Sentences with phrase «within tumours»

Recent evidence indicates that non-cancerous support cells within tumours, referred to as the stroma are emerging as key sources of tumour - promoting inflammation, but little is known how or when in tumour evolution these functions are acquired.

That's the new picture emerging from recent studies, which suggest that a small number of stem - cell - like cells within tumours give rise to all the rest of the cancerous cells.

Olaparib was licensed in December for women with ovarian cancer and inherited BRCA mutations, but the new research suggests it could also benefit men with genomic faults within their tumours.

This then leads to remarkable genetic diversity within the tumours.

The researchers, at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, say their test is the first developed for a precision prostate cancer therapy targeted at specific genetic faults within tumours.

The suggestion is that a small number of such cells within tumours may be the precursors to the other cancer cells in those tumours.

New research on bowel cancer has shown that every tumour is different, and that every cell within the tumour is also genetically unique.

Evolutionary biology could help us outmanoeuvre the enormous genetic variation found within each tumour

Then rare cells within the tumour mutate further and...

These drugs can be targeted to interfere with signalling within the tumour microenvironment or activate other processes which will kill the cancer cells.

These mice models allowed me to study the importance of STAT3 within the tumour and the overall tumour microenvironment.

Although these processes are affected by many different cell types within the tumour stroma, macrophages and other myeloid - derived cells are among the most important players.

Not exact matches

I'll give real life examples of nocebo, from the man who almost put himself in a coma after «overdosing» on placebo anti-depressants, to the patient mis - diagnosed with liver cancer who died tumour - free within the three months he was told he had left to live.

Within 24 hours, the team found that H. pylori was causing the organoid cells to divide twice as fast as normal, and activating a particular gene, c - Met, that can cause tumours.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

By measuring levels of a modified protein, they could identify those who went on to develop secondary tumours within two years, with more than 90 per cent accuracy.

Within that sting lies a peptide called chlorotoxin, which has an unusual property — it sticks strongly to tumour cells while ignoring surrounding healthy tissue, by binding to a cancer - specific protein called matrix metalloproteinase - 2.

According to Eckmann, «The special thing about these processes is that they involve known molecules with very long evolutionary histories, previously receiving attention as suppressors of tumour formation within the context of normal cell division.

If everything goes according to plan, they will soon be able to localize the tumour within a few millimetres range, with the help of the research scientist Erlend Fagertun Hofstad, the engineer who is co-piloting the navigation at the computer screen.

Most solid cancer tumours that have outgrown their blood supply, and are therefore deprived of oxygen, are difficult to treat, and the cells within are capable of spreading rapidly and doing the most damage.

In addition, they showed for the first time that these genes are often the same as those that are altered in breast tumours - when a tumour develops, the DNA within the cancer cells themselves mutates.

Saurabh Saha of BioMed Valley Discoveries in Kansas City, Missouri, and his colleagues wondered whether they could use the bacteria to selectively kill mammalian cells within cancerous tumours, which often have a poor blood supply and therefore low oxygen levels.

«Some of these genes were either increased or decreased in the area of the tumour, no matter the type of breast cancer, and this is important because within the patterns we identified were predictable alterations.

«In this particular case we can see that blood flow tends to decrease in those who will survive longer without symptoms, whereas for those whose symptoms will recur within six months, we saw blood flow to the tumour increase after their treatment.»

Most people with glioblastoma multiforme die within a year of diagnosis, as standard treatments can not eradicate these tumours.

«Females do not find a mating partner within the small isolated populations any more,» explains Petra Kretzschmar, scientist at the Leibniz Institute for Zoo and Wildlife Research (IZW), «the long non-reproductive periods lead to the development of reproductive tract tumours.»

This accuracy really shows up in areas such as radiation treatment for cancer, where the dose delivered to the patient's tumour needs to be accurate to within 3 per cent to achieve the best outcome.

When they loaded sperm cells with doxorubicin, a common chemo agent, and released them in a dish containing mini cervical cancer tumours, the sperm swam towards the tumours, killing 87 per cent of their cells within three days.

FORTY per cent of people who have had cancer see it return within five years of tumour removal, but a gel may change that.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumour develops, and how its progression is regulated», says Ingegerd Elvers.

In the future, scientists hope to target stem - cell - like cells within cancers that may be responsible for most of the growth of some tumours, and evade existing drugs.

The tumour killing functions of Natural Killer cells require energy and to meet this demand NK cells take on more fuel, which they burn within a metabolic engine to drive energy production.

The average of number of vessels within the whole section and the vessel area were correlated to the total tumour area.

We see extensive variability in genomes among tumours of different tissue types, among different patients within a tissue type and among subclones within a given patient's cancer.

«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can label many specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour cells but how they interact with their surroundings.

In the mouse experiments no tumour formation was found (within 100 days).

This research concerns the investigation of both the micro - and macro-cosmos with applications within environmental studies and medicine for example, such as the diagnosis and treatment of tumours.

They are seeking a Scientific Officer 2 to jointly work within our Tissue Biomarkers Team and Tumour Immunology and Inflammation Monitoring Laboratory Team (TIIML) to assist in the development and implementation of tissue biomarkers to monitor immune status and responses.

Many in vivo processes, including morphogenesis or tumour maturation, involve small populations of cells within a spatially restricted region.

We construct a statistical model that separates fragile sites from regions showing signatures of positive selection for homozygous deletions and identify candidate tumour suppressors within those regions.

Conserved regions include the IR1 latency promoter (Wp), and one zone upstream of and two within BWRF1.IR1 is heterogeneous in 70 % of strains, and this heterogeneity arises from sequence exchange between strains as well as spontaneous mutation, with inter-strain recombination more common in tumour - derived viruses.

Within the scope of personalized medicine, this technology presents immense possibilities for testing patient - derived multicellular tumour spheroids / organoids (comprising cancer cells, stromal cells, cancer stem cells and / or immune cells) for disease / biomarker - oriented drug activity and profiling using single - and pair-wise standard / targeted drug combinations.

In studying variations within the repeat of each strain, we identified a mutation in the main laboratory strain of EBV that impairs virus function, and suggest that tumour - associated viruses may be more likely to contain DNA mixed from two strains.

Although these tumours do not spread, they can press on sensitive areas within the brain and cause serious health problems.

A tumour that originates within the brain itself is a primary brain tumour (as opposed to a secondary brain tumour that starts elsewhere in the body but spreads to involve the brain).

One theory proposes that once the storage capacity of subcutaneous adipose tissue (SAT) depots is exceeded under conditions of energy excess, either as a result of impaired expandability and / or excessive hypertrophic growth, fat deposition within visceral depots and non-adipose tissues including the liver, skeletal muscle and pancreas can ensue.93 This can subsequently lead to the development of systemic IR and a series of associated cardiometabolic disorders including dyslipidaemia, dysglycaemia, hyperinsulinaemia and hypertension.3 Expression of pro-inflammatory mediators including interleukins 1 (IL - 1), 6 (IL - 6), tumour necrosis factor alpha (TNF - α) and resistin, are also increased which can further potentiate IR and promote atherosclerosis.

A study published a couple of years ago, for example, showed that «chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape.»

They include diseases of the cornea (keratitis), the lens (cataract), increased pressure within the eye (glaucoma), any disease which reduces retinal sensitivity to light impulses (retinal atrophy), or any disease which affects the optic nerves or the sight - center of the brain (tumours, trauma).

Acromegaly — this is an unusual condition of older cats the place a tumour within the pituitary gland secretes too much progress hormone.

Tragically, by the time the cancer was diagnosed the tumour was inoperable and despite undergoing extensive treatment our client passed away within a year of diagnosis.