Sentences with phrase «zebrafish regenerate»
Zebrafish regenerate new heart tissue after injury.
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He and his colleagues decided to study how zebrafish regenerate tissue, looking for ways to activate this process in humans.
Dr. Yin is seeking to understand how zebrafish regenerate damaged tissue so that therapies can be developed to reawaken our dormant genetic codes for regeneration.
Not exact matches
To gain more insights as to why zebrafish are more successful at regenerating spinal tissue, the researchers analyzed the gene expression of fish spinal tissue following injury, identifying seven genes of interest.
While mammals lack the ability to regenerate nervous system tissue after spinal cord injury, zebrafish can regenerate such tissue.
Yin is using zebrafish to study the regeneration of heart tissue because of the amazing capacity of these common aquarium fish to regenerate the form and function of almost any body part, including heart, bone, skin and blood vessels, regardless of their age.
A simple and inexpensive zebrafish model of concussion, reported in eNeuro, reveals the genetic pathways underlying the animal's remarkable ability to regenerate injured brain tissue.
«But the zebrafish heart robustly regenerates missing or damaged tissue in as little as 30 to 60 days.
«Zebrafish brain repair following concussion: New model enables study of animal's remarkable ability to regenerate injured brain tissue.»
In contrast to humans, zebrafish are able to regenerate their spinal cord, even if it has been completely severed.
The team theorizes that zebrafish produce new heart - muscle cells, or cardiomyocytes, in response to injury, which allows them to regenerate undamaged heart muscle.
Researchers at Johns Hopkins Medicine report evidence that zebrafishes» natural ability to regenerate their eyes» retinal tissue can be accelerated by controlling the fishes» immune systems.
«Using models such as zebrafish and neonatal mice that regenerate their hearts naturally, we can begin to identify important molecules that enhance heart repair,» said Ellen Lien, PhD, of The Saban Research Institute of Children's Hospital Los Angeles.
Adult zebrafish are capable of regenerating their spinal cords after a complete severing injury.
Even the heart of an adult zebrafish can regenerate after injury.
Zebrafish have emerged as an important vertebrate model for cardiovascular research for a number of reasons, including the ability to regenerate its heart if damaged, and because the transparency of the embryos allows easy observation of internal processes like blood vessel development.
This is possible because the zebrafish retina contains cells called Müller glia that harbor a gene that allows them to regenerate.
This is not the case, however, in zebrafish, which have a remarkable ability to regenerate damaged tissue, including neural tissue like the retina.
Sometimes referred to as the stem cells of the zebrafish eye, Müller glia are the cells from which all other types of retinal cells are regenerated in the fish.
It was known that zebrafish is able to regenerate organs, and that electrical currents may play a role in this process, but the exact mechanisms are still unclear.
The study, led by Yadong Wang, the William Kepler Whiteford Professor in Bioengineering in the Swanson School of Engineering and the principal investigator of the Biomaterials Foundry at Pitt, found that a single administration of extracellular matrices (ECM) from zebrafish hearts restored the function of the heart and regenerated adult mouse heart tissues after acute myocardial infarction.
Now, a University of Pittsburgh researcher has used the components of the cellular «scaffolding» of a zebrafish to regenerate heart tissues in mammals, specifically mice, as well as exhibiting promising results in human heart cells in vitro.
They described how the drug candidate, MSI - 1436, regenerates heart muscle tissue in zebrafish and mice in the journal Regenerative Medicine.
Franziska Knopf (Weidinger, TUD)-- «Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin» (2011)
The researchers are using the zebrafish to study how heart tissue regenerates because the fish have what they called an «amazing capacity» to regenerate the form and function of almost any of their body parts.
To learn from zebrafish how to enable the adult brains to better cope with neurodegenerative disease and regenerate
Dr. Voot Yin talks about how research on the common aquarium fish, the zebrafish, may lead to a drug to regenerate healthy heart tissue after a heart attack.
«There are other vertebrates, such as zebrafish, bichir and axolotl, which can regenerate many more different types of tissues, including limbs or appendages.
A new study describes how MSI - 1436, a naturally occurring compound, regenerates heart muscle tissue in zebrafish and mice.
These findings suggest that regenerating organisms such as zebrafish could use special molecular programs to modulate the plasticity of the neural stem cells and enable restoration of compromised neural tissues.
Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins.
«By learning how organisms such as the zebrafish can regenerate damaged tissues and applying these lessons to humans, scientists at MDIBL are increasing our understanding of how we might one day slow and potentially reverse the degenerative effects of aging.
The zebrafish heart robustly regenerates missing or damaged cardiac tissue following a partial ventricular resection procedure in as little as 30 - 60 days.
In randomized experimental and data analysis protocols, MSI - 1346 has been shown to regenerate heart, connective, nerve, skin, bone and vascular tissues in adult zebrafish.
«If you amputate the tail of the zebrafish, it regenerates in about a week, seemingly with no effort and leaving no scar,» explains Stewart.
Without Kdm6b.1, zebrafish failed to regenerate amputated fins, meaning removal of the «off» mark is a prerequisite for fin regeneration.
The scientists found it shares a genetic mechanism with two other creatures that can regenerate tissue — the zebrafish and a ray - finned fish from Africa called the bichir.
In response to Zasloff's hunch that MSI - 1436 might also stimulate regeneration, MDI Biological Laboratory scientist Voot P. Yin, Ph.D., tested the compound for its ability to regenerate heart muscle tissue in zebrafish, and then in mice.
Unlike mammals, the zebrafish is very efficient in regenerating the injured heart.