Sentences with phrase «zebrafish models»
The phrase "zebrafish models" refers to the use of small fish called zebrafish in scientific studies to understand different processes or diseases in humans. Researchers use these fish because their biology is similar to ours, making them a useful tool to learn about our own bodies. Full definition
Developing zebrafish models of complex phenotypes relevant to human brain disorders.
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Genetic modification in zebrafish models is cheap and easy, so authors point out that future research on these animal models will contribute to understand the molecular relationship that exists between the proteins involved in the physiopathology of megalencephalic leukoencephalopathy.
UT Health SA Newsroom: Surprising finding using zebrafish model explains how recurring cancer may resist treatment
Developing innovative zebrafish models for drug abuse research.
Depletion of dynamin - binding protein or Tuba, a guanine nucleotide exchange factor, disrupted renal ciliogenesis in cell culture and led to abnormal kidney morphology in a Tuba knockdown zebrafish model of PKD.
A simple and inexpensive zebrafish model of concussion, reported in eNeuro, reveals the genetic pathways underlying the animal's remarkable ability to regenerate injured brain tissue.
«Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial: Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»
«Clinical phenotype similarity in megalencephalic leukoencephalopathy patients explained by zebrafish model study.»
A new study of the University of Barcelona, published in the journal Human Molecular Genetics, first describes a phenotype of this human disease through the study of genetically - modified zebrafish models.
Now, a study in the journal Brain describes what could be considered a direct «aquarium - to - bedside» approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease.
Trainings to generate genetically modified models in specific organisms will be provided on different sites according the speciality: zebrafish model at AMAGEN (Gif - s - Yvette), rat model at the TRIP (Nantes) and mouse model at Anexplo (Toulouse).
In addition to research on rhabdomyosarcoma, the Ignatius laboratory has also generated new syngeneic zebrafish models of aggressive Malignant Nerve Sheath Tumors and hemangiosarcomas for which there are no effective treatments.
Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).
Working in collaboration with Dr Eric Glasgow of the Georgetown University Medical Center in Washington D.C., the two teams used zebrafish models to study the consequences of chromosome 6 deletion and showed that the deletion has an effect on specific cells in the hypothalamus that produce a hormone called oxytocin.
Because knockdown of Tuba in zebrafish affects cilia in a number of organs, including the brain, a variety of aberrant phenotypes were seen in the Tuba knockdown zebrafish model.
Through studying these genes, the researchers discovered Stasimon, a novel gene critical for motor circuit activity in fly and zebrafish models of SMA.
The researchers found that several lipidoids that had not performed well in cultured cells did deliver RNA efficiently in the zebrafish model.
Looking forward, our zebrafish models of pharmacoresisant epilepsy are well - suited for large - scale pharmacological screens to find new anti-epileptic drugs.»
And despite the utility of the zebrafish model for sussing out how microglia work, drug researchers are going to have to look elsewhere, says Verkhratsky.»
In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy.
To test whether fatty acid levels in the bloodstream was a cause or a consequence of disease, the researchers turned to a zebrafish model of Crohn's disease that had been developed by Stefan Oehlers, a post-doctoral fellow in David Tobin's group at Duke.
«Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities,» Perfect said.
Using a zebrafish model, researchers were able to reverse the defects caused by the UBQLN4 gene variant by inhibiting the beta catenin signaling pathway with the drug quercetin.
According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.
The next steps for the research group are to use what they have learned from this zebrafish model of gut inflammation to design better probiotics to treat intestinal inflammation.
«The zebrafish model allowed us to control those variables and see how bacterial strains tracked with inflammation.
The researchers will use their zebrafish model system to search for new therapeutics that could block drug - seeking behavior.
Bossé explained that the zebrafish model is scalable and could be used to rapidly screen through thousands of compounds.
A zebrafish model of Dravet syndrome, a severe form of pediatric epilepsy, may help scientists quickly find drugs for the devastating disease.
Endowed Chair in Neuroscience Research and professor of neurological surgery at the University of California, San Francisco (UCSF), postdoctoral fellow Aliesha Griffin, Ph.D., and colleagues used a zebrafish model of Dravet syndrome to test the drug lorcaserin and found that it suppressed seizure activity in the fish.
I am interested in applying fluorescence lifetime imaging microscopy (FLIM) to study the metabolic activity during immune response to pancreatic cancer in a zebrafish model.
Here, the authors leveraged a zebrafish model system to examine the role of that enhancer during development.
With its zebrafish model, Saffitz's team tested 5,000 compounds in about six months.
In their zebrafish model, the barcode contains 10 20 - base - pair sequences targeted by Cas9 endonuclease, with each of the sequences matching a specific single guide RNA.
At the Erasmus Medical Center in Rotterdam, the Netherlands, researchers have investigated this movement disorder using a PARK15 (an atypical early - onset parkinsonism) zebrafish model and DanioVision.
We use the zebrafish model to study β - cell development due to the small size and optical transparency of its embryos / larvae, as well as the ease of the genetic and chemical - genetic manipulations, including the ability to conduct large - scale small molecule screens.
Toxicology and compound testing The zebrafish model system is ideal for testing biological effects on tissue homeostasis and organism development of substances and pollutants.
A Zebrafish Model of Wet Macular Degeneration Daniel Chao, MD, PhD University of California, San Diego (La Jolla, CA)
Genetic tools and applications The tools for genetic manipulation in the zebrafish model system develops fast.
To do that we will activate the pathway in adults of this zebrafish model using gene manipulation techniques, then test the health of eye cells.
It captures our use of molecular tools with the zebrafish model species to study the biology and development of the eye lens.
C) Angiogenesis assay in the zebrafish model.
In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesis.
Building bridges with zebrafish: highlights of the «Zebrafish Models in Translational Medicine Meeting».
In a zebrafish model of cryptococcal disease, a decrease in ERK5 activity led to reduced dissemination of infection by an increase in vomocytosis.
Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.
We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans.
The E16G appears to be a significant variation from variant 1 displaying an enhanced brightness in context of the Zebrafish model where transcript stability, post-translational eukaryotic context and / or lower temperature may play a role.