Fishel and Kolodner had been studying the bacteria and
yeast genes involved in the repair process that operates when base pairs slip out of alignment during replication, producing mismatches of bases.
Not exact matches
Although the whole drive to understand the molecular basis of beer production
involves modern tools that are used in biotechnology, such as real - time polymerase chain reaction (PCR),
gene chips, proteomics, mass spectrometers, and so forth, genetic manipulation is not acceptable in any form — not in any of the raw materials or the
yeast.
The only trouble was that the Nasmyth lab was devoted entirely to the study of the HO
gene (
involved in mating - type switching) in the budding
yeast Saccharomyces cerevisiae.
They found numerous
genes activated in the XYL regulon - controlled
yeast that upregulated pathways
involved in growth, such as cell wall maintenance, cell division, mitochondrial biogenesis and adenosine triphosphate (ATP) production.
Dr Nadeau added «Our results are even more surprising because the cortex
gene was previously thought to only be
involved in producing egg cells in female insects, and is very similar to a
gene that controls cell division in everything from
yeast to humans.»
Gottschling and his graduate student Miriam Singer devised a way to hunt for mutations in
genes that must somehow be
involved with telomere function in
yeast.
The process by which
yeast form spores
involves many more
genes and is more complex than researchers had expected, according to studies by scientists at the University of California, San Francisco -LRB-...
In addition to having connected research communities, Hieter and his lab have made many significant contributions to our understanding of chromosome biology, including the dissection of
yeast centromeres and the identification of
genes involved in genome stability.
Identify
genes and
gene products
involved in trafficking of proteins to the lysosome of Baker's
yeast; study their conservation in humans and their connection to human diseases such as Alzheimer's and cancer.
Leemor Joshua — Tor of the Howard Hughes Medical Institute and Cold Spring Harbor Laboratory wins award for her work in resolving the structures of proteins
involved in
gene silencing, DNA replication and
gene regulation in
yeast.
Kennedy is interested in understanding why reduced
gene expression in ribosomes enhances longevity in
yeast and worms — ribosomes are tiny organelles that occur within the cell and are
involved in the production of proteins.