confirmation of the presence or absence of HB1.F3 NSCs within tumors by PCR detection of a DNA amplicon (293 bp) of the v - myc transgene, a unique identifier of the HB1.F3 cell line.

The loss of HLA often occurred relatively late in the tumors» evolution and resulted in an expansion of neoantigens within the tumors, predicted to bind to the lost HLA allele.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

The goal of this center is to bring radiotherapy into the era of personalized medicine by identifying genetic markers of radiotherapy resistance and uncovering how heterogeneity within tumors affects radiotherapy efficacy.

2004: IMRT (Intensity Modulated Radiation Therapy) Program began to deliver high - precision radiation that conforms to the three dimensional shapes of tumors and delivers higher and well defined doses of radiation to tumors, and even specific areas within tumors, while minimizing radiation to surrounding normal tissue.

Using a combination of biochemical and genetic approaches, Darnell's lab discovered that the immune systems of PND patients thwart tumors with what is essentially an antiviral response: The patients» T cells produce CD8 + killer T cells that recognize the neuronal antigens present within their tumors.

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

Previous studies have found that patient survival decreases as genetic diversity within tumors increases.

I believe there are three highlights: frequent gene alterations in TNBC, under - representation of mutations in mRNA sequences, and a continuous distribution of mutation frequencies within tumors.

Microenvironment - Driven Shift of Cohesion / Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma.

Within tumors, there exists a subpopulation called the «cancer stem cells» (CSCs).

When activated by VTX - 2337, TLR - 8 prompts dendritic cells within tumors to secrete factors that fuel a cascade of immune responses.

To assess whether changes in T cell numbers within the tumors could be responsible for the observed differences in tumor size, we processed the spleen and tumors from mice and calculated percentages of CD4 + and CD8 + T cells.

This apparently symbiotic relationship within tumors has provocative implications for the study and treatment of human cancers.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Strikingly, female mice had three times more microglia within these tumors than male mice.

Gutmann stressed that boys with NF1 also experience vision loss, just not as frequently as girls, and that male NF1 mice harbor some activated microglia within their tumors.

While previous research had shown some effectiveness of this molecule in a mouse model of ovarian cancer, that benefit was limited by the immunosuppressive environment within tumors, particularly the presence of regulatory T cells (Tregs).

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.

«The big surprise,» Discher said, «is that injected macrophages circulate all around the body but accumulate only within the tumors where they engorge on cancer cells.»

Special strains of the adenovirus, the researchers say, have been altered to deploy anticancer genes within tumors, killing cancer cells while leaving healthy ones unscathed.

Cancer stem cells (cells within the tumors that can renew themselves) may drive metastasis.

«There are a lot of genetic differences within tumors,» said Townsend, «and different mutations appear in different metastases.»

«Within 24 hours we see really impressive replication and spread within tumors.»

The bacteria the group found, explains Straussman, live within the tumors, and even within the tumor cells.

Researchers are already using single - cell analysis to identify genetic variations within tumors and tissues, and Langsdorff says the technique is quickly establishing a foothold in microbiology as well.

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

Others have found that bacteria within the tumors themselves can influence the effectiveness of traditional chemotherapy as well.

The favorable composition of flora were associated with a «higher activation status» of their killer T cells within the tumor compared to those who had an abundance of Bacteroidales.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

Previous studies have examined cancer stem cells (CSCs)-- small populations of cells within a tumor that are resistant to chemotherapy.

«In pancreatic, ovarian and liver cancers, we hope that by adding anti-cancer stem cell drugs to standard of care, we can control proliferating cells within the tumor that could otherwise help the tumor regenerate in the face of existing chemotherapies.»

«In this way, we gain a precise insight and can also observe the activation of different metabolic pathways within the tumor,» says Dr. Marcel Krüger, one of the first authors of the study.

Within a tumor, some cells were red and some were green.

The nanoparticle, according to the scientists, helps the drug slip through capillaries near cancer cells and remain within the tumor longer than it would otherwise.

She even found evidence that the devils» immune systems were occasionally performing this interferon - gamma trick themselves: In some instances, tumor cells near the edge of the tumor, in close proximity to white blood cells, showed MHC antigens that cells farther within the tumor mass lacked.

Their stem cell - like properties enable them to maintain a pool of cancer stem cells within the tumor, as well as to produce new mature tumor cells.

«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.

The discovery of an unexpected biochemical link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human studies, the researchers said.

The overlap and density of these lymphocytes within the tumor and peripheral blood offer novel prognostic biomarkers for this deadly disease,» adds Richard Koya, MD, PhD, Associate Director of the Roswell Park Center for Immunotherapy and Director of the Institute's Vector Development and Production Facility.

In NSCLC there are specific genetic abnormalities within the tumor that can be exploited with drugs specific for the molecular abnormality.

«Gene therapy approaches fall into two main categories: (1) the transfer of a gene that stimulates the immune system and (2) the insertion of genes within the tumor that sensitizes the tumor to a relatively nontoxic «prodrug.»

«Our findings suggest a simple strategy to kill metastatic melanoma — regardless of cell type within the tumor — by combining anticancer drugs with diabetes drug,» Herlyn said.

The researchers used computer models to predict that small changes of the pH within the tumor could tip the balance, decreasing the survival advantage of the invasive cells in favor of the non-invasive cells.

These genetic differences have often been blamed when chemotherapy or other treatments have been unsuccessful, as it was believed that the therapy may not have targeted all of the cells within the tumor.

It both promotes angiogenesis within the tumor and increased the migration of endothelial cells, which form the inner lining of blood vessels.