Sentences with phrase «zebrafish for»

Lipschutz, who directs the zebrafish core at MUSC along with co-author Seok - Hyung Kim, Ph.D., is well aware of the advantages of the zebrafish for research — its genome is well characterized, it can be bred rapidly and inexpensively, and its transparent body enables easy visualization of aberrations under microscopy.

11:15 - 11:45 Stefan Örn and Gunnar Carlsson, Swedish University of Agricultural Sciences Zebrafish for environmental toxicity testing

The study's lead investigator, Tom Reh, Ph.D., and his team at the UW Medicine in Seattle, looked to the zebrafish for clues about how to encourage regeneration in the mouse eye.

«Given the limited number of successful therapies available today for repairing lost tissues, we need to look to animals like zebrafish for new clues about how to stimulate regeneration.»

Different types of studies use different stand - ins: Flies for genetics; zebrafish for early development; rats and mice and monkeys for cancer, neuroscience and more.

In 2005, when neurobiologist Herwig Baier of the University of California, San Francisco, was screening thousands of zebrafish for vision problems, he found one that seemed a bit «off.»

Not exact matches

«BPA and BPS (substitute for BPA) affect embryonic brain development in zebrafish: Low levels of chemicals linked to hyperactivity.»

In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for psychiatric disease after all.

Forthcoming workshops cover techniques as varied as «molecular and genetic tools for the analysis of medaka and zebrafish development» and «cryo - electron microscopy and 3 - D image reconstruction.»

They next tested six randomly selected best - and worst - performing lipidoids in rats and found that the correlation between performance in rats and in zebrafish was 97 percent, suggesting that zebrafish are a good model for predicting drug - delivery success in mammals.

Yanik and colleagues, who have extensive expertise with high - throughput screening in zebrafish and other small animals, have teamed up with Anderson et al., who are leading experts in RNA delivery, to create a new platform for rapidly screening biologics and methods to deliver them.

For the study, the researchers created a line of zebrafish with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune systFor the study, the researchers created a line of zebrafish with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune systfor development of an important component of the immune system.

In 2010, Yanik's team developed a technology for rapidly moving zebrafish larvae to an imaging platform, orienting them correctly, and imaging them.

«Microbial dispersal impacts animal guts: Study with zebrafish finds that transmitted microbes will lead to similar microbiomes and a selection process for some microbes.»

And drugs with similar fingerprints tended to tweak the same molecular pathways, which suggests zebrafish behaviour is a good indicator for how a drug will change chemistry in the human brain.

The scientists hope their findings on cell migration in zebrafish will open up new perspectives for research on proteins that control metastasis and thus the malignancy of cancer.

Would happy lab animals — rats, mice, even zebrafish — make for better experiments?

The researchers found that maternal gdf3 is required for Ndr1 and Ndr2 to signal at the levels necessary to properly induce the formation of mesoderm and endoderm cells in early zebrafish embryos.

Using embryos of zebrafish, which was selected for its rapid development and optical transparency, they could show that the mechanical properties of the tissue change along the body axis, facilitating the extension of the body at its posterior end.

«Zebrafish could have a unique niche [in cancer treatment],» says Leonard Zon of Harvard Medical School in Boston, who has used the fish for more than a decade to study how cancer develops.

This week, Fior, who is at the Champalimaud Centre for the Unknown in Lisbon, and her colleagues reported growing implanted human tumor cells in zebrafish larvae.

Cocaine distribution in five - day - old zebrafish larvae exposed to 50 µM cocaine for eight hours.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

By chemically removing the gut microbiome in zebrafish in the lab and then repopulating the gut with two to three bacterial species, University of Oregon biologist Karen Guillemin has shown that certain microbes are especially skilled at suppressing the host immune system and preventing inflammation — a discovery she thinks may have implications for human health.

Companies in the region that have announced staff cuts include Oxford - based Summit Corporation, a zebrafish genomics specialist; Alizyme of Cambridge, which is developing treatments for gastrointestinal diseases; and Silence Therapeutics of London, an siRNA company.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

She commented: «Our previous research to validate zebrafish as a model for epilepsy put us in a good position to be able to help the EuroEPINOMICS consortium investigate the function of CHD2.

«Although zebrafish look quite different from humans, they share an astonishing 70 percent of their genetic material with humans, including genes important for the formation of new heart muscle,» Yin said.

If you actually read the paper that launched a thousand offbeat tidbits, by one Emmanuel Mignot of Stanford University, you discover that those «mutant» zebrafish with the defective genes were engineered to be mutants, in bulk, purely for the purpose of research.

The zebrafish research was led by Camila Esguerra of the Laboratory for Molecular Biodiscovery of University of Leuven (Leuven, Belgium).

Which leaves only those poor insomniac zebrafish, for whom I bear tidings that should have church bells ringing from one end of Zebrafish Land to the other immediately upon their receipt: Apparently, fish don't just get zebrafish, for whom I bear tidings that should have church bells ringing from one end of Zebrafish Land to the other immediately upon their receipt: Apparently, fish don't just get Zebrafish Land to the other immediately upon their receipt: Apparently, fish don't just get insomnia.

The zebrafish larva is an ideal model to study genes involved in epilepsy, and the methods necessary for such studies are now well - established in our laboratory.

In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy.

Instead of mice, it produces fluorescent zebrafish, which are easier for the undergraduate - staffed lab to handle, in part because they go from fertilization to free - swimming fish in a matter of days.

The protein itself has been known to researchers for some time as a result of research on zebrafish, where it plays an important role in the healing process following damage to the spinal cord.

In the study, the researchers used zebrafish lines that had been selected to be bolder by breeding fish that stayed still for a maximum of 50 seconds after being introduced into new surroundings, while shy fish — those that stayed still for more than 3 minutes when dropped into a new area — were bred to create a shy line.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

The results from McCammon's initial screen with zebrafish indicate that two genes in the 16p11.2 region could be key for brain development: fam57ba and doc2a.

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes — fam57ba and doc2a — in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity.

For this reason, the zebrafish is now used as a model organism by scientists around the globe.

The researchers hope that by harnessing the ability to improve regeneration in zebrafish, they can better understand how to induce regeneration in human eyes, which share many of the same mechanisms for controlling regenerative potential.

Some mouse and zebrafish genes remain active for up to four days after the animals die, scientists reported in 2017 in Open Biology.

Based on analyses of scales from highly relevant species for aquaculture such as common carp (Cyprinus carpio), gilthead sea bream (Sparus aurata), sea bass (Dicentrarchus labrax), Mozambique tilapia (Oreochromis mossambicus), Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss) and pike perch (Stizostedion lucioperca) as well as from fish commonly used in experimental studies such as zebrafish (Danio rerio), it was found that glucocorticoids, especially cortisol, incorporate in fish scales over time.

«Right now success rates for grant applications are about 23 percent, which is not bad in an international context,» says Joan Heath, a zebrafish researcher at the Parkville Branch of the Ludwig Institute for Cancer Research in Melbourne, Australia.

Zebrafish can find a way to compensate for a mutated gene, but artificial methods of inactivating the same gene are not so readily overcome, a new study suggests.

A freshwater zebrafish costs less than two bucks at the pet store, but it can do something priceless: Its spinal cord can heal completely after being severed, a paralyzing and often fatal injury for humans.

Using live imaging in zebrafish to track oligodendrocytes in real time, researchers reporting in the June 24 issue of the Cell Press journal Developmental Cell discovered that individual oligodendrocytes coat neurons with myelin for only five hours after they are born.

«We were very surprised to find, that for many categories of proteins, sharks share more similarities with humans than zebrafish,» Stanhope said.

Zebrafish with very weak muscles helped scientists decode the elusive genetic mutation responsible for Native American myopathy, a rare, hereditary muscle disease that afflicts Native Americans in North Carolina.

Scientists established the importance of Stac3 for muscle function in zebrafish by studying the small fish physiologically and genetically.