Sentences with phrase «zebrafish finds»

«Microbial dispersal impacts animal guts: Study with zebrafish finds that transmitted microbes will lead to similar microbiomes and a selection process for some microbes.»

Researchers have pursued alternative therapies for TB using a variety of animal models, including the zebrafish found in many pet stores and household aquariums.

«During heart regeneration in the zebrafish we found that cardiomyocytes displayed structural changes similar to those observed in hibernating cardiomyocytes,» he said, noting that those changes were actually necessary before the fish cardiomyoctes could start dividing.

Not exact matches

They found that the TAML - treated BPA water did not show estrogen activity or cause abnormalities in yeast and developing zebrafish embryos.

«We started out by imaging zebrafish, and ended up finding a factor that makes it possible to create lymphatic cells,» says Yaniv.

In 2005, when neurobiologist Herwig Baier of the University of California, San Francisco, was screening thousands of zebrafish for vision problems, he found one that seemed a bit «off.»

They next tested six randomly selected best - and worst - performing lipidoids in rats and found that the correlation between performance in rats and in zebrafish was 97 percent, suggesting that zebrafish are a good model for predicting drug - delivery success in mammals.

Studies found that a derivative excreted by juiced cattle reduces minnows» fertility, transforms female zebrafish into males, and induces other masculinizing effects.

The scientists hope their findings on cell migration in zebrafish will open up new perspectives for research on proteins that control metastasis and thus the malignancy of cancer.

The study found that zebrafish that failed to inherit specific genetic instructions from mom developed fatal defects earlier in development, even if the fish could make their own version of the gene.

The researchers found that maternal gdf3 is required for Ndr1 and Ndr2 to signal at the levels necessary to properly induce the formation of mesoderm and endoderm cells in early zebrafish embryos.

After following the fluctuations of these synapses over the course of a day, the team found that the zebrafish did indeed have lower overall synapse activity during sleep.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

«Now, through our new study, we show that lowering levels of a particular cohesin protein called Rad21 in embryonic zebrafish produces similar types of heart defects to those found in people with CdLS,» Associate Professor Horsfield says.

«Immune system found to control eye tissue renewal in zebrafish: Discovery suggests that strategies to regulate immune system cell reactivity to injury and cell loss might one day unlock and boost human tissue and cellular regeneration.»

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

Based on analyses of scales from highly relevant species for aquaculture such as common carp (Cyprinus carpio), gilthead sea bream (Sparus aurata), sea bass (Dicentrarchus labrax), Mozambique tilapia (Oreochromis mossambicus), Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss) and pike perch (Stizostedion lucioperca) as well as from fish commonly used in experimental studies such as zebrafish (Danio rerio), it was found that glucocorticoids, especially cortisol, incorporate in fish scales over time.

Zebrafish can find a way to compensate for a mutated gene, but artificial methods of inactivating the same gene are not so readily overcome, a new study suggests.

«We were very surprised to find, that for many categories of proteins, sharks share more similarities with humans than zebrafish,» Stanhope said.

Tobin also uses zebrafish to study bacteria closely related to those that cause tuberculosis, and findings from this model have been applied to understanding human disease.

In tests on zebrafish, flies and mice, scientists found that treating the disease with purified quercetin — which targets beta - catenin — led to a significant improvement in the health of nerve and muscle cells.

In the new study, conducted in zebrafish, researchers found that elimination of the α - synuclein protein protected the zebrafish against the ziram - induced loss of dopamine neurons.

In experiments with zebrafish embryos in which the expression of Abcb4 protein was suppressed, Luckenbach and his team found that the embryos were much more sensitive to toxic chemicals and that these substances were enriched to a greater extent in the embryo tissue.

The finding, in zebrafish and mice, may have implications for human diseases like multiple sclerosis, in which this insulation is lost.

GENE SCENE Zebrafish experiments that didn't go as planned may help researchers find genes that can fill in for others in a pinch.

Researchers discovered a gene also found in humans helps zebrafish convert water motion into electrical impulses that are sent to the brain for perception.

For the first time, it is now found by a study that various mechanisms of transcribing DNA into RNA exist during gene expression in the different development phases of zebrafish.

Surprisingly, the researchers found a similar bimodal 3 - dimensional chromatin architecture in the Hoxd gene region in zebrafish embryos.

A zebrafish model of Dravet syndrome, a severe form of pediatric epilepsy, may help scientists quickly find drugs for the devastating disease.

They found that while both types of ECM were effective in repairing damage to the mice hearts, the ECM obtained from the zebrafish hearts that were healing were even more potent in restoring heart function in the mice.

In another set of experiments, Thisse and his colleagues found that three molecules called BMP, Wnt8, and Nodal team up to create zebrafish tails.

Previous studies have found that mouse and zebrafish embryos do not develop properly in simulated microgravity.

The study, led by Yadong Wang, the William Kepler Whiteford Professor in Bioengineering in the Swanson School of Engineering and the principal investigator of the Biomaterials Foundry at Pitt, found that a single administration of extracellular matrices (ECM) from zebrafish hearts restored the function of the heart and regenerated adult mouse heart tissues after acute myocardial infarction.

«These findings show that tissue regeneration in African spiny mice is similar to that described for other vertebrate regenerators like salamanders and zebrafish, giving us a powerful framework to understand mammalian regeneration,» said Seifert.

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

Durdu, a PhD student in Darren Gilmour's lab at EMBL, found this behaviour in specific groups of cells in the zebrafish: the cells that will develop into the animal's «lateral line», a series of ear - like organs along the fish's flank that allow it to sense changes in water pressure.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.

As a tropical fish enthusiast, he chose the zebrafish, which is commonly found in pet shops and home aquaria.

These findings suggest that regenerating organisms such as zebrafish could use special molecular programs to modulate the plasticity of the neural stem cells and enable restoration of compromised neural tissues.

Sandra Rieger, an assistant professor of entity regeneration at MDI Biological Laboratory in Bar Harbor, found that an enzyme in the zebrafish's skin can prevent nerve endings from repairing themselves.

The findings, using zebrafish, may have implications for future treatments for the two conditions.

The researchers found that portions of the FTO gene were involved in switching on a promoter of IRX3, which encodes a transcription factor and is highly conserved in mice, zebrafish, and humans.

The findings are reported in two independent papers: the zebrafish study was published in the July 26 issue of Current Biology, the mouse study will be available in the early online edition of the Proceedings of the National Academy of Science this week.

Knowing that blastema formation is a key part of limb regeneration in animals with this capability as adults, researchers Benjamin L King and Voot P Yin looked at three regenerative species — the zebrafish, axolotl and the bichir — with the aim of finding out what genes control this event.

We have found that some of these variants are located in genome regions conserved down to the zebrafish, and surrounded by the same neighborhood of genes as in the human genome.

The topics include finding cancer cells, hand hygiene, zebrafish embryos and DNA code.

UT Health SA Newsroom: Surprising finding using zebrafish model explains how recurring cancer may resist treatment

Experiments on both larval zebrafish, a model for salmon, and actual coho salmon showed that toxic runoff can also damage hair - like sensors the fish use to find food, sense predators, and find their way in the current.

Ulitsky and Shkumatava, who report their findings in this week's issue of the journal Cell, tested the function of two of the 29 lincRNAs by knocking them down in zebrafish embryos.

The scientists found it shares a genetic mechanism with two other creatures that can regenerate tissue — the zebrafish and a ray - finned fish from Africa called the bichir.