One - third
of yeast genes have counterparts in the human genome, many of which are associated with diseases, such as cancer.
After years of studying
yeast genes in search of insights into how human DNA works, he was looking for a challenge.
Video of Adam, which can originate hypotheses
about yeast genes and their functions, design experiments to test the ideas and conduct the work.
Neva Parker is head of laboratory operations at White Labs, which helps brewers and wine - makers better understand
how yeast genes affect taste.
Fishel and Kolodner had been studying the bacteria and
yeast genes involved in the repair process that operates when base pairs slip out of alignment during replication, producing mismatches of bases.
They tested their system on a pair of yeast transcription factors and used the data to predict
which yeast genes the proteins would target, they report in this week's Science.
We have identified one such instance in a
bifunctional yeast gene where gene duplication enabled the two functions to become independently encoded and regulated and where most of the adaptive divergence between the two duplicates involved regulatory sequences.
It turns out that one
yeast gene in particular, called ATF1 for alcohol acetyl transferase, was responsible for the lion's share of those volatile chemicals.
Adam, a robot designed at Aberystwyth University in the UK, created 20 hypotheses
about yeast genes and illuminated a decades - old puzzle concerning which genes code for an enzyme.
Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in
how yeast genes are expressed — specifically how DNA gets transcribed into messenger RNA.
«First, we had to figure out much better methods to find human counterparts
of yeast genes, and then we had to arrange the humanized set of genes in a meaningful way,» explained Peng, now Assistant Professor of Computer Sciences at University of Illinois, Urbana - Champaign.
The researchers also modified some of the plant, rat and
yeast genes, as well as the medium in which the yeast proliferates, to help everything work better together.
We currently produce DNA microarrays representing the yeast, mouse, and human genomes (the yeast microarray has over 6000
yeast genes, the mouse microarray has over 15,000 mouse genes, and the two human microarrays have 1700 genes and over 19,000 genes).
When Fishel and Kolodner heard of the accumulation of mutations in cancer cells from patients with familial colon cancer, they suspected that the gene responsible would be similar to the bacterial and
yeast genes they had studied.
Those discoveries have allowed us to then understand how autophagy is important in mammalian systems, because
the yeast genes are very well conserved.»
«I think about 40 percent of
all yeast genes have a human counterpart or have a gene which is similar in function in humans,» says Marc Cockett, executive director of Functional Genomics at Bristol - Myers Squibb.
By inactivating
a yeast gene, the researchers stopped the production of a yeast steroid called ergosterol and instead allowed its precursors to accumulate.
In fact, many of the anti-aging pathways associated with
yeast genes are maintained all the way to humans.
The degree of DNA similarity didn't necessarily indicate whether a human gene could stand in for
a yeast gene, Marcotte and colleagues reveal online today in Science.
Because roughly two - thirds of
yeast genes are identical or strikingly similar to human genes, the study could help explain how proteins work in people.
They inserted DNA sequences into
the yeast genes so that the proteins the genes built were tagged with a string of peptides that bind with antibodies later added to the cell.
Gottschling now hopes that
this yeast gene will lead him to all the other cogs in the telomerase machinery.
Most people don't, but in order to unlock the mysteries of beers» beginnings, a group of scientists decided to sequence
its yeast genes.
The Berkeley researchers created a DNA package that included the mint and basil genes plus
some yeast genes that acted as «promoters» controlling the amount of each enzyme that would be produced during fermentation.
The role of this recycling and disposal system in human disease was not appreciated until Ohsumi and his colleagues» work in the 1990s revealed
the yeast genes that orchestrate the process.
in the 1990s revealed
the yeast genes that orchestrate the process.
Already, comparative genomic analysis of six species of yeast has prompted scientists to significantly revise their initial catalog of
yeast genes and to predict a new set of functional elements thought to play a role in regulating genome activity.