Sentences with phrase «xenograft models»
Xenograft models refer to a type of scientific experiment where human cells or tissues are implanted into different species of animals, usually mice. This helps researchers study and understand the behavior of human diseases and test potential treatments before trying them on humans. Full definition
Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient - derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics.
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Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated tumor development in xenograft models and in Sqle transgenic mice.
A quartet of samples were sequenced in this study — the primary breast tumor, the matched normal tissue, the brain metastasis (from which the patient died), and finally, a mouse xenograft model developed in «humanized» NODSCID mice.
It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].
«The ongoing line of work with this drug is an excellent example of the bench getting even closer to the bedside — our lab work with the drug in patient - derived xenograft models of disease makes possible the clinical trials taking place at the University of Colorado Hospital next door,» Jimeno says.
NSG ™ variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell...
Most xenograft models for brain tumors using tumor cell lines require at least 10,000 cells.
«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»
EZH2 inhibition delayed tumor onset in KDM6A - null cells and caused regression of KDM6A - null bladder tumors in both patient - derived and cell line xenograft models.
Humanised xenograft models of bone metastasis revisited: Novel insights into species - specific mechanisms of cancer cell osteotropism.
Using a zebrafish embryo xenograft model we also demonstrated that anti-CD90 monoclonal antibodies decreased the viability and metastatic potential of insulinoma cells, suggesting that anti-CD90 monoclonals form a potential novel adjutant therapeutic modality.
They now show that engineering hESC - and iPSC - derived NK cells with a specific HIV CD4ζ chimeric receptor enhances the suppression of HIV replication in vitro and study these cells in a mouse xenograft model [6].
The authors also thank Adrian Harris (Weatherall Institute of Molecular Medicine, Oxford, United Kingdom) for supplying the DBZ and Dr. Ciara O'Brian who produced the COB xenograft model from patient - derived metastatic cells.
We created a mouse xenograft model in which SiHa cervical cancer cells were injected into mice subcutaneously, and the resultant tumors were treated with PAL three times a week for 6 weeks.
We will use the power of modeling tumors in zebrafish in combination with patient derived cell lines and tumors and murine xenograft models to define tumor heterogeneity.
(C) In vivo effect of the CHID and DECI combination in a murine T - lymphoma xenograft model.
Patient - derived xenograft models of non-small cell lung cancer and their potential utility in personalized medicine.
Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft models.
They also found that silencing the ADAR1 gene in the xenograft model reduced multiple myeloma regeneration.
Additional experiments also showed that TiY can suppress the tumor growth in mice xenograft model.
Indeed, treatment of mice with POSTN specific DNA aptamers, single - stranded DNA oligonucleotides designed to bind and inhibit POSTN, was shown to decrease primary tumor growth and metastasis in a xenograft model of mammary tumorigenesis (Lee et al., 2013).
Using in vitro cell culture and an in vivo colorectal cancer mouse xenograft models, the laboratory is studying novel therapy combinations and interventions to help increase tumor response to treatment.
Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer tumors, and prostate cancer samples derived through mouse xenograft models.
Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.
We next developed a xenograft model of cell lines and patient - derived samples to assess the hypoxic CSC response.
In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2).
The mice continued to be monitored three times a week until 57 days after inoculation when disease symptoms (e.g. significant weight loss and hind limb paralysis) associated with this xenograft model were detected in multiple mice.