Sentences with phrase «years of uncertainty on»

The findings, published in The New England Journal of Medicine, mark the end of a five year trial and provide a definitive answer to 60 years of uncertainty on the use of progesterone treatment for women with unexplained recurrent losses.

The $ 177 million payout thus allowed Disney to avoid rolling the dice on a verdict and facing years of uncertainty on appeal.

Not exact matches

Political uncertainty is seen as one of the biggest drags on megadeals despite the performance of major stock markets throughout this year.

It said this would support its target of 5 percent per year on average output growth between 2016 and 2022, even though Total noted that the global environment remained volatile with persistent uncertainty around the evolution of global supply.

Switching on the Christmas lights in London's world famous Oxford Street is usually a jubilant time for U.K. retailers, but this year the holiday season is full of uncertainty.

Further, PDC urges you to carefully review and consider the cautionary statements and disclosures, specifically those under the heading «Risk Factors,» made in its Quarterly Report on Form 10 - Q, its Annual Report on Form 10 - K for the year ended December 31, 2016 (the «2016 Form 10 - K»), filed with the U.S. Securities and Exchange Commission («SEC») on February 28, 2017 and amended on May 1, 2018, and other filings with the SEC for further information on risks and uncertainties that could affect the Company's business, financial condition, results of operations, and prospects, which are incorporated by this reference as though fully set forth herein.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

Many pre-referendum forecasts, including those from major banks, argued the UK would enter a recession this year on the back of Brexit uncertainties.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

After years of economic expansion, the Turkish economy is set to continue struggling in 2017 on the back of growing terrorist acts, lack of structural reforms, falling tourism figures and increased political uncertainty.

Although the banks say the moves would be legal procedures that would have a minimum impact on their operations and jobs in Scotland, their warnings intensified concerns about an independent Scotland's ability to retain businesses — particularly during the months of financial uncertainty that would follow a vote to break the 307 - year union with England.

It added that «the effect on U.S. growth is estimated to be positive through 2020, cumulating to 1.2 percent through that year, with a range of uncertainty around this central scenario.»

Despite a heightened level of political uncertainty, a potential US - led trade war against China and fraught Brexit negotiations, companies have embarked on an unprecedented number of big acquisitions this year.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The Southeast Asian economy expanded 4.9 percent on - year over the April - June period amid uncertainties in global growth, persistent weakness in oil prices and the spreading of what is being called the country's worst - ever political crisis.

The deal removes a major source of legal and commercial uncertainty as the streaming company gears up for an initial public offering, expected on the New York Stock Exchange later this year or in early 2018.

«Balancing the budget for a fourth year in a row --- while other provinces grapple with debt, deficits, and economic uncertainty — is an accomplishment that gives the business community reassurance that B.C. is on the correct course,» said Iain Black, President and CEO of The Vancouver Board of Trade.

We caution you that these statements are not guarantees of future performance and are subject to numerous risks and uncertainties, including volatility in the economy and the credit markets, supply and demand changes for vacation ownership and residential products, competitive conditions; the availability of capital to finance growth, and other matters referred to under the heading «Risk Factors» contained in our Annual Report on 10 - K for the year ended December 30, 2011 filed with the U.S. Securities and Exchange Commission (the «SEC») and in subsequent SEC filings, any of which could cause actual results to differ materially from those expressed in or implied in this presentation.

Further demand increases and a lack of new hotel supply point to per - diem increases in 2016, but economic and geopolitical instability in Europe casts uncertainty on this year's currency exchange rates and business travel pricing.

An omnibus appropriations package, steel tariffs, regulatory work on the new tax law and general uncertainty about the nation's direction on policy and governing fueled K Street business during the first three months of this year.

IMI revenue up; warns on forex headwindsIMI PLC (IMI.LN) said Thursday that first - quarter performance continued the improved trend of 2017, albeit with uncertainty in some segments, and that current trading remains consistent with market expectations for the year.

This uncertainty seems to have led to increased levels of stress and anxiety, with 70 % of all US respondents reporting stress this year when thinking about retirement savings and investments, versus 67 % in 2015.5 Of those respondents who reported experiencing significant stress when thinking about their retirement savings, 65 % didn't know how much of their retirement savings they currently withdraw / spend or expect to withdraw / spend on an annual basis in retiremenof stress and anxiety, with 70 % of all US respondents reporting stress this year when thinking about retirement savings and investments, versus 67 % in 2015.5 Of those respondents who reported experiencing significant stress when thinking about their retirement savings, 65 % didn't know how much of their retirement savings they currently withdraw / spend or expect to withdraw / spend on an annual basis in retiremenof all US respondents reporting stress this year when thinking about retirement savings and investments, versus 67 % in 2015.5 Of those respondents who reported experiencing significant stress when thinking about their retirement savings, 65 % didn't know how much of their retirement savings they currently withdraw / spend or expect to withdraw / spend on an annual basis in retiremenOf those respondents who reported experiencing significant stress when thinking about their retirement savings, 65 % didn't know how much of their retirement savings they currently withdraw / spend or expect to withdraw / spend on an annual basis in retiremenof their retirement savings they currently withdraw / spend or expect to withdraw / spend on an annual basis in retirement.

This year has been one full of uncertainty and surprises on many fronts.

These risks and uncertainties include: fluctuations in U.S. and international economies and currencies, our ability to preserve, grow and leverage our brands, potential negative effects of material breaches of our information technology systems if any were to occur, costs associated with, and the successful execution of, the company's initiatives and plans, the acceptance of the company's products by our customers, the impact of competition, coffee, dairy and other raw material prices and availability, the effect of legal proceedings, and other risks detailed in the company filings with the Securities and Exchange Commission, including the «Risk Factors» section of Starbucks Annual Report on Form 10 - K for the fiscal year ended September 28, 2014.

Rather, it is a byproduct of the world's central banks, having intervened on vast scale to deal with the economic travails of the last several years, introducing uncertainty and even a little chaos as they start to contemplate how and when the era of easy money might end.

As was revealed in the just - released 2017 AFP Risk Survey, one of the top three risk factors having the greatest impact on organizations» earnings in the next three years was «U.S. political and regulatory uncertainty.»

We caution you that these statements are not guarantees of future performance and are subject to numerous risks and uncertainties, including volatility in the economy and the credit markets, supply and demand changes for vacation ownership and residential products, competitive conditions; the availability of capital to finance growth, and other matters referred to under the heading «Risk Factors» contained in the Information Statement filed as an exhibit to our Annual Report on Form 10 - K for the year ended December 30, 2011 filed with the U.S. Securities and Exchange Commission (the «SEC») and in subsequent SEC filings, any of which could cause actual results to differ materially from those expressed in or implied in this presentation.

«America's Navy still holds the title of best in the world, but our recent years of combat and physical uncertainty have eroded our warfighting advantage,» Admiral John Michael Richardson, chief of Naval operations, told the House Appropriations Committee on Defense in March.

The outlook is fraught with considerable uncertainty, Zentner cautions, particularly as it relies on an uncertain delivery of fiscal policy later this year.

Jeanne would thus have an ongoing source of cash to live on in her last years, and the lawyer would get an apartment cheaply, with no money down, in return for accepting the uncertainty as to when he would take possession.

Given the uncertainties of interpretation, it seems unwise to put too much emphasis on changes in employment over short periods; viewed over the past year, employment has been sluggish, and does not appear to have accelerated further since the initial pick - up in the September quarter 1996.

The increasingly strident rhetoric from both sides and absence of consensus among major powers on how to respond to North Korea's actions increased uncertainty, and by early September benchmark Treasury yields had fallen to their lowest level so far this year.

Party member Hong said that they had based the bill on research conducted between his office and the Korea International Trade Association (KITA) and reiterated that last years» government concerns could be addressed by more clarity: «The primary goal (of the legislation) is helping remove uncertainties facing blockchain - related businesses.»

Though a final deal on the United Kingdom's departure from the EU remains years away, the British pound has already experienced a significant adjustment, a stimulus which we believe should go a long way toward offsetting the potential negative effects of the uncertainty surrounding the country's relationship with Europe.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

U.S. - listed ETFs continued to rake in money in the latest week, even as political uncertainty in Washington fueled the largest stock market decline of the year on Wednesday.

It has been hard for me in this few years and I will do my best to hang on there until I reach my goal.I am not sure how long would it be for me to stay in the insurance business since there is many uncertainty about this kind of job.

An exception has been made this year after the wives were nominated in a letter noting that they have «bravely supported their husbands on the path to Christians unity: in the process they have surrendered financial security and family homes while having to support their families at a time of great stress and uncertainty.

a set of values, beliefs, and structure in a person's life in order to give them direction and a sense of right and wrong is fine, but organized religions are no more than large corporations, and like any large corporation are only focused on their bottom line... trying to control the public and extract as much money as they can from them by any means necessary... promoting fear, uncertainty, hate and a sense that they alone can offer salvation... for a price (although they are very cleaver about getting to this hidden and unspoken cost... after all these hundreds of years they have perfected their craft well!)

He notes that the subsequent years have brought disillusionment and deep uncertainty, but ends on the note that Christians once so inspired by the teachings of such as Dietrich Bonhoeffer will surely play a constructive role when the former East Germany finds its future.

It is inevitable that there will be confusion and uncertainty, perhaps for a number of years, before some agreement can be reached on what should replace that older morality.

In the last ten years I have moved increasingly toward experiential teaching (using self - awareness exercises, role playing of counseling methods, live demonstrations of growth groups, and so forth), which involves the students» own feelings, responses, and needs; asking the students to draw up their own «learning contract» based on what they want to get from a given course or workshop; expecting students to participate in the teaching by sharing in some systematic way the insights they have discovered to be meaningful; revealing my own struggles, uncertainties, and weaknesses; and asking the students to evaluate anonymously the course, including my teaching.

I agree with you that AW has done some astounding things for the club, but he has also made some reall balls ups and week in week out it seems he is not able to offer up a tactical plan B or utilise key players in key positions against the relevant sides we play, (not starting with Rosicky and Walcott on Saturday was one such instance) I realise that no team wins all their games and I know that we have been under the cosh for quiet a few years now, but what annoys me more than anything else is the lack of Visible ambition, we spent three weeks messing around with Beliek and only just managed to get Paulista who was an uncertainty due to a work visa.

One of the biggest concerns when betting on the Rookie of the Year odds is the uncertainty surrounding call - up dates for top prospects.

Gary Neville made very good point on why Wenger was given a 2 year deal to get rid of the «uncertainty» over his future which didn't really help the squad last year, but he also said, that Wenger might wan na leave on his own, but I don't believe Wenger would literally and metaphorically «wake up» and realise it's time to leave.

Further analysis of the impacts of policies on prices and bills, including analysis on households medium - sized businesses and large energy intensive users and a breakdown by individual policy, will be published later this year alongside the Annual Energy Statement and should provide more detail on the uncertainty surrounding the true cost of the Government's policies.

However, this year's higher education budget is a mixed bag for New Yorkers, leaving many unfinished items on the table and a trail of uncertainty for years to

Why do the Government not do one thing that would really help those centres and adopt a three - year funding cycle, as suggested by colleagues on the Opposition Benches, to try and put an end to the financial uncertainty that so many of those crisis centres still face?

Both houses of the Canadian federal government have passed a new law that when enacted will lift several years of uncertainty concerning the rights of American boaters and anglers on the St. Lawrence River, Lake Ontario, the Niagara River — in fact, on any border water of the two countries.

On Monday Lord Ashcroft ended years of uncertainty by confirming he is a non-domicile, meaning he does not pay income tax on money earned outside BritaiOn Monday Lord Ashcroft ended years of uncertainty by confirming he is a non-domicile, meaning he does not pay income tax on money earned outside Britaion money earned outside Britain.