Sentences with phrase «zebrafish model system»

Toxicology and compound testing The zebrafish model system is ideal for testing biological effects on tissue homeostasis and organism development of substances and pollutants.

Here, the authors leveraged a zebrafish model system to examine the role of that enhancer during development.

The researchers will use their zebrafish model system to search for new therapeutics that could block drug - seeking behavior.

According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.

Not exact matches

More recently, Godinho Ferreira, who now employs three Ph.D. students and four postdocs, has been working to establish Zebrafish as a new model system to try and understand the role of telomeres in aging and the role of telomere - elongation enzymes in cancer.

Zebrafish larvae and fluorescently marked immune cells allow researchers to track immune system activity in a model of retinal degeneration.

«Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities,» Perfect said.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

Monk and her team study zebrafish because they are excellent models of the vertebrate nervous system.

«Organ development, especially the liver, is highly conserved among vertebrates — including zebrafish — and the mutations we create in zebrafish alter embryogenesis in a manner consistent with humans, making it an ideal model system to study diseases such as Alagille syndrome.»

Using zebrafish as a model system, the researchers exposed the fish embryos to seven different types of TAML activators.

Tobin, who helped to develop the zebrafish as a model of TB, decided to use the system to study the blood vessels associated with granulomas.

CELPHEDIA WP1 workgroup gathers experts using CRISPR / Cas9 system in various animal models including mouse, rat, zebrafish and drosophila.

So desirable is the zebrafish as a scientific model that the National Institutes of Health recently launched the NIH Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell azebrafish as a scientific model that the National Institutes of Health recently launched the NIH Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell aZebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell and taste.

The CCP is engaged in numerous multidisciplinary projects in other model systems (e.g. fly, zebrafish, yeast) that aim to determine how complex molecular circuits function and evolve in response to genetic and environmental changes, cellular differentiation, evolution and disease.

The zebrafish is now a well - established model system whereas zebrafish research was mere small fry as recently as the 1990s.

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

Developing zebrafish methodology to model genetic and environmental modifiers of the vertebrate stress response system (SRS).

On the other hand, the present research work shows a confirmatory evidence of the potential of kahweol to inhibit in vivo angiogenesis, by using another completely independent model system, namely, that of genetically modified zebrafish.

For example, the zebrafish, a common aquarium specimen, possesses the remarkable ability to rapidly replace damaged and lost body parts including limbs, heart, and nervous system, making it an ideal model for defining the genetic mechanisms of regeneration and healing and for identifying drug candidates for use in regenerative medicine.

To demonstrate Amrose functionality in an established higher model system, Amrose v0 — v4 variants were cloned into the pCS2 + vector system to synthesize mRNA by in vitro transcription, which was used for injection into one - cell stage zebrafish embryos.

His group uses the zebrafish (Danio rerio) as a model system to study various processes.

121/4: 00 Cbx3 and its role in craniofacial development: Zebrafish as a model system for testing dysmorphology candidate genes.