Sentences with phrase «zebrafish brain»

Molecular mechanisms of stem cell plasticity and regenerative neurogenesis in adult zebrafish brain

To identify the molecular mechanisms of neural stem cell plasticity in adult zebrafish brain after various types of tissue damage or physiological stimulations

Zebrafish brain regions, created within the Harvard ZBrain project and converted by us to 3D meshes, can be downloaded here.

Below is a short video of the current system showing the anatomically correct zebrafish brain regions in 3D.

But using a technique called calcium imaging, Aoki et al. were able to visualize for the first time the activity of the whole zebrafish brain during memory retrieval.

By observing the zebrafish brain activity upon presentation of the red LED they were able to visualize the process of remembering the learned avoidance behavior.

A novel drug screening platform for zebrafish brain tumors was then designed to identify drugs that could eliminate brain tumors without affecting development of the normal brain.

In the current study, the researchers showed that FGPs are present on the surface of the zebrafish brain and that these blood vessel - associated FGPs do not arise from the immune system, as had been previously thought, but from endothelial cells themselves.

This is an image of an adult zebrafish brain showing fluorescent granular perithelial cells (green) atop blood vessels (green).

«Zebrafish brain repair following concussion: New model enables study of animal's remarkable ability to regenerate injured brain tissue.»

Not exact matches

«BPA and BPS (substitute for BPA) affect embryonic brain development in zebrafish: Low levels of chemicals linked to hyperactivity.»

«We knew that the brain hat was a very high potential» among marchers, says Chris Pierret, a biologist at the Mayo Clinic in Rochester, but his group commissioned crocheted zebrafish hats, honoring one of their favorite disease research models.

Because zebrafish have a similar brain chemistry to humans, how they respond to certain drugs might indicate how the same drugs will affect people.

And drugs with similar fingerprints tended to tweak the same molecular pathways, which suggests zebrafish behaviour is a good indicator for how a drug will change chemistry in the human brain.

Engert, an associate professor in Harvard's Department of Molecular and Cellular Biology, studies vision and cognition by monitoring brain activity in zebrafish.

Unlike humans, zebrafish larvae are transparent, which allowed researchers to watch their brains as they slept.

It is, however, clear that cocaine is taken up rapidly and continuously by zebrafish larvae, which at this early stage have not yet a fully developed blood - brain barrier.

Glowing red, green and blue, the nerve fibers in this five - day - old zebrafish provide a map of early brain development.

However, the missing cells make Pro-melanin concentrating hormone (Pmch), a brain signal that was not perturbed in zebrafish.

Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal.

A simple and inexpensive zebrafish model of concussion, reported in eNeuro, reveals the genetic pathways underlying the animal's remarkable ability to regenerate injured brain tissue.

Zebrafish embryos have transparent brains, which allowed Peri and her team to track the microglia in real time under the microscope.

The results from McCammon's initial screen with zebrafish indicate that two genes in the 16p11.2 region could be key for brain development: fam57ba and doc2a.

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes — fam57ba and doc2a — in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity.

When zebrafish with the green fluorescing endothelial gene matured, the researchers observed green FGPs on the surface of the fish's brains — confirming that these cells arose from endothelial tissue.

National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.

In addition to seeing green lymphatic cells in the zebrafish embryos, the researchers noticed that green cells also covered the surface of the tiny fish's brains.

Boyden's team has also worked on the brains of fruit flies and zebrafish, while a collaborating group is applying expansion microscopy to human brains.

Researchers discovered a gene also found in humans helps zebrafish convert water motion into electrical impulses that are sent to the brain for perception.

By observing whole - brain activity in live zebrafish, researchers from the RIKEN Brain Science Institute have visualized for the first time how information stored as long - term memory in the cerebral cortex is processed to guide behavioral chobrain activity in live zebrafish, researchers from the RIKEN Brain Science Institute have visualized for the first time how information stored as long - term memory in the cerebral cortex is processed to guide behavioral choBrain Science Institute have visualized for the first time how information stored as long - term memory in the cerebral cortex is processed to guide behavioral choices.

Now, a study in the journal Brain describes what could be considered a direct «aquarium - to - bedside» approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease.

In order to understand this contradiction, the research group led by Raúl Estévez and Alejandro Barrallo compared genetically - modified zebrafish and mice models — in other words, knock - out organisms that, in this case, do not express the gene MLC1 — with the brain biopsy from an MLC patient.

Specifically, they tested new drugs in zebrafish, a small, tropical fish genetically similar to humans, whose brains can develop seizures in a manner similar to patients with epilepsy.

Working in zebrafish, for example, we will identify how small areas of the brain involved in initiating movements influence how the entire brain processes feedback from those movements.

In the Finkbeiner laboratory, Linsley uses time - lapse imaging of neurons in culture, within organotypic mouse brain slices, and within live zebrafish to uncover the mechanisms in neurodegeneration that lead to neuronal death.

To learn from zebrafish how to enable the adult brains to better cope with neurodegenerative disease and regenerate

Developing zebrafish models of complex phenotypes relevant to human brain disorders.

Caroline joined the Biophotonics group as a post doc in 2013 to implement confocal light - sheet microscopy for structural whole mouse brain imaging and then later functional calcium imaging in Zebrafish.

Because knockdown of Tuba in zebrafish affects cilia in a number of organs, including the brain, a variety of aberrant phenotypes were seen in the Tuba knockdown zebrafish model.

Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during brain development in zebrafish, and went on to show that the human versions of these RNAs can substitute for the zebrafish lincRNAs.

When the one of these lincRNA, called megamind, is reduced in zebrafish, the embryos have abnormally shaped heads and enlarged brain ventricles, as indicated by the arrow.

CAMBRIDGE, Mass. — Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during embryonic brain development in zebrafish.

Reduction of one of the lincRNAs, which they called cyrano, caused the zebrafish to have enlarged snouts, small heads and eyes, and short, curly tails, while the zebrafish lacking the lincRNA they called megamind had abnormally shaped heads and enlarged brain ventricles.

Whitehead Member Hazel Sive, who collaborated with Bartel and his lab members on the Cell paper, uses zebrafish to study brain development and genetic mutations linked to autism.

The integration of a novel high spatiotemporal resolution volume imaging technique and a fast 3D tracking system allows capturing whole brain neural activities in a freely behaving larval zebrafish.

Today he works on novel neural stimulation methods, whole - brain imaging of neural dynamics in larval zebrafish, and computational tools for the big data problems that arise from volumetric neural imaging datasets.