Sentences with phrase «years impacted the development»

This study is the first to determine whether solitary drinking during teenage years impacted the development of alcohol use disorders as young adults, after controlling for other known risk factors.

Not exact matches

In the opinion of the Company's management, a discussion of loss reserve development is meaningful to users of the financial statements as it allows them to assess the impact between prior and current year development on incurred claims and claim adjustment expenses, net and core income (loss), and changes in claims and claim adjustment expense reserve levels from period to period.

Underlying combined ratio represents the combined ratio excluding the impact of net prior year reserve development and catastrophes.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Several Thai politicians who attended the Boao Forum for Asia, a kind of China - centered version of the World Economic Forum in Davos, noted that, in recent years, some of the discussions at Boao had shifted from a kind of general talk of globalization and its impact in Asia to more specific conversations about some of the failings of Western economic models exposed by the global economic crisis, and whether China's type of development might be less prone to such risks.

The most directly comparable GAAP financial measure is the combined ratio, which is computed by adding total incurred losses and LAE, including the impact of catastrophe losses and loss and LAE reserve development from prior years, with the insurance expense ratio.

Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.

Cigna's outlook excludes the impact of additional prior year reserve development and potential effects of any future capital deployment.5

The news is sure to have an impact far beyond the executive offices at Uber's headquarters on Market Street in downtown San Francisco: the company has been reportedly planning to go public, perhaps as early as this year, and that development could be impacted either positively or negatively by Kalanick's departure.

Multipliers are frequently used in offsetting to compensate for the risk of failure of the offset measures and the time lag between when negative impacts of the development project are felt and the positive impacts of offsetting come to fruition, often a period of many years.

What is true when you examine the development of equity crowdfunding in all of these jurisdictions outside of North America is that it took two years before equity crowdfunding started to have an impact.

Oil sands development is a matter of provincial government policy: in a government policy paper (the Mineable Oil Sands Strategy) issued a few years ago (and since recalled), the core area of the oil sands resources in Alberta was designated a «sacrifice zone», within which it was acknowledged that significant and irreversible environmental impact would be permitted to occur, to enable the realization of the significant economic benefits such development promised.

Strong candidates will have 1 - 3 years of consulting, M&A, strategy, or corporate development experience out of a first - tier undergraduate program and find intrinsic reward in an unstructured environment where individuals define their roles, own their actions and have outsized impact.

Until a few years ago, any one of these developments would have impacted oil prices.

He goes on to compare the impact registered by Ford's moving assembly line 100 years ago with the developments in today's self - driving technologies.

Excluding the impact of revenue reportability, adjusted development margin was $ 36 million, an $ 11 million increase from the prior year quarter.

Excluding the impact of revenue reportability, adjusted development margin was $ 35 million, a $ 3 million increase from the prior year quarter.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

A distinction of greater consequence was in process of development during these years, but its full impact upon the work of the minister was not to be felt until a later period.

Relating to this year's WTPO Conference theme - Trade and Investment Ecosystems: Delivery for Growth - this award recognises the successful use of integrated partnerships and networks to advance export development and impact.

Kirsteen Campbell, master blender for The Famous Grouse explains: «Within two years we see significant colour and character development, with a sherry cask having a greater impact than a Bourbon barrel, as sherry casks provide a higher level of flavour compounds to be extracted by the maturing grain whisky.

«These developments have negatively impacted our profitability, and as a responsible business we have to act to remove the impact of these new developments, and the action we are taking is a three - year transformation program which cuts across our whole business and sets out to restore our profitability.»

Referred to as the «Oscars of Innovation,» the R&D 100 Awards honor products and technologies released in the last year that make a significant impact within the research and development community.

The SENSE tool can be used for (i) environmental impact assessment of the product, (ii) food chain hot spot identification, (iii) comparison of hypothetical or real improvement scenarios, (iv) assessment of the environmental impact development over the years, (v) benchmarking opportunity for the companies, and (vi) a business to business communication strategy.

«These developments have negatively impacted our profitability, and as a responsible business we have to act to remove the impact of these new developments, and the action we are taking is a three - year transformation programme which cuts across our whole business and sets out to restore our profitability.»

This includes Corporate Social Investment, whereby the group promotes the development of learners through three academies which offer holistic, full - year programmes centred around sport, art and education; Entrepreneur Development which focuses on skills - based entrepreneurial development through its Tsogo Sun Book a Guesthouse and Supplier Development programmes; and Environmental Education, committed to initiatives that reduce the impact the business has on the edevelopment of learners through three academies which offer holistic, full - year programmes centred around sport, art and education; Entrepreneur Development which focuses on skills - based entrepreneurial development through its Tsogo Sun Book a Guesthouse and Supplier Development programmes; and Environmental Education, committed to initiatives that reduce the impact the business has on the eDevelopment which focuses on skills - based entrepreneurial development through its Tsogo Sun Book a Guesthouse and Supplier Development programmes; and Environmental Education, committed to initiatives that reduce the impact the business has on the edevelopment through its Tsogo Sun Book a Guesthouse and Supplier Development programmes; and Environmental Education, committed to initiatives that reduce the impact the business has on the eDevelopment programmes; and Environmental Education, committed to initiatives that reduce the impact the business has on the environment.

The 21 - year - old has already spent time out on loan with Feyenoord and Burnley in the past, and as he struggles to make an impact at the Britannia he looks set to continue his future development away from England.

I remember the doctor from the Czech national team saying he needed a significant amount of time to sort out a problem that occurred in his development, and I'd suggest it has had a big impact on his injury prevalence over the years.

I have followed with interest developments over the last few years in the emerging field of impact sensors: small microchip - sized accelerometers and gyroscopes embedded in mouth guards, chin straps, skull caps, ear buds, skin patches and attached to the inside and outside of helmets which, in either send data to sideline personnel or flash an alert about a heavy hit.

* Preliminary results from an Oxford - based study suggest a higher proportion of infant - directed negativity in the way depressed fathers talk about, and to, their infants (Sethna et al, 2009) * Depressed fathers are less likely to read, sing songs and tell stories to their babies than other fathers — and than depressed mothers (Paulson et al, 2006), which may explain why fathers» depression has a more powerful negative impact than mothers» depression on their infants» language development in the first year.

After following closely developments in the impact sensor area for a number of years, and believing that this cutting edge technology had the potential to revolutionize the sideline identification of concussion in contact and collision sports and combat the chronic underreporting of concussions by athletes (which a new study has just shown persists, despite increased education), we decided to beta test the Shockbox football helmet sensor (one of the sensors nearing market launch).

PS 116's principal Jane Hsu told DNA Info that the school «spent over a year «analyzing studies focused on the effects of traditional homework» and decided that it was more important for the Pre-K through fifth grade students to do activities that «have been proven to have a positive impact on student academic performance and social / emotional development» such as reading at their own pace and playing.»

Jerome Kagan, a Harvard professor of psychology, spent years researching the way in which a baby's innate temperament impacts a person's development over time (Kagan & Snidman, 2009).

He and Grych went through some 30 years» worth of academic research on parenting styles and strategies and their observable impact on the character development of children to write «Fostering Goodness.»

«There are a several factors that inform speech and language acquisition and skill level — one of which is hormonal influences that impact brain development in early childhood, particularly during the first three years of life.»

The early years are tremendously important in a child's development, and right now the way we deal with the education of children in those years is very low - impact, to the point of being non-existent, in many places.

Because so much brain development takes place during the teen years, it is important that parents understand the impact that social media use can have on their kids.

Maureen has over 20 years experience leading resource development and marketing to drive growth and mission impact for organizations.

When severe behavioral issues are introduced into these formative years, it can make a negative impact on healthy development.

Unfortunately, many parents face obstacles — such as those caused by stress, language barriers, geographic and social isolation, poverty, and their own adverse childhood experiences that leave them without a positive parenting model — that impacts their ability to fully support their baby's development during these critical years.

Whether infants cry intensely for a few months or fuss frequently for the first year of life, a systems approach to development would suggest that the impact of extremes in crying on the infants» immediate environment may have negative consequences for the dynamics of the parent - child relationship, which in turn would have implications for the child's psychosocial development.

Research overwhelmingly shows that screen activities have a negative impact on early development (language, motor, attention, social, etc.) and nearly every professional organization devoted to the health and development of children has made recommendations against screentime below 2 years of age.

There are unique considerations regarding the needs of infants during the first three years of life which are highlighted by contemporary knowledge, underscoring the impact of early experience on the development of human infant brain and mind»

Apps and Technology: Technology should be used sparingly during the early years due to its impact on neurological development.

Many countries have implemented national policies that prioritize and value the unique and irretrievable impact that parents have in the early years of their child's development.

First, fathers» interactive play during toddlerhood has been longitudinally associated with attachment security in later childhood and adolescence.17 Second, fathers» speech and language interactions with infants have been positively associated with language development, and paternal depression has been shown to adversely impact this process.18, — , 20 Third, discipline practices, such as corporal punishment, have been longitudinally associated with increased child aggressive behavior.21 In addition, paternal depressive symptoms have been longitudinally associated with harsh paternal discipline practices in older children and subsequent child and adolescent maladjustment.11 Finally, as an indicator of fathers» interactions with pediatric providers, we also examined the proportion of depressed fathers that reported talking with their children's doctor within the previous year.

«In recent years, the commercialisation of infant feeding has impacted on professional practice through the development of sponsorship by the Baby Feeding Industry of medical conferences and meetings, along with gifts to health workers.

This year's conference season will probably have a bigger policy impact than any of the following five, because 2013's discussions and debates can still genuinely shape manifesto and policy development, which will have largely crystallised by the following year.