Sentences with phrase «without presenting modeling»

(6) Based on what is known about the behavior of the antibody and the available pharmacokinetic data, Prothena CEO Gene Kinney has stated (albeit without presenting modeling to support the assertion) that «we would expect to fully saturate that pathological load [of aggregated AS] in patients with Parkinson's disease.»

Not exact matches

There he says, one, that the shift from the concept of «the State's role as providers of equal opportunities to every citizen» to that of providing education, health and other social services «to those who can afford to pay» is a U-turn in public policy which «has been made surreptitiously by administrative action without public discussion and legislative sanction»; two, that the total commercialization of social sectors is «alien even to free market societies»; and three, that «the ready acceptance of self - financing concept in social sectors alien even to free - market societies is the end result of gradual disenchantment with the Kerala Model of Development», which has been emphasizing the social dimension rather than the economic, but that it is quite false to present the situation as calling for a choice between social development and economic growth.

It presents the Kerala model as something from which the Union Government and other Indian states like UP and Bihar have to learn their lesson that without a basis in social development like literacy, health and women's education and social security there can be no participatory economic expansion which is necessary if economic growth has to serve society.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

Therefore, results are presented for models without interactions.

The film presents a lot of statistics — almost more than can be taken in on one viewing, in fact — about the state of manhood in this country, but it also shows examples of what parents and teachers and coaches and other role models can do to raise men who can be strong and powerful without shutting off their feelings.

Even if the e-Learning market is still considered a «niche» segment within different HR macro segments it is subjected, in both a positive and negative manner, to the influences of sales trends related to smart devices and the increasing spread of the Internet access globally.Other opportunities come from Smartphone devices, considered valuable assets that help improve work productivity, and the concept of Mobile Learning, and ultimately «BYOD» (Bring your own device) a slower trend, but one that will be ongoing for some time.A Breakthrough... without borders!The SaaS Business Model is increasingly present in educational reform, and technology plays a significant role in presenting a key opportunity for education suppliers globally.

I'd like to test a base model LR4 sans the $ 18,000 worth of options this one arrived with because frankly, looking at the options list here, there aren't many of add - ons I find especially necessary, but perhaps I would miss them more than I think I would if presented an LR4 without them.

The risk presented by a side - impact collision in a VX fitted without side airbags is reduced by 50 percent when compared to a similarly specified VT model.

I have had this model for several years now, and found it to be perfect for what I need as I can highlight and add notes respectively, I was given as a present the new version without the keyboard last year, but totally useless for adding notes or highlights, so is now housed in a drawer somewhere, as most of the literature that I read is on a study base, I feel I will have to revert back to hard copy for my research, please start manufacturing this model... perfect in every way

It has a totally flat glass screen, without the raised plastic bezel that is present on cheaper models, and the screen is high - resolution, with 300 pixels per inch.

A brand new bedrock bodily model of Minecraft for Switch will launch the day earlier than the replace goes reside, and present homeowners of Minecraft on Switch can replace to the brand new model without spending a dime.

Dr Rotstayn says that «what our model is suggesting is that these droughts in the Sahel in the 1970s and the 1980s may have been caused by pollution from Europe and North America» and the commentary goes on to say «if his model is correct...» So the science is certainly not presented without caveats, and nowhere do we simply state that global dimming is unquestionably the cause of the Sahel drought.

At the same time, analyses of observational data from the late nineteenth century to the present performed in this paper and in Ashok et al. (2003), as well as some modeling work (Behera et al. 2006; Bracco et al. 2005; Lau and Nath 2004; Fischer et al. 2004), indicate that the dipole events can sometimes occur without ENSO.

OK, so if I abandon computer modelling and merely extend the present temperature graphs into the future with an HB pencil and a school ruler, am I in practice «modelling» the future, albeit without using a computer?

At the same time, however, there are many wonderful organizations that model sustainability at its finest, working to develop systems that meet present - day needs without compromising the abilities of future generations to support themselves.

However, in my paper I have argued that if the long term of the solar variability falls down and the Moberg temperature data are correct, the actual models are very wrong because they will never be able to reproduce the millenaria cycle presented in the Moberg data without a strong climate sensitivity to solar cicle.

This does not make any huge difference to the model but shows 1958 was considered then changed to 1975, without any reason being presented.

Even more importantly, unless they can actually be shown to be «plausible», it is not appropriate to present to the impacts community without the disclaimer that they have not shown skill at predicting the climate metrics of interest when the models are run in hindcast.

In the first comprehensive biogeochemical model of this «Canfield Ocean,» Johnston et al. (2) in a recent issue of PNAS present a stunningly different take on those early photosynthesizers — one in which the upper, light - containing layers indeed drove biological production but without the expected concomitant release of oxygen.

Present that graph without the cavaets to «Joe Blow public», and (especially if he is a republican apparently) he will jump to conclusion that models can't be trusted that climate sensitivity is overestimated.

However, the heat island effect, if present, would in fact improve rather than worsen the agreement between models and observations (without it, the temperature in the most recent years would be lower, while GCMs predict a rise of temperature).

That visually appears to be similar to the climate models without AGW that was presented in IPCC AR4.

Tests with present - day models show that the assumption is valid if averages can be obtained from a very good global data coverage, even without temporal averaging.

Professor Nordhaus presents two graphs from the IPCC 2007 report2 that purport to show that without anthropogenic emissions, models successfully simulate the global mean temperature until about 1970 but can not do so thereafter.

«For many purposes that are well demonstrated with present practices, AOS models are very useful even without the necessity of carefully determining their precision compared with nature.

Within a few years, after his unprincipled, unsupported and unscientific attacks on climate «sceptics», my opinion had changed, to what it is now, that he's the very model of an unthinking and ill - informed little s ** t. Presenting «evidence» that you haven't checked out yourself is both irresponsible and unscientific, as is accepting «current thinking» or some form of consensus without questioning it in any way.

The current adjustments and hyperventilation about the biblical sanctity of the temperature and models are being done by the climate scientists and modellers who have till date not shown any skills or capability to do that job fairly and ethically and especially present results as they are, without spinning or putting a slant on them or» adjusting» them.

This sort of observation prior to the present situation should be kept in mind by people who feel competent to assert without actually doing any calculations that elimination of the Hadley Center error will improve the fit of models to data.

There is a cottage industry of people using one CMIP5 simulation, and then dynamically downscaling using a mesoscale model, and then presenting these results to decision makers without any uncertainty assessment.

Here, we (i) present data on the frequency, magnitude, and sources of lead exposure and related health effects in condors free - flying in California and (ii) develop a demographic model to estimate future condor population growth in the presence or absence of current management efforts with and without the impacts of continued lead exposure.

While the current Apple Watch models can work without an iPhone present as long as there's a known Wi - Fi network, you can't take just your Apple Watch with you and expect to have full connectivity.

Table 2 presents the results of the logistic regression model for all children, without controlling for early bullying.

The two - factor ICM - CFA model presented almost acceptable fit, both with and without covariances.

The present study compared three models of intervention: an office model, with primary care nurses providing a moderately intensive parent training program; a referral model, with clinical child psychologists providing the same parent training, and a minimal intervention treatment without therapist contact.

In the present study, as expected (Briere and Jordan, 2009), there was a medium to strong association between the environmental factors, which probably affected the cG × E, cG × cG × E, and cG × cG × cG × E. For instance, in the model that included cG × E without adjusting for the cG × cG, none of the cG × E was significant, whereas the models that included adjustment for most of the possible interactions produced significant results.

TY - JOUR AU - Lee, Eunju AU - 정익중 TI - Predictors of Deviant Self - Concept in Adolescence and Gender Differences: Applying a Latent - State Trait Autoregressive Model T2 - Korean Journal of Social Welfare Studies PY - 2012 VL - 43 IS - 1 PB - Korean Association For Social Welfare Studies SP - 5 - 29 SN - 1598 - 3854 AB - The present study was to explore what makes adolescents think of themselves as troublemakers even without conduct problems.

We, therefore, present results with and without depression included only for the self - rated health models.

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