Sentences with phrase «yeast prion protein»

The primary structure of the mammalian prion protein is completely different from that of the yeast prion protein.

The helpful yeast prion protein and the dangerous mammalian prion protein have virtually nothing in common.

Yeast can also carry prions, and the duo fused part of a yeast prion protein called Sup35 to a normal rat protein that controls the transcription of DNA into RNA.

Not exact matches

Study coauthor Susan Lindquist of the Whitehead Institute for Biomedical Research in Cambridge, Mass., and her colleagues devised a way to test plant proteins for prion power by swapping bits of them into yeast prions.

(stock image) Whitehead Institute scientists inserted the Arabidopsis thaliana protein Luminidependens (LD) into yeast to determine whether it has the traits of a prion.

To see if the candidates have the properties of prions, the scientists inserted the proteins into yeast, a model that the Lindquist lab has studied extensively.

Moreover, when the protein snippet was inserted into yeast, it could replace the functions of a known prion - forming yeast protein.

After consulting with Susan Lindquist, a yeast - prion expert at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, Kandel and Si fused the slug protein with the yeast - prion protein and found that the yeast - friendly CPEB acted like a prion, shifting shape and causing the proteins all around it to act identically in a very durable way.

Then Si noticed a molecular similarity in CPEB to a harmless prion protein found in yeast.

Not only that, but in the current issue of Molecular Cell, the Lindquist lab has identified a new yeast prion and shown that a segment of this protein also confers prionlike activity.

Meanwhile, Eisenberg and his group zoomed in on a yeast prion, discovering that it had interlocking teeth like a zipper, which contorted the proteins into a ropelike shape.

Previously, True and Whitehead Institute Director Susan Lindquist reported that a particular yeast protein called Sup35 somehow altered the metabolic properties — or phenotype — of the cell when it «misfolded» into a prion state.

Spontaneous Variants of the [RNQ +] Prion in Yeast Demonstrate the Extensive Conformational Diversity Possible with Prion Proteins.

Remarkably, the same yeast chaperone reacts with prion proteins from mammals.

Neither Hsp 104 or GroEL interacted with any of the dozens of other proteins tested, but each produced an effect on both yeast and mammalian prion proteins.

Although the yeast cells in these micrographs are expressing specific prion - like proteins (green, expressed protein label along top of micrographs), neither yeast containing prion - like proteins or the control exhibit the large protein masses expected in cells expressing prions.

Sondheimer focused his search on a handful of suspect proteins that possessed regions that looked a lot like the prion - determining regions of known yeast prions Sup35 and Ure2.

December 9, 1997 Discovery links new form of inheritance in yeast to «mad - cow» type diseases Researchers from the Howard Hughes Institute at the University of Chicago have discovered that a chaperone protein from yeast, which helps proteins to change their shapes, controls a new, protein - only form of inheritance, called a yeast prion.

Whitehead Institute scientists performed an unbiased screen in yeast cells that identifed dozens of prion - like proteins.

Researchers from the Howard Hughes Institute at the University of Chicago have discovered that a chaperone protein from yeast, which helps proteins to change their shapes, controls a new, protein - only form of inheritance, called a yeast prion.

Although the yeast sup35 protein and the mammalian prion protein are not at all related to each other — the yeast pose no risk to consumers of bread or beer — the researchers think that in - depth analysis of the yeast prion - like elements and other proteins that help them fold up may lead to new approaches to therapies for neurodegenerative diseases.

«The yeast and the mammalian prion proteins are genetically, structurally and functionally entirely different,» said Lindquist.

«We already know that two of the 6,200 proteins in yeast can be prions,» said Sondheimer.