Not exact matches
«We observed that the level of the Gcn4 protein was positively correlated with the
longevity of
yeast cells,» says Mihaela Zavolan, Professor of Computational and Systems Biology.
From these early studies, it became clear that insulin (a hormone secreted by the pancreas that signals
cells to absorb sugar) and its receptors are critical for
longevity in species from
yeast or fungi to humans.
This project — in collaboration with Texas A & M University — involves screening small molecules for specific effects on the
yeast cell cycle that correlate with
longevity.
Kennedy is interested in understanding why reduced gene expression in ribosomes enhances
longevity in
yeast and worms — ribosomes are tiny organelles that occur within the
cell and are involved in the production of proteins.
When resveratrol was applied to
yeast cells, their
longevity was extended by a huge 73 %.