Mehta J, Gordon LI, Tallman MS, et al., Does
younger donor age affect the outcome of reduced - intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?
Not exact matches
The charity serves as a platform through which individual
donors can support the education, health care, job training and personal development of
young people from birth to 24 years of
age.
Egg
donors are
young, healthy women between the
ages of 21 and 29 who live across the United States.
By enacting legislation that lowers that
age of
donors, New York is following the example of 47 other states in opens the state organ
donor registry to
younger adults in the hopes of increasing enrollment rates.
Indeed, this trend of less likelihood of live birth with
younger sperm
donor age might simply be explained by the fact that
younger men who donate sperm are less likely to have proven fertility themselves than older sperm
donors with proven fertility.»
A total of 70 DCD liver transplants were performed at the investigators» institution: 32 from
donors aged 55 years and
younger, 20 from
donors between 56 and 69 years, and 18 from
donors aged 70 years and older.
The local, in - person drives only accept
donors who are
younger than
age 45.
To study the effect of
ageing on the ability of CMV - specific CD8 (+) T cells to produce type 1 - and type 2 - cytokines, interferon - gamma - and IL -10-producing, CD8 (+) T cell responses in the presence of CMV peptide antigen were measured in CMV - seropositive old and
young donors.
Upon transfer of
aged donor CD4 T cells to
young hosts, there was significantly reduced expansion and germinal center (GC) differentiation of the antigen - specific B cell population after immunization.
The present study employed Ighb scid mice reconstituted with normal lymphocytes from
young (2 -3-mo-old) and
aged (20 -25-mo-old)
donors and immunized with a protein conjugate of the hapten (4 - hydroxy -3-nitrophenyl) acetyl (NP) to determine whether the molecular changes in antibody repertoire reflect senescence in the B cells or whether they are mediated by the
aging helper T lymphocytes.
When T cells were donated by
young mice, the anti-NP response in GC was dominated by the canonical V186.2 gene, even if the responder B cells came from
aged donors.
To examine the effect of
age on the cognate function of CD4 T cells, we have used a novel adoptive transfer model that allows us to compare identical numbers of antigen - specific naive T cells from
young and
aged TCR transgenic (Tg)
donors.
However, when the mice were reconstituted with T cells from
aged donors, the expression of the V186.2 gene by
young B cells was diminished and the response was dominated by the C1H4 gene, another member of the V186.2 / V3 family.
They offered customers over the
age of 35 injections of
young plasma — the liquid component of blood that blood banks usually store — from
donors ages 16 to 25.
In fact, using
younger donor eggs relieves most of the
age limitation,» he says.
This is why women who are menopausal can get pregnant with a
donor egg or with their own eggs preserved at a
younger age.