Sentences with phrase «without tumor mutation»

The study further suggests that NSAIDs such as aspirin, ibuprofen and naproxen have a particularly advantageous effect when taken after diagnosis by colorectal, or CRC, patients without tumor mutation in the KRAS gene (KRAS wild - type tumors): The study shows that NSAID use by this group is associated with a survival benefit of 40 percent.

Not exact matches

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

The researchers found that the tumors had lost these mutations by various means, including immune - mediated elimination of cancer cells containing these mutations, leaving behind cancer cells without the mutations, or by deleting large regions of their chromosomes in all cancer cells.

Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.

CRC is the second - leading cause of cancer - related deaths in the United States, and about 70 percent of CRC patients in this study have tumors without mutations in the KRAS gene.

They divided 48 patients into two groups, those with and without these mutations in their tumors.

Overall, the pathologic complete response rate was lower among women with at least one PIK3CA mutation in their tumor compared with women without a PIK3CA mutation, but the effect was only significant among the group of women with HER2 - and hormone receptor - positive breast cancer.

Researchers found that tumors carrying mutations in the AR and FOXA1 pathways had a significantly higher response rate, 94.1 % compared to 16.6 % in tumors without the mutations.

In the replicators» hands, however, cancer cells with and without the PREX2 mutations both formed tumors within a week — not weeks as originally reported — making it impossible to tell whether PREX2 made any difference.

Just as one can't truly identify somatic mutations in a tumor tissue without a matched normal, it's nearly impossible to distinguish de novo mutations in a patient without sequencing both of his or her parents.

The Hopkins investigators found that tumors with the defect had, on average, 1,700 mutations, compared with only 70 for tumors without the problem.

(F) Immunohistochemical assay of p - ERK in tumor samples of PTCL - NOS patients with or without KMT2D mutations.

In tumor samples from PTCL - NOS patients, a significantly lower fraction of nuclear H3K4me3 positivity (+ + + ~ + + + +, 30 %) was observed in cases with the KMT2D mutation than in those without mutations.

(D) Immunostaining of H3K4me3 and H3K18ac in tumor samples of PTCL - NOS patients with or without KMT2D or EP300 mutations.

XMRV was not detected in a new set of 39 prospectively collected prostate tumors (both with or without RNAse L mutations) by PCR assays performed independently in 3 different laboratories or ViroChip microarray.

Analysis of these tumors confirmed observations that patients with mutated BRCA1 and BRCA2 genes have better survival odds than patients without mutations in these genes.