Sentences with phrase «zebrafish genome»

As with other model organisms, the fully sequenced zebrafish genome has acted as an invaluable reference tool for scientists.

Scientists at the Wellcome Trust Sanger Institute therefore set about sequencing the zebrafish genome in February 2001.

Sequencing the zebrafish genome provided evidence of more than 26,000 protein - coding genes, the largest set of any vertebrate sequenced so far.

The community got together to initiate the sequencing of the whole zebrafish genome, which began in 2001 at the Wellcome Trust Sanger Institute in Cambridge.

This information would then be added into the core Ensembl gene - set (the reference zebrafish genome used by researchers around the world) in such a way as to increase the quantity and quality of the gene - set without adding artifacts or pseudogenes.

Like the human genome, the zebrafish genome has two copies of each gene, and scientists can remove the function of multiple genes to produce phenotypes that are reminiscent of human symptoms.

Not exact matches

«We'll continue to investigate mechanisms by which neural tissue bridges to repair the spinal cord in zebrafish, taking advantage of the power of genome editing to examine other factors,» said Poss.

Furthermore, a comparison of genomes between ten species of fish, including zebrafish and pufferfish, and humans revealed that fish lack the genetic information to make Nogo - A or a similar inhibitor.

COURTESY SHENDURE AND SCHIER LABS CRISPR FOR FATE - MAPPING Researcher: Jay Shendure, Professor, Department of Genome Sciences, University of Washington Project: In collaboration with Alexander Schier's lab at Harvard University, Shendure's group came up with a new way to trace cell lineages in cell culture and in whole organisms — in this case, developing zebrafish.

The results of our efforts were published recently in a paper entitled Incorporating RNA - seq data into the Zebrafish Ensembl Gene Build in Genome Research.

In their study, to be published in the online edition of the Proceedings of the National Academy of Sciences during the week of Jan. 26 - 30, researchers from Fukui Prefectural University in Obama, Japan, and the National Human Genome Research Institute (NHGRI), which is part of the National Institutes of Health (NIH), describe the innovative techniques they used to produce genetically modified zebrafish using sperm cells grown under laboratory, or «in vitro,» conditions.

Birgit Kagermeier - Schenk (Weidinger, TUD)-- «Genome - wide analysis of Wnt / beta - catenin target genes in zebrafish embryogenesis and characterization of a novel modifier of Wnt signaling pathways» (2010)

A systematic genome - wide analysis of zebrafish protein - coding gene function.

The database also contains annotation from regions, not just whole genomes, and displays multiple species annotation (human, mouse, dog and zebrafish) for comparative analysis.

The zebrafish facility at SciLifeLab has participated in the development of a high - throughput gene targeting method in zebrafish, presented in the July issue of Genome Research.

SPECIES COMPARISON: This circular genome map shows shared genetic material between humans (outer ring) and (from inner ring outwards) chimpanzee, mouse, rat, dog, chicken, and zebrafish chromosomes.

We have found that some of these variants are located in genome regions conserved down to the zebrafish, and surrounded by the same neighborhood of genes as in the human genome.

The platform now proposes techniques to generate zebrafish lines via genome editing and KO (Knock - Out) models.

Lipschutz, who directs the zebrafish core at MUSC along with co-author Seok - Hyung Kim, Ph.D., is well aware of the advantages of the zebrafish for research — its genome is well characterized, it can be bred rapidly and inexpensively, and its transparent body enables easy visualization of aberrations under microscopy.

During his PhD he worked on three main projects: digital scanned laser light sheet fluorescence microscopy (with Dr. Ernst Stelzer), the in toto reconstruction of zebrafish embryogenesis (with Dr. Jochen Wittbrodt), and the computational analysis of the evolution of the yeast genome architecture (with Dr. Michael Knop).

Their genome has been fully sequenced, and at least 70 % of human genes have a zebrafish equivalent.

We integrate functional genomic datasets with up - to - date gene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematode.

The SciLifeLab zebrafish facility has participated in the development of the method at the National Human Genome Research Institute (NHGRI), a part of the National Institutes of Health, USA.

A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.