These include low heart rate, tiredness, depression, diarrhea, low blood sugar,
worsening heart failure Low blood pressure which would cause fainting, weakness or dizziness.
Importantly, compared to placebo, treatment with FCM was also associated with a significant 61 % reduction in the risk of hospitalisation due to
worsening heart failure (hazard ratio [HR] 0.39; p = 0.009).
For example, twice as many patients treated with standard care therapies had
worsening heart failure requiring new intravenous therapies, doubling of their diuretic dose or mechanical support, compared to those treated with serelaxin.
He added: «Patients admitted to hospital for heart failure can experience
worsening heart failure despite current therapies, resulting in increased symptoms such as shortness of breath or a sense of drowning in their own fluids.
«Serelaxin reduces in - hospital
worsening heart failure, study suggests.»
Professor Marco Metra, director of the Institute of Cardiology at the University and Civil Hospital of Brescia, Italy and co-principal investigator of RELAX - AHF, said: «We have reported that all of these adverse effects of
a worsening heart failure event are related to increased overall mortality and that
a worsening heart failure event itself is related to a two-fold increased risk of dying in 180 days.»
Additionally, these patients had increased markers of heart injury and kidney dysfunction, as well as persistent congestion, compared to patients who did not experience
worsening heart failure.
The current analysis compared the serelaxin and placebo groups for the occurrence of
worsening heart failure within the first 5 days of admission to hospital.
The investigators found that within the first five days of admission, 12.2 % of patients treated with standard of care had an episode of
worsening heart failure, compared to 6.7 % in patients treated with serelaxin.
Serelaxin reduces the occurrence of in - hospital
worsening heart failure by almost half in patients admitted for acute heart failure, according to the RELAX - AHF trial.
It is difficult to predict who will have
worsening heart failure, and these events are not only immediately very discomforting to the patient, but also have other important adverse impacts.»
Not exact matches
A new study led by Massachusetts General Hospital (MGH) investigators finds that
heart failure patients who underwent bariatric surgery to treat morbid obesity had a significant reduction in the incidence of
heart failure exacerbation — a dangerous, sudden
worsening of symptoms — in the two years following surgery.
As a result, the
heart may try to pump harder, and this may lead to congestive
heart failure or it may
worsen an existing
heart failure.
More than 1 million hospitalizations for
heart failure (HF) occur annually in the United States alone, and more than 80 percent of these hospitalized patients have
worsening chronic HF.
«Not only are African American women at twice the risk, but in this study we found they also took twice as long to recover, they were twice as likely to
worsen before getting better after diagnosis, and they were twice as likely to fail to recover altogether, meaning their
heart failure persisted for months following delivery,» said senior author Zoltan Arany, MD, PhD, an associate professor of Cardiovascular Medicine and director of the Cardiovascular Metabolism Program.
Heart failure is a persistent and progressive condition that worsens over time, affecting how well the heart delivers blood to the rest of the
Heart failure is a persistent and progressive condition that
worsens over time, affecting how well the
heart delivers blood to the rest of the
heart delivers blood to the rest of the body.
Blood levels of NT - proBNP rise when
heart failure worsens and fall when it gets better.
In dogs and cats with
heart disease, loss of appetite can be due to
heart failure, side effect of one or more medications, an abrupt change in diet,
worsening kidney disease, or other diseases unrelated to the
heart.
In dogs who have already been diagnosed with congestive
heart failure and who are on furosemide,
worsening coughing and or difficulty breathing may indicate more fluid accumulation and more furosemide may be required.
This may be the result of
worsening heart disease, side effects of certain medications, or from hormone - like substances that are produced in high levels in animals with
heart failure.
Rather than exclusively relying upon more furosemide,
worsening difficulty breathing should trigger a visit to your veterinarian in order to determine whether adjustments should be made to the doses or types of medications, or to the diet, in order to better control
heart failure signs.
Proper care and monitoring of your cat at home can help delay the onset of
heart failure and help alert you if your pet's condition
worsens.
For many pets with congestive
heart failure, exercise restriction is a crucial aspect of therapy in order to reduce the risk of
worsening their condition or even death.
Your veterinarian may show you how to monitor your cat's respiratory rate at home, as an increased rate may be a sign that congestive
heart failure is developing or
worsening.
Certain medications are more likely to be associated with a reduced appetite, so check with your veterinarian to decide whether or not to try a reduced dose of one or another medication — discontinuation of the incorrect medication can lead to
worsening of
heart failure.
As the disease further progresses, signs of
heart failure ensue, including
worsening respiratory signs and cough, swollen belly and in worst cases «caval syndrome», which is a form of cardiovascular collapse.
A diet low in salt is also very important, as excess salt causes water retention,
worsening the fluid buildup that happens with
heart failure.
In some cases, specific
heart strengthening therapeutics may have a risk of
heart failure and
worsening of cardio - myopathies, (especially in older dogs with suppressed immunity).
All too often we see patients who have simply outlived their teeth, or have suffered from systemic illnesses (
heart disease, kidney
failure, etc.) caused, or
worsened by, dental disease.
In January 2013, Chad's leaky valves
worsened causing
heart failure, a buildup of fluid in his lungs.
In fact, Actos carries a black box warning concerning its potential risk of causing or
worsening congestive
heart failure.