Sentences with phrase «wt stat2»

In agreement with this, both wt STAT2 and mutant STAT2 - Y690F displayed a similar effect on the luciferase reporter gene expression in U3A cells without IFNα.

Unlike IFNα - activated ISGF3 complex in which tyrosine - phosphorylated STAT proteins are required, IRF - 9 could successfully interact with either wt STAT2 or mutant STAT2 - Y690F in the absence of IFNα, although the interaction between IRF - 9 and wt STAT2 could be obviously enhanced by IFNα via tyrosine phosphorylation of STAT2 (Fig. 2A).

B, effect of IRF - 9 with wt STAT2 or mutant STAT2 - Y690F on pXP2 (− 310) reporter gene in U3A cells.