This has potential applications for cell replacement
without the immunosuppression treatments that are required when cells are transferred between genetically different individuals.
Not exact matches
While difficult to achieve, immune tolerance — in which a transplanted organ is accepted
without long - term
immunosuppression — can be induced in some patients.
Although maintenance
immunosuppression remained unaltered, there was a resolution of tubulitis
without IF / TA in both patients.
Thus, one can transplant fully allogeneic hematopoietic stem cells and co-transplant, for example, hearts from the hematopoietic stem cell donor to induce lifelong donor - specific acceptance of the transplant,
without deleterious
immunosuppression [4].
In a related study, recrudescence of non-cultivable B. burgdorferi following antibiotic treatment was attempted by transient
immunosuppression of the mice with corticosteroids
without apparent consequence [15], but that outcome would be expected when spirochete burdens in tissues are under control of antibody.