Sentences with phrase «yeast model»

At the same time, Dr. Gitler's lab found that Dbr1 suppressed TDP - 43 toxicity in yeast models.

Eventually, using yeast models, the target of rapamycin (TOR) was identified, and the human counterpart was soon discovered — hence the name mammalian TOR, now given the catchy moniker — mTOR.

Using florescent tagging, they tracked the enzyme's presence on yeast models — which offer a number of commonalities in the processes of meiosis in humans.

The Noma laboratory has studied 3D chromosome organizations in the fission yeast model organism and the more complex human system.

Richard Weindruch of the University of Wisconsin, Madison, who is conducting calorie - restriction experiments in monkeys and other animals, applauds the new report but adds, «I think one needs to be very cautious about making dramatic leaps from the yeast model into mammals.»

Using a yeast model of Parkinson's disease, Lee and his team discovered two of the compounds prevented the AS protein from clumping, effectively allowing the cells to grow normally.

Researchers used a yeast model to better understand the consequences of the mutations.

«Putting the mutant proteins into the yeast model identified which defects were harmful and provided insight into the DDX3X protein function,» Partridge said.

Surprisingly, they discovered that a gene called ataxin - 2 harmed the yeast model of ALS, by directly interacting with an ALS - related protein called TDP - 43.

In a second paper published in the same issue of Science, Lindquist and Outeiro teamed up with Paul Muchowski, an assistant professor in pharmacology at the University of Washington, to explore other uses of Outeiro's yeast model.

Moreover, they are convinced that this yeast - human stem cell discovery platform could be applied to other neurodegenerative diseases for which yeast models have been developed.

He is also developing a yeast model of a rare disease called Lesch - Nyhan syndrome, in which individuals develop severe neurological and behavioral symptoms due to defects in a gene affecting purine metabolism.

The Noma laboratory seeks to determine evolutionarily conserved 3D genome - organizing mechanisms and their functions in the yeast model as well as in the human system, and also establish a clear mechanistic framework for understanding the molecular underpinnings for human cancers related to the disorganization of the cell nucleus.