This project — in collaboration with Texas A & M University — involves screening small molecules for specific effects on
the yeast cell cycle that correlate with longevity.
If it was, scientists could extrapolate a lot of what was known about
the yeast cell cycle into the still - mysterious human cell cycle.
Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in
the yeast cell cycle, cdc2, was also present in human cells.
Not exact matches
He spent his last year as a Lisbon student studying
cell -
cycle regulation in
yeast at the University of Manchester in the United Kingdom, with an Erasmus scholarship from the European Commission.
The role of DNA topology in holding sister chromatids together before anaphase was investigated by analyzing the structure of a small circular minichromosome in
cell cycle (cdc) mutants of the
yeast Saccharomyces cerevisiae.
She still does not know why he considered her at the time — «Maybe it was just my enthusiasm,» she wonders — but he nonetheless became her mentor as she studied the transcriptional activation of the
cell -
cycle regulated HO gene in the
yeast Saccharomyces cerevisiae.
While researching the life
cycle of baker's
yeast, Saccharomyces cerevisiae, Gottschling's team figured out a way to label
yeast so that they could spot genetic mistakes in daughter
cells.
The budding
yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the
cell cycle and signaling networks found in human biology having first been discovered in
yeast.
The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of
cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to
yeast.
In
yeast cells, the
cell division
cycle takes only 1.5 hours — meaning
yeast have a very rapid succession of generations.
Bruce Stillman DNA replication; chromatin assembly; biochemistry;
yeast genetics; cancer;
cell cycle
They found that like bacteria and budding
yeast, H. salinarum controls its size by adding a constant volume between two events in the
cell cycle.
Breeden, Prentice and Zhao, whose study appeared in the May 8 Proceedings of the National Academy of Sciences, compared their new algorithm to other methods used to analyze microarray experiments designed to identify
cell cycle genes in
yeast.
Swanton was stunned to learn how similar fundamental cellular processes were between humans and
yeast, and how
cell -
cycle regulation is related to cancer development.