Sentences with word «xenograft»

A xenograft is a medical term that refers to the transplantation of tissue or organs from one species to another, such as from a pig to a human. Full definition
Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient - derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics.
Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.
In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).
Acquired tumor cell resistance to sunitinib causes resistance in a HT - 29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature
We further confirmed that the protein level of APC was elevated in the human breast cancer xenograft cells transfected with the anti-miR-142-3p lentivirus (Figure 7B).
Next, we performed preclinical microPET imaging studies using ovarian cancer patient — derived xenografts in mouse models.
We further confirmed that the protein level of APC was elevated in the human breast cancer xenograft cells transfected with the anti-miR-142-3p-expressing lentivirus than those transfected with the control lentivirus in vivo (Figure 7B).
Once seeded onto a proper support, these keratinocytes appeared capable of forming a pluristratified epidermis both in vitro and in vivo as xenografts in immunodeficient mice.
To improve our understanding and to build better and more translatable in vivo mouse tumor models, we are developing humanized mouse models consisting of the transplant of patient - derived tumor xenografts into immunodeficient mice reconstituted with human immune cells (isolated from the matching patient from the draining LNs or with allogenic PBMCs or LN cells).
Age - matched female athymic NCr nu / nu mice (5 to 6 weeks old) were used for xenograft experiments.
Pearson's R2 correlation was calculated for correlation between xenograft size, HIF - 1α / Glut1, and mammosphere - forming cells (MFC).
The Reproducibility Project did attempt to replicate the mouse xenograft studies that support this second conclusion.
[37 - 39] In this study, we used HCC1806 and doxorubicin - resistant MX - 1 human TNBC cell lines xenografted into nude mice to evaluate the effects of a GHRH antagonist (MIA - 602) alone and in combination with doxorubicin.
This research was also supported by the Athymic Animal and Xenograft Core Facility and the Cytometry & Imaging Microscopy Core Facility of the Case Comprehensive Cancer Center (P30CA043703).
We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.
We provide evidence that this mechanism is also effective on human primary AML samples and xenograft transplantation.
Finally, they were also able to reduce tumor growth in their first in vivo xenograft analysis.
Personal drug regimens based on xenograft mice harboring a single patient's tumor still need to prove their true utility in medicine.
Moreover, one compound substantially decreased the growth of human melanoma xenografts in nude mice without any apparent side effects.
The ClonTracer library originally came about as Bhang and co-workers were trying to develop a way to quantify the take rate of mouse xenografts after cell implantation.
On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.
C, MCF7 xenografts were treated with YC1 by intraperitoneal injection before collection for mammosphere culture (i) and Glut1 measurement (ii).
We further confirmed that the protein level of APC was elevated in the human breast cancer xenograft formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus (Figure 7B), which is consistent with our observations using the breast cancer cell lines.
Furthermore, pyrvinium demonstrated inhibition of AR activity via selective interaction with a highly conserved DNA - binding domain and was active against castration resistant prostate cancer xenografts [75].
Zebrafish larva implanted with cancer patient's tumor (red) RITA FIOR / CHAMPALIMAUD CENTRE FOR THE UNKNOWNSee R. Fior et al., «Single - cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts,» PNAS, doi: 10.1073 / pnas.1618389114, 2017
«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»
To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.
The researchers showed that it inhibited ALDH in yeast, reduced ALDH1 activity in cell - culture spheres of mesenchymal GSCs, inhibited proliferation of glioma spheres in cell culture, and inhibited xenograft growth of GBM in mouse brains.
He developed new techniques for transplant surgery, helped to make kidney transplantation viable and was one of the first researchers to try xenografts — in the 1960s he placed baboon kidneys in six patients.
Their paper, titled «Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator - based oximetry,» was published recently in the International Journal of Cancer.
First, a single xenograft mouse is not enough.
This was true in vitro and, importantly, also in an animal model where H - Ras - transformed, mesenchymal HMLEs were used to generate xenograft tumors.
Humanised xenograft models of bone metastasis revisited: Novel insights into species - specific mechanisms of cancer cell osteotropism.
Resources include extensive genomic and drug sensitivity data sets, orthotopic xenografts and preclinical models.
Using a zebrafish embryo xenograft model we also demonstrated that anti-CD90 monoclonal antibodies decreased the viability and metastatic potential of insulinoma cells, suggesting that anti-CD90 monoclonals form a potential novel adjutant therapeutic modality.
Most xenograft models for brain tumors using tumor cell lines require at least 10,000 cells.
Multipolar Mitosis of a mouse xenograft under treatment with a prototype inhibitor of centrosomal clustering.
Fragments were rinsed with sterile PBS and xenografted subcutaneously into both flanks of each animal.
The main research activity (located in central Paris and vicinity at Orsay) regroups to date 16 technology platforms and services offering state ‐ of ‐ the - art expertise and equipment from small molecule chemistry to omcs, super-resolution microscopy, sophisticated radiation sources and various animal models, including xenografts directly derived from patients, in order to promote the best environment and support for research activities.
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