Sentences with phrase «zebrafish larvae»

In the supplementary material, Video S1 shows clearly a continuous blood flow along intersegmentals vessel of control zebrafish larvae.

Zebrafish larvae exposed to runoff from a June 2014 storm developed one - third fewer hair cells in their head and trunk.

Zebrafish larvae transplanted with patients» tumors respond as their human donors do to chemotherapy.

Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae.

13:55 - 14:15 Roger Olsson, Lund University, Dept. of Experimental Medical Science Using zebrafish larvae in phenotypic CNS drug discovery and toxicology evaluation

Zebrafish larvae readily absorb compounds from the surrounding water, which is a great advantage when it comes to determining the effects of certain drugs or other substances.

Zebrafish larvae (96 hpf) were loaded into a 96 - well plate and run through a light - dark test in the observation chamber.

In order to test whether isradipine, minocycline, and rasagiline could protect or restore locomotor functioning after treatment with 6 - OHDA (a well - known model for Parkinson's), the zebrafish larvae were tested using DanioVision.

To better test the effects on locomotor activity in response to certain compounds, zebrafish larvae can be loaded into multi-well plates.

In zebrafish studies, the light - sensitive receptor protein halorhodopsin (NpHR) has successfully been used to inhibit swimming behavior in zebrafish larvae (Arrenberg, et al., 2009).

DanioScope is a software program that does exactly that, offering a very straight - forward tool to accurately and efficiently assess the heart rates of multiple zebrafish larvae simultaneously.

The complete system designed for experiments with zebrafish larvae.

We want you to have software that fits the bill for all of these, from straight - forward protocols such as open field or Morris water maze testing, to high - throughput testing, such as zebrafish larvae activity monitoring in 96 - well plates.

DanioVision is a complete system designed for exactly these types of experiments with zebrafish larvae, and is often used in studies related to drug development, safety pharmacology, behavioral genetics, and circadian rhythmicity.

Combining the advantage of zebrafish larvae being transparent with the latest developments in video analysis technologies, results in a much more efficient and less invasive method.

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

So they injected the organism into microscopic zebrafish larvae, which have clear bodies, and watched the infection take hold.

«In order to be able to research more closely what effect PSENEN has, we, in collaboration with Prof. Odermatt, deactivated the gene in some zebrafish larvae and then compared these with normal larvae under the microscope,» explains Damian Ralser.

Zebrafish larvae and fluorescently marked immune cells allow researchers to track immune system activity in a model of retinal degeneration.

In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humans).

Cocaine distribution in five - day - old zebrafish larvae exposed to 50 µM cocaine for eight hours.

This week, Fior, who is at the Champalimaud Centre for the Unknown in Lisbon, and her colleagues reported growing implanted human tumor cells in zebrafish larvae.

It is, however, clear that cocaine is taken up rapidly and continuously by zebrafish larvae, which at this early stage have not yet a fully developed blood - brain barrier.

Zebrafish larvae a few days old are frequently used in toxicology tests — e.g. to study the behavioural effects of drugs — in order to avoid experiments in mammals.

Unlike humans, zebrafish larvae are transparent, which allowed researchers to watch their brains as they slept.

Meanwhile, Alexander Schier at the University of Harvard and colleagues measured how various drugs changed the sleep - wake cycles of zebrafish larvae (Science, DOI: 10.1126 / science.1183090).

In 2010, Yanik's team developed a technology for rapidly moving zebrafish larvae to an imaging platform, orienting them correctly, and imaging them.

The zebrafish larva is an ideal model to study genes involved in epilepsy, and the methods necessary for such studies are now well - established in our laboratory.

A zebrafish larva is infected with Cryptococcal meningitis and photographed under a microscope.

The upper image is a three - day - old zebrafish larva showing activation of green fluorescent protein expression in the liver (arrow) following exposure to an estrogenic compound.

Blood vessels of a zebrafish larva: if the gene EGFL7 is lacking, the blood vessels (stained green) are not formed correctly.

The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva to visualize lipid uptake and processing in real time.

Zebrafish larva implanted with cancer patient's tumor (red) RITA FIOR / CHAMPALIMAUD CENTRE FOR THE UNKNOWNSee R. Fior et al., «Single - cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts,» PNAS, doi: 10.1073 / pnas.1618389114, 2017

Not exact matches

Baier's experiments used adult fish, whereas most zebrafish screens use larvae.

That allows her to image the cells of awake, moving creatures, such as the flashing neurons of crawling fly larvae or the beating hearts of twitching zebrafish, without the problem of blurring when the animal moves.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

Plus, rumors abound over a new gravitational wave signal, zebrafish can be trained to crave — and self - administer — opioids, astronomers discover the source of a nova witnessed in the 15th century, and burying beetles concoct a «cocktail» of microbe - laced slime to keep their larvae healthy.

A group of researchers recently tried to settle this debate by studying the larvae of a common see - through aquarium pet, the zebrafish.

But the larvae of zebrafish go one further.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

During the course, students collect zebrafish embryos and watch them develop from single cells to swimming larvae complete with beating hearts and distinct pigmentation.

Cardiac Edema and Cranial Injuries Laboratory experiments involving zebrafish have previously shown that oil pollution causes the larvae to develop cardiac edema.

We use the zebrafish model to study β - cell development due to the small size and optical transparency of its embryos / larvae, as well as the ease of the genetic and chemical - genetic manipulations, including the ability to conduct large - scale small molecule screens.

Developmental toxicity of CdTe QDs in zebrafish embryos and larvae.

Two stereomicroscopes, an Olympus FVX10, and a Zeiss V12 Discovery are available for transmitted light and epifluorescence imaging of C. elegans, zebrafish embryos and larvae, and other larger species and specimens.