Sentences with phrase «zebrafish models of»

Through studying these genes, the researchers discovered Stasimon, a novel gene critical for motor circuit activity in fly and zebrafish models of SMA.

In addition to research on rhabdomyosarcoma, the Ignatius laboratory has also generated new syngeneic zebrafish models of aggressive Malignant Nerve Sheath Tumors and hemangiosarcomas for which there are no effective treatments.

Developing zebrafish models of complex phenotypes relevant to human brain disorders.

A simple and inexpensive zebrafish model of concussion, reported in eNeuro, reveals the genetic pathways underlying the animal's remarkable ability to regenerate injured brain tissue.

To test whether fatty acid levels in the bloodstream was a cause or a consequence of disease, the researchers turned to a zebrafish model of Crohn's disease that had been developed by Stefan Oehlers, a post-doctoral fellow in David Tobin's group at Duke.

The next steps for the research group are to use what they have learned from this zebrafish model of gut inflammation to design better probiotics to treat intestinal inflammation.

A zebrafish model of Dravet syndrome, a severe form of pediatric epilepsy, may help scientists quickly find drugs for the devastating disease.

Now, a study in the journal Brain describes what could be considered a direct «aquarium - to - bedside» approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease.

A Zebrafish Model of Wet Macular Degeneration Daniel Chao, MD, PhD University of California, San Diego (La Jolla, CA)

In a zebrafish model of cryptococcal disease, a decrease in ERK5 activity led to reduced dissemination of infection by an increase in vomocytosis.

Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.

Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt - deficient hair cells.

Not exact matches

More recently, Godinho Ferreira, who now employs three Ph.D. students and four postdocs, has been working to establish Zebrafish as a new model system to try and understand the role of telomeres in aging and the role of telomere - elongation enzymes in cancer.

Zebrafish that stop swimming when left without company are showing promise as the first fish model of a human mood disorder.

«We knew that the brain hat was a very high potential» among marchers, says Chris Pierret, a biologist at the Mayo Clinic in Rochester, but his group commissioned crocheted zebrafish hats, honoring one of their favorite disease research models.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

She commented: «Our previous research to validate zebrafish as a model for epilepsy put us in a good position to be able to help the EuroEPINOMICS consortium investigate the function of CHD2.

«Zebrafish brain repair following concussion: New model enables study of animal's remarkable ability to regenerate injured brain tissue.»

In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

Zebrafish larvae and fluorescently marked immune cells allow researchers to track immune system activity in a model of retinal degeneration.

«Using models such as zebrafish and neonatal mice that regenerate their hearts naturally, we can begin to identify important molecules that enhance heart repair,» said Ellen Lien, PhD, of The Saban Research Institute of Children's Hospital Los Angeles.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

Zebrafish have emerged as an important vertebrate model for cardiovascular research for a number of reasons, including the ability to regenerate its heart if damaged, and because the transparency of the embryos allows easy observation of internal processes like blood vessel development.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

Monk and her team study zebrafish because they are excellent models of the vertebrate nervous system.

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

His group studies the cellular and genetic control of gastrulation movements in zebrafish, one of the model organisms studied at the institute besides Drosophila, the C. elegans worm, frogs, mice, and newts.

But overall, the resulting toxicity of the wastewater due to its silver content was negligible to zebrafish embryos — a model animal used in toxicity studies.

Bossé explained that the zebrafish model is scalable and could be used to rapidly screen through thousands of compounds.

Using genetic models in a variety of organisms — yeast, nematodes, fruit flies, zebrafish — PLab aims to identify candidate treatment compounds for each disease, which can then be refined and taken to the clinic with partner companies.

In genetics, the zebrafish is considered an important model organism for studies of vertebrates.

The zebrafish is used as a model organism for research into the embryonic development of vertebrates.

Genetic modification in zebrafish models is cheap and easy, so authors point out that future research on these animal models will contribute to understand the molecular relationship that exists between the proteins involved in the physiopathology of megalencephalic leukoencephalopathy.

The zebrafish's transparency, small size, and rapid reproduction make it one of the best models for studying how animals and bacteria «talk» to each other, she adds.

«We use zebrafish to study Alagille syndrome because these vertebrates allow us to use experimental approaches that aren't possible with other disease models,» says Duc Dong, Ph.D., assistant professor in the Human Genetics Program at SBP and senior author of the paper.

Researchers have pursued alternative therapies for TB using a variety of animal models, including the zebrafish found in many pet stores and household aquariums.

Using zebrafish as a model system, the researchers exposed the fish embryos to seven different types of TAML activators.

Tobin, who helped to develop the zebrafish as a model of TB, decided to use the system to study the blood vessels associated with granulomas.

Microinjection of wild - type human ACVR1 RNA into alk8 — / — zebrafish embryos rescued approximately 80 % of the injected embryos completely or partially (Figure 3, C and F), showing that human ACVR1 can function as a BMP type I receptor in this zebrafish model and substitute for Alk8.

In addition, the significant number (> 1000) novel models that came from RNA - Seq that were absent from the zebrafish cDNAs suggests that the deep sequencing offered by RNA - Seq can be used to expand the gene annotation of even well - studied model organisms.

«We can harness the power of zebrafish genetics to create genetic models of human diseases.»

The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.

Because of the usefulness of this information, we set ourselves the goals of constructing a zebrafish gene set based on RNA - Seq alone and then identifying the highest quality models.

He has made fundamental contributions to our understanding of vertebrate developmental biology and microRNA - based gene regulation using the model organism zebrafish.

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

Here, the authors leveraged a zebrafish model system to examine the role of that enhancer during development.

Our Scientific goal is the study of the main physiological functions of fish: growth and reproduction and our main models are rainbow trout, zebrafish, medaka, goldfish.

Zebrafish is an ideal model for extending the scope of genomics to vertebrate development.