Sentences with phrase «zebrafish models for»

Developing innovative zebrafish models for drug abuse research.

In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy.

Not exact matches

In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for psychiatric disease after all.

They next tested six randomly selected best - and worst - performing lipidoids in rats and found that the correlation between performance in rats and in zebrafish was 97 percent, suggesting that zebrafish are a good model for predicting drug - delivery success in mammals.

She commented: «Our previous research to validate zebrafish as a model for epilepsy put us in a good position to be able to help the EuroEPINOMICS consortium investigate the function of CHD2.

The zebrafish larva is an ideal model to study genes involved in epilepsy, and the methods necessary for such studies are now well - established in our laboratory.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

For this reason, the zebrafish is now used as a model organism by scientists around the globe.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

Zebrafish have emerged as an important vertebrate model for cardiovascular research for a number of reasons, including the ability to regenerate its heart if damaged, and because the transparency of the embryos allows easy observation of internal processes like blood vessel development.

According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.

The next steps for the research group are to use what they have learned from this zebrafish model of gut inflammation to design better probiotics to treat intestinal inflammation.

The researchers will use their zebrafish model system to search for new therapeutics that could block drug - seeking behavior.

Using genetic models in a variety of organisms — yeast, nematodes, fruit flies, zebrafish — PLab aims to identify candidate treatment compounds for each disease, which can then be refined and taken to the clinic with partner companies.

«We didn't know if zebrafish would be a relevant model for opioid addiction, much less self - administer the drug,» Peterson said.

In genetics, the zebrafish is considered an important model organism for studies of vertebrates.

The zebrafish is used as a model organism for research into the embryonic development of vertebrates.

A zebrafish model of Dravet syndrome, a severe form of pediatric epilepsy, may help scientists quickly find drugs for the devastating disease.

«Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial: Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»

Now OIST researchers in the Developmental Neurobiology Unit have exposed a similar syndrome in zebrafish, which are an excellent model for studying human diseases.

This approach opens new avenues for research into memory using zebrafish as model organism,» concludes Dr. Okamoto.

The zebrafish's transparency, small size, and rapid reproduction make it one of the best models for studying how animals and bacteria «talk» to each other, she adds.

Researchers have pursued alternative therapies for TB using a variety of animal models, including the zebrafish found in many pet stores and household aquariums.

Zebrafish (pictured above) are often used as a model for studying vertebrate development.

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

Microinjection of wild - type human ACVR1 RNA into alk8 — / — zebrafish embryos rescued approximately 80 % of the injected embryos completely or partially (Figure 3, C and F), showing that human ACVR1 can function as a BMP type I receptor in this zebrafish model and substitute for Alk8.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

Zebrafish is an ideal model for extending the scope of genomics to vertebrate development.

Non-mammalian animals like zebrafish, fruit flies, nematode worms and even seemingly more exotic creatures like salamanders and Mexican blind cavefish provide powerful experimental models for understanding fundamental biology and disease mechanisms.

With the first spontaneous movements taking place as early as 17 hours post-fertilization and swimming behavior occuring after 27 hours, zebrafish embryos prove to be a good model for the study of development of locomotor activity.

So desirable is the zebrafish as a scientific model that the National Institutes of Health recently launched the NIH Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell azebrafish as a scientific model that the National Institutes of Health recently launched the NIH Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell aZebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell and taste.

The reasons for its appeal are many, but none rival the fact that the crystal - clear zebrafish embryo offers a view of burgeoning life that no other vertebrate model can.

Being social animals, zebrafish are an interesting model for studying psychiatric disorders that affect social behavior, such as schizophrenia and autism.

Toxicology and compound testing The zebrafish model system is ideal for testing biological effects on tissue homeostasis and organism development of substances and pollutants.

In order to test whether isradipine, minocycline, and rasagiline could protect or restore locomotor functioning after treatment with 6 - OHDA (a well - known model for Parkinson's), the zebrafish larvae were tested using DanioVision.

11:50 - 12:10 Per - Erik Olsson, Örebro University, School of Science and Technology Zebrafish as a model for endocrine disruption

Diaphanous zebrafish embryo reveals its «artful etchings» The significance of the UCSF discoveries dramatizes the importance of the tiny blue - and - silver striped denizen of India's Ganges River - and many an aquarium — as a model for biomedical studies.

From axolotls to zebrafish, this story explores some of science's classic models, others more unusual, but all with potential for increasing our understanding of biology to improve human health.

Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections.

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

Zebrafish are one of the most promising models for the study of early vertebrate development and gene function.

Having realized my passion for the same and determined about improvising medical treatment for melanoma cancer I am now working on «Functional in vivo screening of novel oncogenic driver mutations in a zebrafish melanoma model» under the guidance of Prof. Levesque Mitchell Paul.

The zebrafish comes close to being the ideal model organism for vertebrate development because it appears to combine the best features of all the other models.

Dr. Yin had been studying heart regeneration in zebrafish (a common animal model for research) for about ten years.

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

In addition to research on rhabdomyosarcoma, the Ignatius laboratory has also generated new syngeneic zebrafish models of aggressive Malignant Nerve Sheath Tumors and hemangiosarcomas for which there are no effective treatments.

Zebrafish tumor models provide a unique discovery platform for in vivo drug screens, imaging and genetics.

For example, the zebrafish, a common aquarium specimen, possesses the remarkable ability to rapidly replace damaged and lost body parts including limbs, heart, and nervous system, making it an ideal model for defining the genetic mechanisms of regeneration and healing and for identifying drug candidates for use in regenerative mediciFor example, the zebrafish, a common aquarium specimen, possesses the remarkable ability to rapidly replace damaged and lost body parts including limbs, heart, and nervous system, making it an ideal model for defining the genetic mechanisms of regeneration and healing and for identifying drug candidates for use in regenerative medicifor defining the genetic mechanisms of regeneration and healing and for identifying drug candidates for use in regenerative medicifor identifying drug candidates for use in regenerative medicifor use in regenerative medicine.

As with other model organisms, the fully sequenced zebrafish genome has acted as an invaluable reference tool for scientists.