Sentences with phrase «xenograft studies»

All xenograft studies were conducted in accordance with the animal use guidelines from the National Institutes of Health and with protocols approved by the Dana - Farber Cancer Institute Animal Care and Use Committee.

The researchers, including scientists from The Genome Institute at Washington University School of Medicine, presented the research titled, «Patient - derived xenograft study reveals endocrine therapy resistance of ER + breast cancer caused by distinct ESR1 gene aberrations.»

Not exact matches

«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»

«There is some talk of going into 3 - D cell models rather than xenografts, because it is so difficult and challenging to grow [the transplanted tumors],» says Manish Kohli, the Mayo Clinic oncologist leading the PROMOTE study.

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

In 2012 she joined the laboratory of Dr. D.L. Konotyiannis at BSRC AL.Fleming, Greece as postdoctoral scientist, where she worked on the study of the RNA Binding Protein HuR during intestinal and lung inflammation and cancer, using inducible, KO and Tg mouse models and xenografts.

A physicist turned computational scientist, Graber comes to the MDI Biological Laboratory from The Jackson Laboratory, also located in Bar Harbor, where he focused on computational approaches to understanding post-transcriptional gene regulation and interactions, while also working intensively to process, analyze and interpret the genome - scale data sets generated within the Patient Derived Xenograft (PDX) cancer study program.

They now show that engineering hESC - and iPSC - derived NK cells with a specific HIV CD4ζ chimeric receptor enhances the suppression of HIV replication in vitro and study these cells in a mouse xenograft model [6].

Specifically, the Ignatius laboratory will study tumorigenic cell populations that self - renew and metastasize using a combination of zebrafish, murine xenograft and human cell culture systems.

On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.

A study by Pauli and colleagues in this issue of Cancer Discovery describes the creation of a precision cancer platform for patients with advanced disease, integrating DNA sequencing of patient tumors with the generation of patient - derived organoids and xenografts.

These findings are in agreement with previous studies that show that xenografts can be compromised [4], [44] even after triple immune suppression [45].

Our finding highlights a key aspect of cellular transplantation not fully addressed in many short or long - term studies of RPE transplantation: the host inflammatory / immune response to the xenograft and its indirect role in the preservation of the retina.

In his study menopausal mice were injected with xenografted human breast cancer cells.