Sentences with phrase «years of trials involving»

What can we conclude about the role of IV vitamin C after 33 years of trials involving at least 1,600 patients?

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

A new book on the Canadian workplace — Work on Trial: Canadian Labour Law Struggles, edited by Judy Fudge and Eric Tucker — provides an engaging and accessible account of various labour battles in the courts over the past 85 years involving human rights, employment fairness and union recognition.

The readers, which were tested during a trial involving 40 churches last year, are capable of supporting 500 transactions without recharging, although the vast bulk of regular donating is expected to continue by standing order.

Involved with these considerations is the question of the year in which the last supper and the trial and crucifixion of Jesus took place.

For the very lucky, you only have to clean up a small pond's worth of pee over the course of a few weeks before you're in the clear, but for most people, potty training a kid involves a series of trials and tribulations that can take months (or in some cases years; our thoughts are with you).

Talk about ethics reform in the new legislative session has been largely muted this year, even as a year filled with corruption trials involving prominent New York figures is underway, including the ongoing trial this week of Joe Percoco, a former close aide to Governor Andrew Cuomo.

Next year, a former top aide to Gov. Andrew Cuomo, Joe Percoco, will go on trial along with the former president of SUNY Nanotech and upstate developers, who are accused of being involved in a bribery and bid - rigging scheme for economic development projects.

The Silver retrial is the second of four corruption trials involving state government to take place this year.

«Your brother did not die in vain,» stated Cuomo of Brodwer's brother Kalief, who committed suicide in 2015, two years after being released from Rikers Island, where he had spent three years awaiting trial on charges involving a stolen backpack.

DeFrancisco, 71, immediately emphasized what he sees as the governor's vulnerabilities: several economic development projects in upstate New York that have sputtered, chronic delays in the New York City subway system and a corruption trial involving the 60 - year - old governor's close confidant Joe Percoco — the first of six trials this year involving state figures.

After 6 weeks of studying the over one year court proceedings on the ongoing trial involving four suspects; Osarfo Anthony, Ekow Micah, Sarah Kwablah, and Chris Handler, accused of allegedly conspiring to extort money from Asamoah Gyan, the new Attorney General headed by Madam Gloria Akuffo, is set to appear in court for trial to continue.

Next year will also feature two federal corruption trials involving some of Cuomo's top allies: Alain Kaloyeros, the former president of State University of New York Polytechnic Institute, and Joe Percoco, who managed Cuomo's past two campaigns and has been likened to a brother.

Another corruption trial scheduled to begin this year involves Alain Kaloyeros, who was president of SUNY Polytechnic Institute and is accused of rigging bids for projects part of the «Buffalo Billion,» one of Cuomo's top economic development programs.

The year after his trial, the U.S. Supreme Court, in a case involving Bob McDonnell, ex-governor of Virginia, narrowed the types of official actions that would constitute quid pro quo.

Nine people have pleaded guilty or been indicted in connection with alleged bid rigging and other corruption charges involving some of Governor Cuomo's economic development programs, and they face trial later this year.

«I've been involved in clinical trials for 30 years,» says the study's lead author Bonnie Ramsey, a professor of pediatrics at the University of Washington School of Medicine in Seattle.

After pooling the results of 27 trials involving 165,149 people, the meta - analysis reported that people are 21 percent less likely to suffer a serious vascular event such as a heart attack, stroke or bypass surgery after their cholesterol drops by the amount that might be expected after taking statins for a year than are similar people who do not take the pills.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

The trial, which began in 2001 and spanned 13 years, involved 24 people with a severe form of MS.. During that period, the positive results endured.

It typically takes many years to initiate such trials because of the stringent safety testing that must be done before testing in humans begins, but Reynolds said it may be possible to move faster as the therapy only involves modifying a patient's dietary intake and supplementing with a medium - chain triglyceride oil, both of which have no known side effects.

The trials lasted from 3 months to 6 years, and the children involved were followed up for various lengths of time after the trials had ended.

Kovatchev has racked up nearly 184,000 patient - hours, and counting, of clinical trials involving his version of an artificial pancreas — the time equivalent of one person wearing his device for more than 20 years.

However, Esther and the UNC coauthors, who were not involved in the clinical trial, said that a statistically significant increase in lung function is thought to lead to fewer CF - related flare - ups over the course of a year.

The new six - year study, «Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18 - month randomized clinical trial,» involved 54 adults and was led by Shaun Eack, Ph.D., M.S.W., Pitt's David E. Epperson Professor of Social Work and Psychiatry, and Nancy Minshew, M.D., Pitt professor of psychiatry and neurology.

Beer's team of prostate cancer researchers at OHSU's Knight Cancer Institute have been involved in, or led, clinical trials for three of the five new treatments developed for prostate cancer in recent years.

Analysis of data from nine randomised trials involving 6756 patients (1729 older than 80 years of age) showed that alteplase treatment significantly increased the odds of a good stroke outcome (no significant disability 3 - 6 months after stroke), with faster treatment offering the best chance of recovery.

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

This latest trial involved 320 children aged 4 to 11 years from 43 family practices in the UK who had recent histories of otitis media and effusion with confirmed fluid in one or both ears.

The trial involved 12 patients (6 women, 6 men) with moderate to severe depression (average length of illness was 17.8 years).

An earlier form of the vaccine was used in the DarDar Trial, a seven - year study in Tanzania sponsored by the U.S. National Institutes of Health involving patients with HIV infection who at birth had received BCG, the current tuberculosis vaccine.

The multicenter trial involving 100 patients showed that the addition of ipilimumab to nivolumab, which is currently FDA - approved for treatment of kidney cancer, leads to responses that can last beyond two years.

«They are the most rigorous double - blind placebo - controlled trials of a psychedelic drug in the past 50 years,» writes David Nutt, a pharmacologist at Imperial College London who was not involved in the work, in an editorial accompanying the papers.

In a Canadian trial involving 16 asthma patients, the procedure improved average air - flow rates in and out of the lungs, even when tested two years after treatment.

Later - phase clinical trials, which often take several years or more to conduct, often involve hundreds or thousands of patients.

Despite the studious modesty of that hope, a handful of clinical trials involving Tregs in transplantation and autoimmune diseases are already underway, and the coming years are poised to see a crop of promising clinical leads for cancer treatment.

The trial, a first in islet transplantation, is slated to begin in the fall of this year and will involve approximately 32 new transplants at up to eight clinical centers across North America and Europe.

To verify the effectiveness of aducanumab, a trial was set in place that involved 165 people receiving the drug and over the course of one year it was reported that the amyloid - beta levels in these people's brains had declined.

The challenge takes on even more urgency with recent developments, including a federal administration now more open to exploring the potential of stem cells, the recent FDA approval of a human trial involving embryonic stem cells, as well as the reported case of a young boy who developed a brain tumor four years after receiving a stem - cell treatment for a rare genetic disorder.

We also performed subgroup meta - analyses by type of prevention (primary v secondary: in this study, trials involving healthy populations or patients with any specific disease except for cardiovascular disease were classified as primary prevention trials, and trials involving patients with cardiovascular disease were classified as secondary prevention trials), type of supplement by quality and dose (each supplement, vitamins only, antioxidants only, or antioxidants excluding vitamins), type of outcome (cardiovascular death, angina, fatal or non-fatal myocardial infarction, stroke, or transient ischaemic attack), type of outcome in each supplement, type of study design (randomised, double blind, placebo controlled trial v open label, randomised controlled trial), methodological quality (high v low), duration of treatment (< 5 years v ≥ 5 years), funding source (pharmaceutical industry v independent organisation), provider of supplements (pharmaceutical industry v not pharmaceutical industry), type of control (placebo v no placebo), number of participants (≥ 10000 v < 10000), and supplements given singly or in combination with other vitamin or antioxidant supplements by quality.

A total of 27 trials involving 8000 prostate cancer patients showed that total androgen blockade improved the 5 - year survival rate by only 2 % and the 10 - year survival rate by only 0.7 %.

In this 8 - year trial, involving 41,186 particpants of the Black Women's Health Study, research data confirmed inverse associations between magnesium, calcium and major food sources in relation to type 2 diabetes that had already been reported in predominantly white populations.

The MCRI trial with children under the age of 3 years old involved one group of children wearing cotton for the first 6 weeks then changing to wool, and the other group starting with wool for the first 6 weeks then switching to cotton.

The movie is not only too long at 140 minutes, but it's overstuffed as well, so intent on covering every facet of the years - long conflict that Ross refuses to trim any fat, particularly a needless (and poorly acted) subplot involving the 1948 court trial of Knight's biracial great - grandson, who was prosecuted for marrying a white woman.

One part of the study is to include the first large randomised control trial of mindfulness training involving nearly 6,000 students and running for five years.

At the end of last year I visited Western Port Secondary College in Victoria — one of 21 government secondaries involved in the trial — to talk to assistant principal Hannah Lewis and student Harry Hainsworth.

The first trial of the system involved connecting every class in the school from Reception to Year 6.

A randomized trial involving 19 elementary schools (K — 5) was conducted to replicate and extend two previous experimental studies of the effects of a voluntary summer reading program that provided (a) books matched to students» reading levels and interests and (b) teacher scaffolding in the form of end - of - year comprehension lessons.

The trial of Accelerated Reader, funded by the EEF and led by the schools themselves, involved pupils at the start of year 7 who had not achieved Level 4 in their primary results for English.

Though only one year of data is available for analysis at this point, the study has involved a randomized field trial of over 400 teachers and administrators broken into test and control groups.