Sentences with phrase «year trial analyses»

Not exact matches

In comparison, a meta - analysis of randomized controlled trials of artificial or low - calorie sweeteners published last year in the same journal found that their use led to lower body weight and less overall fat.

To determine the cost - effective method of delivery, from society's perspective, in patients who have had a previous cesarean.We completed an incremental cost - effectiveness analysis of a trial of labor relative to cesarean using a computerized model for a hypothetical 30 - year old parturient.

After pooling the results of 27 trials involving 165,149 people, the meta - analysis reported that people are 21 percent less likely to suffer a serious vascular event such as a heart attack, stroke or bypass surgery after their cholesterol drops by the amount that might be expected after taking statins for a year than are similar people who do not take the pills.

In 2012 in Lancet, a CTT meta - analysis of 27 randomized trials found that even among people with no previous vascular disease, those who had a 39 - point decrease in LDL had a 9 percent lower overall mortality risk over about five years.

The agency's concerns mirror those described last year in a meta - analysis of blood substitute trials.

The second study was led by cardiologist Steven Nissen at the Cleveland Clinic in Ohio; it was Nissen who, 3 years ago, set off the Avandia firestorm with a meta - analysis of 42 Avandia trials that he said suggested an increased risk of heart attack.

The findings of this study — which focused on men aged 50 to 69 years old at the baseline of the trial - are particularly striking because analyses in nutritional epidemiology usually assume a uniform effect of a nutrient.

Analysis of data from nine randomised trials involving 6756 patients (1729 older than 80 years of age) showed that alteplase treatment significantly increased the odds of a good stroke outcome (no significant disability 3 - 6 months after stroke), with faster treatment offering the best chance of recovery.

While this is a significant achievement, we need to wait until later this year when the final analysis of the trial is completed to know whether the cancers detected through screening were caught early enough to save lives.»

NIAID, which spent $ 73 million on the trial, had planned to fund it for another 4 years, but an interim analysis by an independent monitoring group led the institute to pull the plug early and announce the results.

Nearly 70 percent of the postmenopausal women in their overall analysis — a total of 36,282 individuals 50 to 79 years of age — were part of a large 2006 clinical trial supported by the National Institutes of Health and the Department of Health and Human Services called the Women's Health Initiative, which assessed the effects of supplementing with 1,000 milligrams of calcium and 400 IUs of vitamin D per day for an average of seven years.

You can't do a double - blind trial on the efficacy of a three - year course of analysis.

White and his colleagues conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, a randomized intervention of trial adults ages 45 to 76 years who were obese and had Type 2 diabetes mellitus that started in 2001.

Adam R. Glassman, M.S., of the Jaeb Center for Health Research, Tampa, Fla., and colleagues examined the incremental cost - effectiveness ratios (ICERs) of aflibercept, bevacizumab, and ranibizumab for the treatment of DME with an analysis of efficacy, safety, and resource utilization data at 1 - year follow - up from the Diabetic Retinopathy Clinical Research (DRCR) Network Comparative Effectiveness Trial.

Dr. Polonis» lab has focused for many years on functional antibodies elicited by natural infection and by vaccination, utilizing samples from multiple natural history cohorts and vaccine studies; her lab is currently performing an extensive analysis of pseudovirus neutralizing antibodies in the large RV144 follow - on trial, RV306.

We also performed subgroup meta - analyses by type of prevention (primary v secondary: in this study, trials involving healthy populations or patients with any specific disease except for cardiovascular disease were classified as primary prevention trials, and trials involving patients with cardiovascular disease were classified as secondary prevention trials), type of supplement by quality and dose (each supplement, vitamins only, antioxidants only, or antioxidants excluding vitamins), type of outcome (cardiovascular death, angina, fatal or non-fatal myocardial infarction, stroke, or transient ischaemic attack), type of outcome in each supplement, type of study design (randomised, double blind, placebo controlled trial v open label, randomised controlled trial), methodological quality (high v low), duration of treatment (< 5 years v ≥ 5 years), funding source (pharmaceutical industry v independent organisation), provider of supplements (pharmaceutical industry v not pharmaceutical industry), type of control (placebo v no placebo), number of participants (≥ 10000 v < 10000), and supplements given singly or in combination with other vitamin or antioxidant supplements by quality.

There were also no clear differences in the association between statin use and outcomes in analyses stratified by age older or younger than 55, 60, 65, or 70 years, with very similar estimates from 7 trials (eTable 6 in the Supplement).14, 19,20,26,29,31,35 None of the trials that enrolled patients older than 75 years18, 20,22,23,27,29 reported results in this subgroup.

The researchers conducted a cross-sectional analysis on a subset of nearly 400 male and female volunteers aged 65 or older who had completed a three - year osteoporosis intervention trial.

Frank Hu said, in O'Connor's paraphrasing, «the Minnesota trial was not long enough to show the cardiovascular benefits of consuming vegetable oil because the patients on average were followed for only about 15 months» and «pointed to a major 2010 meta - analysis that found that people had fewer heart attacks when they increased their intake of vegetable oils and other polyunsaturated fats over at least four years.»

Irate that columnist George Will had questioned the benefits of early childhood education in a throwaway line in paragraph 15 of an op - ed, Heckman wrote, «Those benefits, quoted by President Obama this year, come from my evidence - based analysis of more than 30 years of data from the Perry Preschool program... It is as good a trial for effectiveness as those we currently rely on to evaluate prescription and over-the-counter drugs.»

Kane's 2013 analysis, which was presented at the trial (pdf), looked at several years of data as teachers moved between schools and found that Chetty's model could accurately identify ineffective teachers and the impact they had on their students» test scores.

Though only one year of data is available for analysis at this point, the study has involved a randomized field trial of over 400 teachers and administrators broken into test and control groups.

They've developed their trading edge through years of learning and trial and error, which has developed a strong gut feel to compliment chart reading and market analysis.

Jordan's lawyers, along with the Criminal Lawyers» Association and others, had asked the Supreme Court to «recalibrate» the rather flexible legal analysis around delay, arguing that far too often cases were still going to trial despite having spent years in the system.

If the lower court finds that there was a systemic breakdown affecting this particular defendant, an indigent Vietnamese immigrant who allegedly killed another Vietnamese man and his 2 - year - old son and severely injured the man's wife in execution - style, back - of - the - head shootings, Justice Harold D. Melton wrote for the majority in the 4 - 3 decision, then that determination must be factored into an analysis of whether the defendant's speedy trial rights were violated.

In the past seven years the Supreme Court has changed the fundamental role of trial judges by expanding, in Daubert, the analyses by which trial judges admit or exclude expert testimony and by broadening, in Kumho, the scope of testimony subjected to this kind of review.

The Lex Machina Copyright Litigation Report breaks down the thousands of copyright cases filed in the last 5 years to showcase how this data can be used to inform litigation strategy: from detailed analysis of different judicial districts useful to forum planning, to timing data on trial and injunctions that can drastically improve budgeting, as well as top parties and firms for firm marketing and outside counsel selection.

Study selection and analysis: Randomised controlled trial (RCTs) comparing social skills groups with no intervention, waitlist or treatment as usual in 6 - year - olds to 21 - year - olds with ASD (DSM - IV - TR or ICD - 10 autistic disorder, Asperger's syndrome, pervasive developmental disorder not otherwise specified, Rett's syndrome or childhood disintegrative disorder).

A consortium based in the Centre for Analysis of Educational Futures at Flinders University undertook an evaluation of the two - year trial.

A study of individual cognitive therapy for bipolar disorder showed positive outcomes at 1 - year follow - up, but the benefits were reduced over time, suggesting the need for booster sessions to sustain the gains.19 As with many forms of therapy, CBT has been found to be more successful in reducing relapse in the depressive pole compared with the manic pole.30 A large randomised trial of CBT showed no difference between CBT and treatment as usual, when all participants were included in the analyses.31 However, results of a post-hoc analysis suggested that CBT was effective for participants who reported fewer than 12 prior episodes of illness and were not acutely unwell when therapy began; numbers of episodes of mania rather than depression seemed to predict treatment response.32 Such data can help guide the clinical application of CBT for bipolar patients.

Study selection and analysis: Randomised controlled trials investigating psychological treatment compared to control (waiting list, care as usual or placebo) in adults (aged ≥ 18 years) with depression (according to diagnostic interview or self - report questionnaire) and which reported treatment effects on suicidal ideation or risk, or hopelessness.

In total, 36 randomised controlled trials over the past 35 years were included in the meta - analyses, with a total of 4880 participants.

The primary outcome for the trial is the Strengths and Difficulties Questionnaire (SDQ) at 2.5 years: a sample size of 462 will have 90 % power to detect an effect size of 0.35, allowing for 25 % loss to follow - up in this intention - to - treat analysis.12

Analysis from a trial looking at 3 — 8 - year - old children in the USA also suggests that combining the parenting component of Incredible Years with child - based training and teacher training, even though more expensive, can be more cost - effective (Foster et al., 2007).