Sometimes referred to as the stem cells of
the zebrafish eye, Müller glia are the cells from which all other types of retinal cells are regenerated in the fish.
COVER A three - dimensional micrograph of computationally separated cells with their internal organelles, as captured by a movie of the developing
zebrafish eye.
In contrast to mammals, the elimination process is delayed as a result of the accumulation of cocaine in
zebrafish eyes: 50 % of the cocaine was eliminated after eight hours in clean water, and 30 % still remained after 48 hours.
In fact, both human and
zebrafish eyes contain Müller glia, an «inducible» stem cell type that gives zebrafish their remarkable regenerative abilities.
The art pieces captured chromosomes, cell division, plant hairs, close ups of insects,
zebrafish eyes, and much more.
Not exact matches
A study by Eawag and Zurich University researchers using a new imaging method has revealed that, surprisingly, cocaine accumulates in the
eyes of
zebrafish.
Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in
zebrafish, which resulted in abnormal facial cartilage, smaller
eyes and structural abnormalities of neurons involved in the development of reproductive organs.
Researchers at Johns Hopkins Medicine report evidence that
zebrafishes» natural ability to regenerate their
eyes» retinal tissue can be accelerated by controlling the fishes» immune systems.
«At the cellular level,
zebrafish and human
eyes are remarkably similar,» says Jeffrey Mumm, Ph.D., associate professor of ophthalmology at the Johns Hopkins University School of Medicine.
«Immune system found to control
eye tissue renewal in
zebrafish: Discovery suggests that strategies to regulate immune system cell reactivity to injury and cell loss might one day unlock and boost human tissue and cellular regeneration.»
The researchers hope that by harnessing the ability to improve regeneration in
zebrafish, they can better understand how to induce regeneration in human
eyes, which share many of the same mechanisms for controlling regenerative potential.
The study's lead investigator, Tom Reh, Ph.D., and his team at the UW Medicine in Seattle, looked to the
zebrafish for clues about how to encourage regeneration in the mouse
eye.
«Fish
eyes to help understand human inherited blindness: Discovery of a gene in
zebrafish that triggers congenital blindness could lead to a suitable cure for similar disease in humans..»
So desirable is the
zebrafish as a scientific model that the National Institutes of Health recently launched the NIH Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell a
zebrafish as a scientific model that the National Institutes of Health recently launched the NIH
Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell a
Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases,
eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell and taste.
The main focus is to understand how cell biology drives morphogenesis using vertebrate
eye formation as a model and
zebrafish as main experimental organism.
To do that we will activate the pathway in adults of this
zebrafish model using gene manipulation techniques, then test the health of
eye cells.
It captures our use of molecular tools with the
zebrafish model species to study the biology and development of the
eye lens.
Reduction of one of the lincRNAs, which they called cyrano, caused the
zebrafish to have enlarged snouts, small heads and
eyes, and short, curly tails, while the
zebrafish lacking the lincRNA they called megamind had abnormally shaped heads and enlarged brain ventricles.