The effect can work both ways —
young mouse stem cells lose potency in old blood.
Not exact matches
A small cluster of
stem cells in the brain seems to help
mice stay
young, and injecting extra
stem cells helps them live longer.
After receiving an injection of neural
stem cells from
young mice, however, they performed as well as healthy
mice did.
To their surprise, they found that when old and
young mice were joined, the muscle
stem cells in old
mice were revitalized.
Prins investigated the effect of BPA on human cells by implanting human prostate
stem cells taken from deceased
young - adult men into
mice.
Prins took human prostate
stem cells from deceased
young adult male organ donors and implanted the cells into
mice, where they formed human prostate tissue.
This rejuvenated the
stem cells in the bone marrow of the older
mice that replenish their blood, and led to a wave of studies comparing the blood of old and
young mice to try and identify the youth - giving substance.
In 2005, Rando and his colleagues published a study in Nature showing that
stem cells in several tissues of older
mice, including muscle, seemed to act
younger after continued exposure to
younger mice's blood.
In a study published June 27 in Cell Reports, a team led by Thomas Rando, MD, PhD, professor of neurology and neurological sciences and chief of the Veterans Affairs Palo Alto Health Care System's neurology service, has identified characteristic differences in «histone signatures» between
stem cells from the muscles of
young mice and old
mice.
Then an experiment in 2005 found that
young blood returned the liver and skeletal
stem cells of old
mice to a more youthful state, and work in 2012 discovered that
young blood can reverse heart decline in old
mice.
Now, new research from the laboratory of Vaijayanti P. Kale (National Centre for Cell Science, Pune, Maharashtra, India) has described a fascinating new approach to return lost functionality to aged
mouse HSCs: the transfer of microvesicles (MVs) containing positive regulators of autophagy derived from
young mesenchymal
stem cells (MSCs)[6].
Interestingly, we detected upregulation of p16 and p15 in Polycomb - null skin epithelial
stem cells in
young mice where it is normally detected only in aged animals.
Using
young and aged transgenic
mice and human - derived induced pluripotent
stem cells, she will examine the effect of Alzheimer's - related mutations on translation and protein expression.
By doing so, they found that the influx of certain immune cells, called macrophages, from the
young mouse helped resident
stem cells restore effective remyelination in the old
mouse's spinal cord.
With the excitement of a
young doctor fresh out of medical school, Morales» eyes light up when he observes the petri dishes that harvest «celulas madre,» or
stem cells, from
mice.
By studying the
stem cells in two types of tissue, namely skin, muscle, and in liver, in
young (three months old) and aged (18 to 22 months old)
mice every four hours, «we observed that the core components of the circadian clock had no changes in their rhythm with age».