Sentences with phrase «xenograft size»

Intraperitoneal injection of the HIF - 1α inhibitor, YC1, following tumor initiation reduces the hypoxic CSC effect in MCF7 xenografts and results in no correlation between xenograft size and MFC (Fig. 5C).

Pearson's R2 correlation was calculated for correlation between xenograft size, HIF - 1α / Glut1, and mammosphere - forming cells (MFC).

To mimic the in vitro hypoxic response in vivo, we developed a xenograft model based on the hypothesis that with increasing xenograft sizes, there will be a parallel increase in hypoxia due to rapid cell proliferation and restricted blood supply to the xenograft cells.

Not exact matches

Varying sizes of xenografts were collected and analyzed for HIF1 - α expression and CSC.

Importantly, an inverse correlation was observed for ER - α — negative lines with a decrease in the proportion of MFC within the xenograft as tumor size increases (Fig. 5Bii).

These results clearly indicate that analysis of future xenograft experiments should take careful note of the size of the xenografts as well as how hypoxia influences CSC in the specific cell line used.

A, HIF - 1α and Glut1 expression in ER - α — positive (i) and negative (ii) xenografts compared with tumor size (mm3).