Looks like
women with PCOS can add yet another symptom to an already long list of complications associated with PCOS: Dry Eye Syndrome.
Another study showed that thin
women with PCOS who took 1,500 mg of omega - 3 for 6 months saw reductions in BMI, as well as improvements in testosterone, insulin and luteinizing hormone levels.
Ninety - six
women with PCOS were split into two groups: one group followed a low GI diet; another a high fiber diet that included whole grains.
Doses of 600 mg per day of D - chiro - inositol have been shown to improve insulin and androgen levels in lean
women with PCOS (Luorno et al. 200231), while doses of 1000 mg per day have been effective at improving a range of metabolic and cardiovascular health indicators on a more representative PCOS population (Lagana et al. 201522).
Venturella et al showed that 2 g / day of MYO for six months resulted in significant weight loss and improved HDL and LDL levels.48 MYO at 1,200 mg / day for 12 weeks significantly decreased androgens and insulin in non-obese
women with PCOS.
In a prospective, placebo controlled, double - blinded randomized trial, 45
women with PCOS were randomized to receive cinnamon supplements (1.5 g / d) or placebo for 6 months.
While high estrogen levels along with a lack of progesterone is a major factor the estrogen dominance seen in
women with PCOS, environmental factors can also play a role.
Low HDL levels are common in
women with PCOS.
This is how much they used in the study on overweight
women with PCOS I mentioned earlier, where they found that those who benefit the most are those at high risk of developing type II diabetes (see above).
Adequate intake of zinc may improve alopecia, acne, and hirsutism in
women with PCOS.
Women with PCOS can also benefit from eating nuts as they can help balance hormones and improve cholesterol and insulin.
A total of 101 infertile
women with PCOS were randomized either to combined CoQ10 and clomiphene citrate or to clomiphene citrate alone.
BPA levels have been shown in studies to be higher in
women with PCOS.
In a study of overweight
women with PCOS that were given myo - inositol + folic acid during IVF, 32 % of women had a successful pregnancy within the 12 month study period, compared to just 12 % of women who only took a straight folic acid supplement without the inositol (Artini et al. 201315).
In a double - blind placebo trial, Costantino et al showed that MYO (4 g / day) decreased insulin, triglycerides, testosterone, and blood pressure in
women with PCOS.
Carbohydrate restriction seems to be the best dietary approach for
women with PCOS.
In my view all of the positive benefits of inositol supplements are a reflection of the same mechanisms behind the scientifically proven diet and lifestyle recommendations for
women with PCOS.
Obese
women with PCOS tend to have increased free testosterone (a common type of androgen hormone) and more insulin resistance.
In the most recent study published in Gynecological Endocrinology, a randomized double - blind clinical trial involving 94
women with PCOS compared NAC 600 mg, three times a day with 500 mg oral metformin, three times a day for 24 weeks.
These study findings bring cause for concern because
women with PCOS are already at a higher risk for developing heart disease and are insulin resistant.
I mean even this study titled «The optimal diet for
women with PCOS?»
Studies show that
women with PCOS have high levels of oxidative stress.
Combating the ovulatory disorders that lead to infertility is one of the areas where inositol supplements show the most promise for
women with PCOS.
Yes, gluten can be an issue for
some women with PCOS, especially if they have Hashimotos or other autoimmune diseases, but all women with PCOS do not need to eat gluten - free.
Women with PCOS who were insulin resistant had lower levels of zinc when compared to PCOS women without insulin resistance.
Women with PCOS are bombarded with so many different diets, training programs, and so much other information that it's hard to know what to do.
Women should take advantage of resistance training because of its many health benefits, especially for
women with PCOS.
Pregnancy is an exciting time, especially because so many
women with PCOS have been trying to conceive for years.
Studies have shown that myo - inositol can improve insulin and glucose levels in
women with PCOS.
Metformin on the other hand has been studied in pregnancy with some greatly improved outcomes for
women with PCOS.
In
women with PCOS, the cellular processes that use inositol fail to function correctly.
Many
women with PCOS have found that if they cut out carbohydrates or eat very minimal amounts that it only causes them to binge eat on them in the long run.
It's recommended that
women with PCOS take a combined amount of MYO (2 - 4 grams) and DCI (50 - 100 mg) in a physiologic ratio of 40:1.
These researchers also point out that based on the results of lab studies looking at how myo - inositol and D - chiro inositol ratios are balanced in the ovary tissue of
women with PCOS (Heimark et al. 201410), it's possible that using an overwhelming amount of myo - inositol over D - chiro - inositol in a 40:1 ratio could «exert paradoxical effects».
Careful monitoring of blood sugar levels is important to prevent hypoglycemia, which a lot of
women with PCOS tend to experience as a result of elevated insulin levels.
Not that this will be news to anyone who has experienced it of course, but there are a lot of studies showing that hirsutism is a major source of distress for many of us (Pasch et al. 201626), and it's something I see discussed a lot in my Facebook community for
women with PCOS.
This finding is consistent with many other studies that have shown very modest weight loss at best when giving
women with PCOS inositol supplements.
Myo - inositol may be helping to maintain my HDL level (compared to other women of the same weight,
women with PCOS are known to have low levels of HDL).
Women with PCOS have an increased risk of developing GDM, regardless if they are overweight or not.
Lean
women with PCOS or those that don't have severe insulin resistance may not need the full dose of MYO at 4 grams / day.
In this article, I address how body composition and hormones change in women as they get older and how
women with PCOS differ from non-PCOS women (you can read a previous blog What Happens To
Women With PCOS As they Age).
Inositol is a nutrition supplement that has been shown to improve insulin resistance in
women with PCOS (you can read more about how it works here).
To my knowledge mint should be safe for
women with PCOS.
Women with PCOS who take OCPs see their periods regulate and may even see a reduction in unwanted dematological symptoms like acne and hair growth.
Don't let the name of this product fool you: Pregnitude is a myo - inositol (MYO) supplement for
all women with PCOS, not just those looking to get pregnant.
Dr. Greger mentions this study on spearmint in
women with PCOS showing in just 5 days women were able to drop their free and total testosterone levels by about 30 % drinking two cups of tea a day.
Insulin levels significantly increase in the second and third trimesters of pregnancy as a normal part of pregnancy; the majority of
women with PCOS already have high insulin levels.
Additionally,
some women with PCOS who take birth control pills report significant mood changes.
Women with PCOS who took oral contraceptives (LoEstrin) showed trends toward increased blood pressure and fasting glucose levels plus a significant increase in triglyceride levels.
A dietary intervention on obese
women with PCOS compared two different diets on weight loss.