Sentences with phrase «without knowing their function»

We've now shown that our new method will allow us to explore the organizational structure of neurons without knowing their function in advance.»

As for the Sestrins, without knowing their function, it's difficult for us to say how easy they would be to target, but I think the more possibilities you have, the greater the potential is for finding viable drug targets.»

We included genes with and without a known function in olfactory and vomeronasal signaling that cover the whole range of expression values observed (Table S1).

Not exact matches

Until then, private sales (without intermediaries) were a function of the buyer and seller's knowing each other, or spotting the other's lawn sign or ad in the local newspaper.

On the one hand, says Haff, we can no longer live without the «support structure and the services provided by technology» — the communication, transportation, energy, and other networks that developed to make human life on an increasingly crowded planet function in the first place.

No, he went further and argued that the traditional separation of functions in the Canadian financial system were coming apart with or without government policy changes.

Tim i found it liberating to just do what the Lord wants you to do i work within his boundarys and yes i attend church and enjoy it.I love the people and i love hearing the word and worshipping the Lord even if others are still bound up with traditions thats not my walk thats theres.My focus is to do what the Lord wants me to do.There have been times i have said no to the pastor he does nt understand why i choose not to lead the worship.i query him as well regarding the idea that its not just performing a function because there is a need our hearts have to be in the right place so that the Lord can use us but he did nt understand where i was coming from and thats okay because of that i just said no until my heart is right i am better not being involved in leading.But i am happy to be an encouragement to others in the worship team i havent wanted to be the leader i have done that in the past.So my focus has been just the singing and being part of different worship teams i think the Lord has other plans as the groups i am in seem to be changing at the same time i am aware that i do nt to worry about change as the Lord knows whats best.I used to be quite comfortable leading the music but that was before when i was operating in my own self confidence and pride.The Lord did such a huge change in my life that i lost my self confidence and that is not a bad thing at all as my spiritual growth has been incredible.The big change was my identity moved from me and what i could do to knowing who i was in Christ and that he is my strength and confidence.Now i know that without him i can do nothing in fact i am dependent on his empowerment through his holy spirit all the time in everything.In the weekend i was asked to lead the music at another church i attend multiple churchs although i attend two regularly one has services in the morning and one has services in the evening so the two do nt really clash.In the weekend i was asked to lead the music its been two years since i did that and i was worried on how i would go.All i can say is that it went really well and because i stepped out in Faith the Lord really blessed the morning to the congregation.The difference is knowing that i serve the Lord with the gifts he has given me but my heart has to be right and when i do it in his way it builds up the body and it brings glory to him.May the Lord continue to show you what he wants you to do even though others may not understand your reasons i just want you to know that you do nt have to pull away completely just work within the boundarys that the Lord gives you and do nt feel pressured by others expectations to do anything that feel uncomfortable.Be involved just as you feel lead by the holy spirit even if it is in a very minor way take small steps.regards brentnz

If you know the Bible and God then you will realize the utter insanity of johns own thoughts to the point you wonder how this person who lies, speaks without knowledge tries to mislead even functions in society.

Simply that our North American culture could hardly function as we know it today without color TV, while the loss of the electric oven hood would scarcely be missed.

fred... yes fred, i have a better way — but you sir, i have no need to keep this conversation going, for you are terribly thick headed, and beyond brainwashed by religion... you claim to believe the bible and what is has to say yet allow for me to be a di - ck to god without fear of recourse or any form of punishment from god — back in the day, i would have been smoted, now you losers claim that he will just torture me forever in hell as my punishment — this implies that god has learned better ways to function as god — whoa, did anyone else just see what i said, god learned... thats rather un-godly, to learn, being he is all knowing - but your right, i am wrong... jesus christ where did i put my fuk you card, oh god - dam - nit... i must have thrown it away with all the other garbage i don't use... well too bad.

Anyway, I have been on the paleo diet for about 8 months (accidentally — I was quite sick for a while — but now I know I just function better without grains and sugar etc.).

A component of our service is to include and educate people without disabilities so they may gain the benefit of knowing how to interact with their peers regardless of functioning level.

The tactics of 4 -1-4-1 has led the players astray, meaning they do not know crap about the formation so the run around the place without any direction > The players role in this formation have not been define, what i am basically saying they do not know what is their function (what to do)

That might sound funny, but at the bottom of a lot of intense homesickness is the sense that «Without me there, my family won't know how to function.»

Society in turn has watched as the «available parents» have volunteered to fill that roll in schools, and rewarded those parents with the «Good Parent Awards» instead of asking the question «what's wrong with our classrooms that they can no longer function fully without additional adult help?»

With a keen eye for designing stylish and sleek products that combine features and functions new parents want?plus innovations they never knew were possible, the MESA works directly with the VISTA smart luxury stroller and the CRUZ stroller systems without the purchase of adapters.

We know that from the 1970s to today, productivity and labour income have decoupled; we have gained productivity without increasing wages, which means that our most important redistribution tool, labour income, has ceased to function.

After this, the No campaign began properly functioning with its two key aims: To convince every Tory to vote no without undermining the effort to divide the Labour vote.

There's even tare functions if you want to know how much your stuff weighs without the weight of your bag added in.

And without knowing tankyrase's exact function, it's «too early to tell whether [the enzyme] is a good target for drug discovery,» cautions telomere expert Calvin Harley of Geron Corp. in Menlo Park, California.

This process resembles what happens when boiling an egg, but now without heat: proteins that normally need to carry out essential functions for the bacteria — such as digesting their food — clump together and can no longer carry out their work.

But the clinical problem — for the physicians, at least — is identifying gait issues, as it can be difficult to support a patient's mobility functions without knowing their true extent.

With the exception of a slight difference in bowel function, investigators found that HRQoL outcomes for patients on AS were no different than those in men without prostate cancer during the three years of followup.

People with diabetes are also known to be more prone to depression, memory loss and eating disorders than people without diabetes, and imaging studies have shown that people with diabetes have altered brain function compared to those without.

They may provide as much as three times the amount of base variation as the better - known single nucleotide polylmorphisms (SNPs), where single base pairs vary between individuals without affecting function.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

While on the Clean Program, you eliminate foods that are known to cause digestive issues or even allergic reactions, with the hopes that it will reset your body to function beautifully without them.

If someone has provided you a service, take a minute to ask his or her name and let him or her know you wouldnâ $ ™ t be able to function without that cup of coffee or late - night ride home.

During that time, 7.2 % of the men and 5.7 % of the women developed the mental - function problems known as mild cognitive impairment (MCI), with or without any accompanying memory loss.

If someone's ever gone four, five - ish hours without food and they've heard that grumbling, that gurgling in their stomach, that's a motility function known as a migratory motor complex.

When the lymphatic system is functioning properly, wastes are removed from the cells and infections are dealt with quickly and efficiently, often without you ever knowing that you were even exposed to toxins or an infection.

But, what most men don't know is that without a properly functioning cardiovascular system, things below the belt aren't going to function either.

I have a tremendous amount of energy and I know my cells are cleaning up house WITHOUT compromising the function of my hormones, and I know without a doubt this has helped me to shed some serious baby WITHOUT compromising the function of my hormones, and I know without a doubt this has helped me to shed some serious baby without a doubt this has helped me to shed some serious baby weight.

Without proactively caring for your brain, your chances of suffering from severe deficits in cognitive function at some point in your life are about 50/50 — no better than a flip of a coin.

Day 11 — Wake Up and Smell the Coffee It may seem quite obvious that coffee is considered a functional food — I know I can't function without coffee!

And without properly functioning insulin, you will have trouble losing weight no matter how much you restrict your calories.

She knew from that very first experience that she wouldn't be able to function without it again.

Fish oil is a known nootropic — it's able to improve and enhance neural function and cognition without negative side effects.

On the bright side, my symptoms weren't drastic so I know that I can enjoy a piece of bread once in a while without huge damage, but I know that I function much better without it, so I now only cook meals without gluten and have so much fun experimenting with my healthy recipes that don't irritate my gut!

While anxiety and depression are characterized as mental health disorders rather than physiological illnesses, this really is a distinction without a difference as the functioning of the brain is a direct consequence of biochemical reactions that are no less dependent on physical aspects of our bodies, than our hearts and lungs are.

Health is not just the absence of some known disease, but your entire body functioning without any problems — that means your body is free of aches and pains, has abundant energy, and your mind is sharp and clear.

No matter what the reason, without sufficient sleep you won't be able to function normally — especially if it's a regular occurrence.

«If sending messages had a price or you could send only a fixed number per day, people you contact online would know you had to give up something to do so, which would incentivize better behavior,» he says.Perhaps beyond just charging for messages, sites could adjust the price according to how high quality someone's engagement seems to be.Unfortunately, without a full membership you can't respond to or block other users, use the chat function or see who has viewed your profile.If you upgrade to a paid account, guarantees you'll find someone special within six months of membership.

The parallels between Grace's mission and the American «experiment» in Iraq, that is, creating a functioning democracy among people who have never known self - government (and perhaps don't want to know it), without institutional infrastructure, are obvious.

Unfamiliar with symbolism - laden allegory, and without knowing how allegories function as social critiques, most students manage only a surface - level comprehension of the text, missing the opportunity to explore the larger ideas of human capability and culpability.

Without the BRAKE lamp illuminating during the vehicle start up bulb - function check, the driver has no confirmation that the lamp is working and therefore may not know whether or not the lamp will illuminate if the brake fluid level is low.

Reassignment is a form of reasonable accommodation that must be provided, absent undue hardship, to an employee who, because of a disability, can no longer perform the essential functions of the position s / he holds, with or without reasonable accommodation.

(76) This type of reasonable accommodation must be provided to an employee who, because of a disability, can no longer perform the essential functions of his / her current position, with or without reasonable accommodation, unless the employer can show that it would be an undue hardship.

Sitting at jeep now 6,600 miles with a bad speed sensor, trans issues etc LOOK IN THE FORMS - Read the real reviews - the 4cyl is a FIAT engine - trans has known problems since 2014 — trying to see what i can do to get out of this vehilcle without takeing to big a hit — yes i know i picked a bad combo that yields poor mpg and power but this thing is beyond issues and flaws — nice looks poor function....

Without straying from its main purpose, this is an ereader, I'd be curious to know what cool functions they feel are being left out in the name of battery life.