Sentences with phrase «year cycle changes»

«we estimate that less than 23 %, at the 95 % confidence level, of the 11 - year cycle changes in the globally averaged cloud cover observed in solar cycle 22 is due to the change in the rate of ionization from the solar modulation of cosmic rays.»

Although the ions are originally involved in the development of almost one third of all newly formed particles, the concentration of the large cloud condensation nuclei in the course of the 11 - year cycle changes by only 0.1 percent — not enough to have any sizeable influence on the climate.

Not exact matches

Aaron McHardy: This is one of the biggest games we've ever made in a one year cycle, in terms of changes from last year.

There are different cycles of drivers and teams that appeal to the fan base, and that changes over the years.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.

[16:00] Pain + reflection = progress [16:30] Creating a meritocracy to draw the best out of everybody [18:30] How to raise your probability of being right [18:50] Why we are conditioned to need to be right [19:30] The neuroscience factor [19:50] The habitual and environmental factor [20:20] How to get to the other side [21:20] Great collective decision - making [21:50] The 5 things you need to be successful [21:55] Create audacious goals [22:15] Why you need problems [22:25] Diagnose the problems to determine the root causes [22:50] Determine the design for what you will do about the root causes [23:00] Decide to work with people who are strong where you are weak [23:15] Push through to results [23:20] The loop of success [24:15] Ray's new instinctual approach to failure [24:40] Tony's ritual after every event [25:30] The review that changed Ray's outlook on leadership [27:30] Creating new policies based on fairness and truth [28:00] What people are missing about Ray's culture [29:30] Creating meaningful work and meaningful relationships [30:15] The importance of radical honesty [30:50] Thoughtful disagreement [32:10] Why it was the relationships that changed Ray's life [33:10] Ray's biggest weakness and how he overcame it [34:30] The jungle metaphor [36:00] The dot collector — deciding what to listen to [40:15] The wanting of meritocratic decision - making [41:40] How to see bubbles and busts [42:40] Productivity [43:00] Where we are in the cycle [43:40] What the Fed will do [44:05] We are late in the long - term debt cycle [44:30] Long - term debt is going to be squeezing us [45:00] We have 2 economies [45:30] This year is very similar to 1937 [46:10] The top tenth of the top 1 % of wealth = bottom 90 % combined [46:25] How this creates populism [47:00] The economy for the bottom 60 % isn't growing [48:20] If you look at averages, the country is in a bind [49:10] What are the overarching principles that bind us together?

Since NEC's inception thirteen years ago, our funds have demonstrated strong performance through multiple market cycles and regulatory changes.

Additionally, the U.S. economy has dramatically changed over the past several years, with structural factors (largely the result of technological innovation and shifting demographic trends) influencing it in a manner that makes comparisons to past rate hiking cycles less relevant.

«These are cyclical changes and when the cycle does rebound — and it will — the labour shortage may be even more acute than it was a few years ago.»

«These are cyclical changes and when the cycle does rebound --- and it will --- the labour shortage may be even more acute than it was a few years ago.»

The economic cycle is measured by the change in gross domestic product (GDP), which is the dollar value of all goods and services within an economy during a stated time period (usually one year or one quarter).

As a rough guide to how prospective returns will change over the completion of the current market cycle, we presently estimate that in order to establish expected 10 - year S&P 500 total returns of 5 % annually, the S&P 500 would have to decline to the mid-1500's.

Chart 6 shows the year - over-year change in copper prices (orange line), versus the year - over-year change in the China Business Cycle Signal (blue line).

Perhaps even more significant than the increase in fringe benefits is the changing time span of people's working lives and the ratio of working to non-working years during the life cycle.

Basically we celebrate the changing of the seasons and this annual cycle is often referred to as «The Wheel of the Year.»

At Key Stage 3 (age 11 to 13 +, Years 7 to 9) schools have to teach: that fertilisation in humans and flowering plants is the fusion of a male and a female cell; about the physical and emotional changes that take place during adolescence; about the human reproductive system, including the menstrual cycle and fertilization; how the foetus develops in the uterus, including the role of the placenta.

In the past 25 years they have undertaken endless self - diagnoses which prompted cycles of curriculum change, the development of unwieldy student - faculty - staff bureaucracies and modes of governance, and all sorts of societal field experimentation.

what is necessary and a very important change for us today and the future is our conscience, and this requires global consciousness necessary for our long term needs and survival, we need a faith that will compel us to unite to address the problems of survival, in the future, a few thousand years from now the glacial period cycle is due, earth will no longer be hospitable and we either have to immigrate to other planets or, develope a system that will protect us, the natural calamities like floods, typhoons, sub zero temperatures, will become our big problem in the future, so we need a religion that will guide our conscience from simplistic self survival towards a more holistic view of reality.Our oneness with ourselves and Him is the primary tenets or doctrines of this religion.

The Scripture readings follow a three - year cycle and change every week.

We are caught in a cycle that hasn't changed in several years, but now I'm beginning to see more interest from our corporate customers.

Changes to European club competitions can only be made after three - year cycles, with the current one finishing after 2017 - 18.

Traditionally, it was a year of trying to get pregnant, but now we've changed that,» says Dr. Hal Danzer, «For women under the age of 35, for young couples, a year of trying with regular cycles, that is the diagnosis of infertility.

You're most likely to notice fibrocystic changes during your fertile years when your hormones are cycling regularly.

Each year, Wellspring Community Services helps thousands of children and families break the debilitating cycles of instability, homelessness, and adversity to achieve positive, permanent change in their lives.

P&G changed it in recent years and the smell is more potent and doesn't wash out in rinse cycles anymore.

And that's before accounting for some of the factors that the model doesn't consider: the disagreement in the polls, the unusual nature of Trump's candidacy and the demographic changes it is producing, Clinton's superior turnout operation, the possibility of «shy Trump» voters, the fact that the news cycle is still somewhat fluid headed into the final weekend, the declining response rates to polls, and the substantial number of high - profile polling misses around the world over the past few years.

· A Four - Year Term For The Legislature: Calling it a «a game changer,» Attorney General Schneiderman proposed a constitutional amendment to change the length of legislators» terms to four years, in order to end the two - year cycle of non-stop re-election fundraising and campaignYear Term For The Legislature: Calling it a «a game changer,» Attorney General Schneiderman proposed a constitutional amendment to change the length of legislators» terms to four years, in order to end the two - year cycle of non-stop re-election fundraising and campaignyear cycle of non-stop re-election fundraising and campaigning.

She said she could change her mind about the WFP line later this year or in the next election cycle.

But East Village cyclist Josh Gosciak, who's been cycling for 30 years, said that any time major traffic patterns are changed, there is bound to be an adjustment period before things calm down.

«They changed the rules on me and on this race three and half years into a four - year election cycle,» Di Napoli said.

Whoever wins next year is likely to race a stiff challenge in their first re-election in 2018, and could face continued challenges in future cycles as the demographics of the district continue to change.

«Every cycle, for the past several cycles, Democrats have talked about how this is the cycle when it's going to change, this is the year they're going to make gains at the state level,» said Matthew Walter, president of the Republican State Leadership Committee, a group that assists GOP state legislative candidates across the country.

Oddo said that up until this point, he had «zero» interest in Island BOE selections, but with a «critical election cycle» this year, he said his attitude changed.

«If you're going to change an intergenerational cycle of dysfunction and failure, you've got to take ten, 20, 30 years,» he added.

In the run up to last Thursday's London Mayoral election Sadiq Khan pledged to freeze fares on public transport for the next four years, increase spending on cycling and he has since promised to introduce a new one hour bus ticket allowing unlimited changes within an hour.

«They changed the rules on me and on this race three and a half years into the election cycle,» DiNapoli said.

If I'm president for X number of years, and there's a wave of change in the next election cycle, my like - minded justices serve as an enduring bulwark against out of control foolishness of those who don't agree with my own irrefutable wisdom.

Campaign finance rules are adopted by the State Board of Elections on a four - year cycle, Bill Mahoney of the New York Public Interest Research Group pointed out, meaning any changes could not take effect until the 2018 legislative elections or the 2022 gubernatorial election.

The state Assembly plans to change its internal rules to allow easier movement of legislation during a full two - year legislative cycle, make audio and video of committee meetings available online and give lawmakers a greater ability to move their legislation through the committee process, among numerous other changes.

However, a new study finds that the seasons are not the only thing changing Titan's atmosphere: its chemical makeup fluctuates according to the Sun's 11 - year cycle of magnetic activity.

If Lu's suggestion is correct, ozone levels should fall then rise every 11 years, in step with changes in cosmic - ray intensity driven by the 11 - year solar cycle.

Looking at shifts in Manley's winter temperatures from year to year, he says, gives a good reading of important natural cycles that influence climate, such as changes in ocean circulation like the North Atlantic Oscillation.

Cycles that drive changes in the ocean's chemistry and organisms take place over hours, days, seasons, years and even decades — timescales NEPTUNE can track.

The Sun's activity — including changes in the number of sunspots, levels of radiation and ejection of material - varies on an eleven - year cycle, driven by changes in its magnetic field.

Porco realized she was witnessing the subtle change of seasons on Saturn, where each full cycle lasts 29.4 years.

A final point: Not only does this mix of activities change each day, it changes during the course of an academic year, grant cycle, etc..

The cycle of dry spells that Pakistan has suffered for the past few years, terminated by a massive torrent, aligns almost precisely with trends predicted in the assessment reports of the Intergovernmental Panel on Climate Change.

So when the number of particles coming from the sun changes — usually as a result of its 11 - year activity cycle — it takes years before that's reflected in the amount of neutral atoms shooting back into the solar system.

With shorter cycles of extreme floods and damage, the European's current average losses of 4.9 billion euros a year could reach 23.5 billion euros by 2050, a rise of almost 380 percent, said the study in the journal Nature Climate Change.