But in the past
year the drug company's shares have been one of Wall Street's biggest disasters.
Not exact matches
In the past few
years companies like Braeburn Pharmaceuticals, Intarcia Therapeutics, and Proteus Digital Health have set out to create better medical mousetraps through devices that make existing
drugs more effective.
The facility where the investigators had assembled that morning, brandishing an Administrative Inspection Warrant, was a distribution center operated by one of America's largest public
companies, the giant
drug wholesaler McKesson (mck), which ranks No. 5 on this
year's Fortune 500.
It all lends credence to Tehrani's claim that, from the outset 15
years ago, he sought to build a different kind of biotechnology firm — «a truly rational
drug development
company,» as he puts it.
The 32 -
year - old Ramaswamy has been able to sway a slew of biopharma vets to lead his
companies and take a chance on his audacious, risky approach to
drug development.
The past two
years alone have seen devastating setbacks for experimental Alzheimer's
drugs from a compendium of major pharmaceutical
companies.
Shares of pioneering CRISPR gene - editing firm Editas fell 7 % in early Tuesday trading after the
company announced that it would delay an initial FDA filing for clinical trials of one of its lead
drugs, LCA10, to the middle of next
year (Editas had originally planned to file by the end of 2017).
On average, the 30 large and small pharmaceutical and biotech
companies IDEA Pharma examined got just 11 % of their 2017 revenue from
drugs developed within the past five
years, says Mike Rea, the firm's CEO and one of the most insightful people I've met — no exaggeration — when it comes to pinpointing innovation choke points in the
drug industry.
Miller, chief investment officer at LMM, said he thinks the embattled drugmaker is «a completely different
company» than the one that was under severe fire for jacking up
drug prices, and could see returns of 25 percent to 30 percent per
year over the next five
years.
Sarepta Therapeutics, which won a pioneering Food and
Drug Administration approval for its Duchenne muscular dystrophy drug last year, has settled a patent dispute with rival BioMarin over the «exon - skipping» technology at heart of the companies» muscular dystrophy treatme
Drug Administration approval for its Duchenne muscular dystrophy
drug last year, has settled a patent dispute with rival BioMarin over the «exon - skipping» technology at heart of the companies» muscular dystrophy treatme
drug last
year, has settled a patent dispute with rival BioMarin over the «exon - skipping» technology at heart of the
companies» muscular dystrophy treatments.
MONTREAL — Valeant Pharmaceuticals faces
years of legal challenges despite cutting ties with a U.S. mail - order pharmacy at the centre of a controversy about how Canada's largest publicly traded
drug firm conducts its business, say industry observers and the
company's second - largest shareholder.
The
company took advantage of a number of U.S. programs meant to spur «orphan
drugs,» or treatments for the kinds of disorders that afflict less than 200,000 Americans each
year.
Weston said his family, who also controls Loblaw's parent
company, George Weston Ltd. (TSX: WN), has undergone some major changes in the past
year, including the $ 12.4 - billion blockbuster acquisition of the Shoppers
Drug Mart chain.
Vas Narasimhan, a trained physician and former McKinsey consultant who is now global head of development at Novartis, has pursued a wide range of roles in his seven
years at the
drug company.
Before the insurance
company pays a penny toward
drugs, she and her husband have to spend $ 7,000 each
year.
Through its more than 9,800 retail locations, more than 1,100 walk - in medical clinics, a leading pharmacy benefits manager with more than 94 million plan members, a dedicated senior pharmacy care business serving more than one million patients per
year, expanding specialty pharmacy services, and a leading stand - alone Medicare Part D prescription
drug plan, the
company enables people, businesses and communities to manage health in more affordable and effective ways.
«Shoppers tends to be a Top Five
company, but last
year was a low point for them with the fight for generic
drugs,» says Susan Quinn - Mullins, a senior adviser to the Research Institute.
Walmsley has been in place for around a
year, but has already replaced nearly half of GSK's top executive team and has made sweeping changes in its R&D team, while shutting down many of its clinical
drug trials in an effort to narrow the
company's portfolio.
And after announcing a «social contract» to keep
drug price hikes below 10 percent a
year, his
company raised a slew of prices by 9.5 percent.
In November, Denner helped facilitate the sale of hemophilia
drug maker Bioverativ, for $ 11.6 billion, to Sanofi, a little more than a
year after the
company was spun out of Biogen, of which Denner is a director.
Concerns that a Hillary Clinton administration would impose greater price regulation on
drug companies had put a damper on pharmaceutical stocks for more than a
year.
Only about 200 patients or fewer will take Valeant's branded version of the migraine
drug this
year, amounting to less than $ 1 million in sales (about 0.01 % of the
company's annual revenue).
After generic
drug maker Actavis bought Allergan last
year, it took the name of the specialty pharmaceutical
company; the reinvented Allergan then turned around and sold its legacy generic business to Teva Pharmaceutical Industries (TEVA) in July.
The
companies have begun to market their «biosimilar» (a generic version of expensive biologic
drugs) of Remicade — a copycat of J&J's best - selling rheumatoid arthritis and immunology treatment (which garnered more than $ 5 billion in U.S. sales last
year) and was approved by the Food and
Drug Administration (FDA) in April — at a striking 35 % discount to its list price.
Revenue growth has slowed as many
companies sink more resources into developing the next blockbuster
drug; what's more, the «patent cliff» for the last round of megabillion - dollar
drugs — when generics firms typically see a sales spurt — happened a few
years ago.
(Currently, there is a shortage of Valeant's Nitropress, a heart
drug that is off - patent but has no generic version — despite the
company having tripled the
drug's price «overnight» last
year, according to the House committee.)
Numerous
drug companies have been criticized for the increased prices of some medications in the past few
years.
LONDON, Feb 6 - After nearly a century building a
company worth $ 125 billion based on injectable
drugs, Denmark's Novo Nordisk - the world's biggest insulin maker - wants to prove this
year it can transform the diabetes market with a pill.
ASH 2016 has been one of the most anticipated scientific conventions of the
year, with
companies like Novartis, Kite, and Juno presenting critical new data about a next - gen set of
drugs that are being tested in numerous blood cancers.
A Wall Street Journal investigation earlier this
year linked
companies controlled by Canada
Drugs through its wholesale division to a shipment of a fake cancer
drug, though the FDA hasn't reached a conclusion.
While Yervoy brought in $ 960 million in sales in 2013 (an enormous figure for a two -
year - old
drug with a small patient population), the
company currently has more than 35 ongoing clinical trials investigating another
drug that disengages the immune system's brakes: the much - awaited nivolumab, which was also from the Medarex portfolio.
Eagle's Sassouni pointed out that since the big
drug companies are losing billions of dollars every
year to generic versions and have little to spend on their own research and development, they are looking to buy smaller biotechnology
companies that are developing their own products.
Yes, the model that most major
drug companies are hoping to emulate these days isn't Pfizer (No. 51 on this
year's Fortune 500), but rather Bristol - Myers Squibb, No. 176 — which is down from No. 158 in 2013 and a rank of No. 134 the
year before.
When Sarepta Therapeutics nabbed a pioneering approval for a Duchenne muscular dystrophy (DMD)
drug last
year, it won more than just bragging rights and a controversial FDA approval: the firm also landed a coveted «priority review voucher,» which can either be sold off to another
company or used to slash the review period for a future Sarepta treatment.
Shares of the
drug company have falling since the middle of last
year on allegations of account fraud and price gouging.
For months, if not
years, people wondered how Pfizer, the
company that sold the
drug, would survive after its cash cow of a pill stopped providing the milk.
The investors are frustrated that shares in Jazz, a $ 9 billion pharmaceutical
company known for its narcolepsy
drug Xyrem, have remained essentially flat over the past
year.
According to Ackman, Valeant has spent $ 40 billion acquiring
drugs or
drug companies in the past five
years or so.
Now Mylan appears to be learning the same hard lesson this week that Martin Shkreli and Valeant (vrx) learned last
year: Investors love when pharmaceutical
companies raise
drug prices — until everybody else gets really upset about it.
The price of the EpiPen has soared 500 % since generic
drug company Mylan (myl) bought the treatment nine
years ago.
This is quite a big deal as Valeant bought Sprout Pharmaceuticals, the
company behind the
drug for a whopping $ 1 billion just over two
years ago.
After
years of buying up
companies then raising the prices of their
drugs — a strategy that rapidly amplified Valeant's revenue and stock price — Valeant is now struggling to grow by other means, while dealing with the consequences of its previous actions.
Cindy Whitehead, the founder and COO of the Raleigh, North Carolina - based
company, has been fighting to get the
drug approved for four
years.
The campaign also said that Prop 61 «would invalidate many
drug discount agreements the state has negotiated with pharmaceutical
companies,» which would increase state prescription costs by tens of millions of dollars each
year.
Looking at the portfolio, the
company's Innovative Health segment, which sells newer, patent - protected
drugs, contributed sales of $ 7.42 billion, representing growth of 5 %
year over
year.
But the
company was hit by regulatory and political scrutiny in the past
year over its
drug pricing and its relationship to a mail - order pharmacy, and its stock took a beating.
Profit declines sharply and
company cuts full -
year outlook
Cardinal Health Inc. reported a sharp decline in profit in its last quarter and lowered its full - year outlook following inventory write - downs in its overseas businesses and a sharper - than - anticipated decline in generic drug prices.
Such big winners stopped showing up a few
years ago, leaving the large
drug companies watching the calendar for the day when earnings would be hurt by the loss of key patent protections.
However, I believe that new
drug approvals, a solid pipeline and the
company's deals and acquisitions will pave the way for growth this
year
Over the past three decades, the Tufts Center for the Study of
Drug Development has estimated both the cost and the
years it takes for
companies to develop new medicines.