Notch signaling coordinates cellular proliferation with differentiation during
zebrafish fin regeneration.
Franziska Knopf (Weidinger, TUD)-- «Bone regenerates via dedifferentiation of osteoblasts in
the zebrafish fin» (2011)
Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating
zebrafish fins.
Not exact matches
Salamanders and newts take this approach to heal and rebuild a severed limb, as do
zebrafish to mend clipped
fins.
When the scientists prevented the genes from working in
zebrafish, they failed to develop fingerlike projections called
fin rays — the fishes» «hands.»
In a paper published in the journal PLOS ONE, MDI Biological Laboratory scientists Benjamin L. King, Ph.D., and Voot P. Yin, Ph.D., identified these common genetic regulators in three regenerative species: the
zebrafish, a common aquarium fish originally from India; the axolotl, a salamander native to the lakes of Mexico; and the bichir, a ray -
finned fish from Africa.
Because these genes have the same function in
zebrafish, humans, and other tetrapods, it should help researchers further understand how our ancestors left the water and evolved limbs from
fins.
This time, the subject was the
zebrafish, and the robot was a free - swimming unit with the coloration, size, aspect ratio, and
fin shape of a fertile female member of the species.
Spiked structures on male
zebrafish pectoral
fins are important for mating but also produce a potent signaling inhibitor.
«We discovered that male
zebrafish have a very important set of structures on their pectoral
fins that they use for breeding and that these structures secrete a potent molecular inhibitor of a key signaling pathway to aid their cycles of regular replacement,» explains senior author Kenneth Poss of Duke University Medical Center.
Researchers from Joaquín Rodríguez León's laboratory set out to analyze the contribution of different ion fluxes in the cell membrane, either inwards or outwards, during regeneration in the
zebrafish caudal
fin.
The color pattern, aspect ratio, and shape of the caudal
fin of the mobile robotic fish used in our experiments matched that of a
zebrafish.
My laboratory uses the
zebrafish to elucidate the genetic circuitry that controls regeneration of two organ systems in response to injury: the adult heart and the caudal
fin appendage.
The effects of paclitaxel, a chemotherapy drug, can be seen on the cellular structures of the skin of a larval
zebrafish tail
fin.
Without Kdm6b.1,
zebrafish failed to regenerate amputated
fins, meaning removal of the «off» mark is a prerequisite for
fin regeneration.
In a report published on September 30 in Nature Genetics, Katsanis and his team used a small transparent fish,
zebrafish, to literally watch what happened if they chemically blocked the production of three proteins that are required for primary cilia function during the period when a fish egg develops into a grown up, fully -
finned fish.
The scientists found it shares a genetic mechanism with two other creatures that can regenerate tissue — the
zebrafish and a ray -
finned fish from Africa called the bichir.
The Washington researchers have discovered some of the genes that allow
zebrafish to regrow their tail
fins, which could one day help humans regrow damaged body parts.
If the fish's
fin gets bit off by, say, another hungry fish, the
zebrafish can grow a new tail in about a week, according to University of Washington researchers.