Not exact matches
The team first used the tried - and - true method of growing
yeast in Petri dishes and painstakingly counting how many times an individual
yeast cell produced a
daughter cell.
The age - delaying action of caloric restriction may stunt the growth of
yeast cells so that the mother
cells and
daughter cells are easily flushed out of the chamber, Anderson speculates.
While researching the life cycle of baker's
yeast, Saccharomyces cerevisiae, Gottschling's team figured out a way to label
yeast so that they could spot genetic mistakes in
daughter cells.
To determine which strains yielded increased lifespan, the researchers counted
yeast cells, logging how many
daughter cells a mother produced before it stopped dividing.
Most importantly, this alteration could be passed down from mother to
daughter yeast cells.
William Ratcliff, a biologist at the Georgia Institute of Technology in Atlanta, and his collaborators have discovered a surprisingly simple route to multicellularity: a single mutation in
yeast that adheres the mother
cell to its
daughter to create a snowflake - like shape.
Polarization of diploid
daughter cells directed by spatial cues and GTP hydrolysis of Cdc42 in budding
yeast.
A typical
yeast cell replicates through budding of a
daughter cell and can undergo 20 - 30 such replication events before senescence.
To assess the breadth of such protein - based inheritance, the lab of Whitehead Member Susan Lindquist lab devised an unbiased screen that examines all proteins in
yeast for those capable of producing stable phenotypes that are passed from mother to
daughter cells for at least 100 generations.